Effects of HBO on Glucose in Patients With DM
Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
About this trial
This is an interventional treatment trial for Diabetes Mellitus, Type 2 focused on measuring hyperbaric oxygen, continuous glucose monitor, hbo, cgm
Eligibility Criteria
Inclusion Criteria:
- Diagnosis of type 1 or type 2 diabetes
- Willing to have 2 subcutaneous glucose monitors for 10 days
- Willing to be NPO after midnight on the day of the study session
- Willing to come to the hyperbaric facility on successive days (one control session and one hyperbaric treatment), spending approximately 3 hours in the facility on each day of testing
- Willing to undergo multiple fingersticks on the days of testing
- Willing to have a peripheral intravenous catheter placed for blood sampling
- Willing to perform four daily fingerstick blood glucose checks throughout the study period
Exclusion Criteria:
- Contraindication to HBO2 as determined by the study investigator (e.g., pregnancy)
- Previous treatment with HBO2 within 30 days of enrollment
- Current use of CGM is not an exclusion, but participants must use study equipment during the study
- Current use of an insulin pump
- Known allergy to medical-grade adhesives
- Extensive skin changes/disease that preclude wearing the sensor on normal skin (e.g. extensive psoriasis, recent burns or severe sunburn, extensive eczema, extensive scarring, extensive tattoos, dermatitis herpetiformis)
Sites / Locations
- Legacy Emanuel Medical CenterRecruiting
Arms of the Study
Arm 1
Arm 2
No Intervention
Experimental
Control
Hyperbaric Oxygen
The first 2-hour session will be a control where participants will sit quietly (as they would in the hyperbaric chamber) and will not be allowed to consume carbohydrates unless directed to by the hyperbaric department hypoglycemia protocol.
The following day for the HBO2 session, subjects will be fitted for an oxygen hood and given a standard HBO2 treatment. In the chamber the pressure will increase to approximately 2-1/2 times normal atmospheric pressure (2.4 atmospheres absolute [ATA]). Once they reach the treatment pressure, subjects will breathe oxygen by placing the hood over their head and securing it in place. They will breathe oxygen for a 30-minute period, and then take the hood off for 5 minutes for an "air break." They will have a total of three 30-minute oxygen periods and two 5-minute air breaks. A subject will be in the hyperbaric chamber for approximately 2 hours.