Effects of Knee-extensor Exercise Training in Chronic Obstructive Pulmonary Disease (COPD) Patients
Primary Purpose
Chronic Obstructive Pulmonary Disease
Status
Completed
Phase
Not Applicable
Locations
Study Type
Interventional
Intervention
High intensity knee-extensor training
Sponsored by
About this trial
This is an interventional basic science trial for Chronic Obstructive Pulmonary Disease focused on measuring exercise, Knee extensor
Eligibility Criteria
Inclusion Criteria:
- COPD diagnosis with FEV1<70% exp, FEV1%FVC <70 %
- Age> 50 years
Exclusion Criteria:
- Heart failure
- Symptomatic coronary artery disease
- Cancer
- Alcohol and drug abuse
- Severe mental illness
- Lower respiratory illness
- Participation in exercise- or lung rehabilitation program last 3 months
- pregnancy
- oral steroid use
Sites / Locations
Arms of the Study
Arm 1
Arm Type
Experimental
Arm Label
Knee extensor exercise training
Arm Description
High intensity aerobic knee-extensor exercise training
Outcomes
Primary Outcome Measures
Peak power
Secondary Outcome Measures
Mitochondrial respiration, Vmax
Full Information
NCT ID
NCT01079221
First Posted
March 2, 2010
Last Updated
August 1, 2016
Sponsor
Norwegian University of Science and Technology
1. Study Identification
Unique Protocol Identification Number
NCT01079221
Brief Title
Effects of Knee-extensor Exercise Training in Chronic Obstructive Pulmonary Disease (COPD) Patients
Official Title
Effects of Knee-extensor Exercise Training in Chronic Obstructive Pulmonary Disease (COPD) Patients
Study Type
Interventional
2. Study Status
Record Verification Date
August 2016
Overall Recruitment Status
Completed
Study Start Date
February 2009 (undefined)
Primary Completion Date
June 2010 (Actual)
Study Completion Date
December 2012 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Norwegian University of Science and Technology
4. Oversight
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
COPD patients have a reduced exercise tolerance due to a ventilatory limitation.
Several studies have shown altered skeletal muscle function. The investigator will study the physiological response to knee-extensor exercise in COPD patients.
Detailed Description
Reduced exercise tolerance is one of the hallmarks of COPD. The principal causes for exercise intolerance are ventilatory limitation leading to deconditioning and inactivity. However the weak correlation between exercise capacity and FEV1 implies that other factors than reduced pulmonary function contribute to this impairment as well. Several studies have found changes in skeletal muscle, with fibre shift, increased oxidative stress, increased inflammatory cytokines and impaired mitochondrial function, suggesting a lower limb dysfunction.
Numerous exercise studies in COPD patients have shown physiological and physiological benefits of training and endurance training is now regarded as an important part in pulmonary rehabilitation.
In this study we investigate training effects in patients with moderate to severe COPD with special focus on skeletal muscle.
COPD patients will perform high intensity aerobic interval knee-extensor exercise training 3 days/week for six weeks . At baseline and follow-up, muscle oxygen consumption and mitochondrial respiration will be measured.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Chronic Obstructive Pulmonary Disease
Keywords
exercise, Knee extensor
7. Study Design
Primary Purpose
Basic Science
Study Phase
Not Applicable
Interventional Study Model
Single Group Assignment
Masking
None (Open Label)
Allocation
N/A
Enrollment
12 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Knee extensor exercise training
Arm Type
Experimental
Arm Description
High intensity aerobic knee-extensor exercise training
Intervention Type
Behavioral
Intervention Name(s)
High intensity knee-extensor training
Intervention Description
High intensity aerobic knee-extensor exercise training, 4x 3 minutes interval training at < 90 % of peak power, 3 days/week for 6 weeks
Primary Outcome Measure Information:
Title
Peak power
Time Frame
At inclusion and after 6 weeks of training
Secondary Outcome Measure Information:
Title
Mitochondrial respiration, Vmax
Time Frame
At inclusion and after 6 weeks of training
10. Eligibility
Sex
All
Minimum Age & Unit of Time
50 Years
Maximum Age & Unit of Time
80 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
COPD diagnosis with FEV1<70% exp, FEV1%FVC <70 %
Age> 50 years
Exclusion Criteria:
Heart failure
Symptomatic coronary artery disease
Cancer
Alcohol and drug abuse
Severe mental illness
Lower respiratory illness
Participation in exercise- or lung rehabilitation program last 3 months
pregnancy
oral steroid use
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Ulrik Wisløff, PhD prof.
Organizational Affiliation
Norwegian University of Science and Technology
Official's Role
Study Director
12. IPD Sharing Statement
Citations:
PubMed Identifier
22408206
Citation
Bronstad E, Rognmo O, Tjonna AE, Dedichen HH, Kirkeby-Garstad I, Haberg AK, Ingul CB, Wisloff U, Steinshamn S. High-intensity knee extensor training restores skeletal muscle function in COPD patients. Eur Respir J. 2012 Nov;40(5):1130-6. doi: 10.1183/09031936.00193411. Epub 2012 Mar 9.
Results Reference
result
Learn more about this trial
Effects of Knee-extensor Exercise Training in Chronic Obstructive Pulmonary Disease (COPD) Patients
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