Effects of Lung Volume on Upper Airway Patency During Drug Induced Sleep Endoscopy (DISE-Pulm)
Obstructive Sleep Apnea
About this trial
This is an interventional basic science trial for Obstructive Sleep Apnea
Eligibility Criteria
Inclusion Criteria:
- Adult patients (≥ 18 yrs) willing and capable of providing informed consent
- Obstructive sleep apnea (AHI ≥ 5 events/hr)
- Must be willing and able to provide informed consent to participate in the study.
Interested in surgical treatments of OSA and have consented for a DISE procedure as part of their routine clinical evaluation.
- Patients are evaluated and cleared by anesthesia prior to the procedure.
- Coronavirus disease 2019 (COVID-19) vaccinated subjects or subjects with a negative COVID-19 polymerase chain reaction (PCR) test as directed by the pre-procedure clearance policy at the institution.
Exclusion Criteria:
- No significant uncontrolled medical co-morbidities (e.g., uncontrolled hypertension, unstable angina, uncompensated heart failure or COPD).
- Any medical comorbidity that would prevent the patient from receiving anesthesia or having surgery
- Inability to tolerate negative pressure ventilator or perform PFT (i.e. claustrophobia)
- No incapacitating disability that interferes with execution of the protocol
Sites / Locations
- Emory University Hospital MidtownRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Negative Pressure Ventilator
Transcutaneous Phrenic Nerve Stimulation
Participants with obstructive sleep apnea (OSA) who are being evaluated for surgical treatment of their OSA and having a routine clinical DISE will have their lung volume increased with a non-invasive negative pressure ventilator. Participants will also have a pulmonary function test performed per routine clinical protocol, but for research purposes only (i.e., not part of usual care).
Participants with obstructive sleep apnea (OSA) who are being evaluated for surgical treatment of their OSA and having a routine clinical DISE will have their lung volume increased with transcutaneous phrenic nerve stimulation. Participants will also have a pulmonary function test performed per routine clinical protocol, but for research purposes only (i.e., not part of usual care).