Effects of Medium Chain Triglyceride Oil, Versus Olive Oil, for Weight Loss (Muffin)
Primary Purpose
Overweight
Status
Completed
Phase
Not Applicable
Locations
United States
Study Type
Interventional
Intervention
Weight loss
Sponsored by
About this trial
This is an interventional treatment trial for Overweight focused on measuring Overweight, Obesity, Weight loss, Medium chain triglycerides, Cardiovascular disease risk
Eligibility Criteria
Inclusion Criteria:
- body mass index 27-33 kg/m2
- pre-menopausal women
- weight stable for at least 6 months
- normal score on Brief Symptoms Inventory questionnaire
Exclusion Criteria:
- chronic disease
- weight loss treatment
- medication known to affect body weight
- unstable blood pressure, glucose, lipid levels
Sites / Locations
- University of Alabama at Birmingham
Arms of the Study
Arm 1
Arm 2
Arm Type
Active Comparator
Placebo Comparator
Arm Label
1
2
Arm Description
MCT oil consumption
Olive oil consumption
Outcomes
Primary Outcome Measures
Change in body weight and fat mass, change in plasma lipid concentrations, fasting glucose and fasting insulin
Secondary Outcome Measures
Change in blood pressure, change in fat-free mass
Full Information
NCT ID
NCT00529919
First Posted
September 12, 2007
Last Updated
September 12, 2007
Sponsor
University of Alabama at Birmingham
Collaborators
International Life Sciences Institute
1. Study Identification
Unique Protocol Identification Number
NCT00529919
Brief Title
Effects of Medium Chain Triglyceride Oil, Versus Olive Oil, for Weight Loss
Acronym
Muffin
Official Title
The Effects of a Weight Loss Diet Containing Medium Chain Triglyceride Oil, Versus Olive Oil, on Body Composition in Free-Living Adults
Study Type
Interventional
2. Study Status
Record Verification Date
September 2007
Overall Recruitment Status
Completed
Study Start Date
March 2005 (undefined)
Primary Completion Date
undefined (undefined)
Study Completion Date
June 2007 (Actual)
3. Sponsor/Collaborators
Name of the Sponsor
University of Alabama at Birmingham
Collaborators
International Life Sciences Institute
4. Oversight
Data Monitoring Committee
No
5. Study Description
Brief Summary
The primary aim of this research project is to determine whether the incorporation of food products containing medium chain triglyceride (MCT) oil in a weight-loss program results in a different degree of weight-loss and total and regional fat mass loss than the incorporation of extra light olive oil. The secondary goals are to test whether there are differences in in metabolic risk profile changes between the 2 diets. We hypothesize that men and women who consumed MCT oil as part of their weight loss program will lose more weight and body fat than those who consume olive oil in their weight loss diet.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Overweight
Keywords
Overweight, Obesity, Weight loss, Medium chain triglycerides, Cardiovascular disease risk
7. Study Design
Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
ParticipantCare Provider
Allocation
Randomized
Enrollment
53 (Actual)
8. Arms, Groups, and Interventions
Arm Title
1
Arm Type
Active Comparator
Arm Description
MCT oil consumption
Arm Title
2
Arm Type
Placebo Comparator
Arm Description
Olive oil consumption
Intervention Type
Dietary Supplement
Intervention Name(s)
Weight loss
Other Intervention Name(s)
MCT oil, Neobee 1053, Stepan Company
Intervention Description
Weight loss study including consumption of either 22-25 g of medium chain triglyceride oil or olive oil
Primary Outcome Measure Information:
Title
Change in body weight and fat mass, change in plasma lipid concentrations, fasting glucose and fasting insulin
Time Frame
16 weeks
Secondary Outcome Measure Information:
Title
Change in blood pressure, change in fat-free mass
Time Frame
16 weeks
10. Eligibility
Sex
All
Minimum Age & Unit of Time
19 Years
Maximum Age & Unit of Time
50 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
body mass index 27-33 kg/m2
pre-menopausal women
weight stable for at least 6 months
normal score on Brief Symptoms Inventory questionnaire
Exclusion Criteria:
chronic disease
weight loss treatment
medication known to affect body weight
unstable blood pressure, glucose, lipid levels
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Marie-Pierre St-Onge, Ph.D
Organizational Affiliation
St. Luke's-Roosevelt Hospital Center
Official's Role
Principal Investigator
Facility Information:
Facility Name
University of Alabama at Birmingham
City
Birmingham
State/Province
Alabama
ZIP/Postal Code
35294
Country
United States
12. IPD Sharing Statement
Citations:
PubMed Identifier
18845704
Citation
St-Onge MP, Bosarge A, Goree LL, Darnell B. Medium chain triglyceride oil consumption as part of a weight loss diet does not lead to an adverse metabolic profile when compared to olive oil. J Am Coll Nutr. 2008 Oct;27(5):547-52. doi: 10.1080/07315724.2008.10719737.
Results Reference
derived
Learn more about this trial
Effects of Medium Chain Triglyceride Oil, Versus Olive Oil, for Weight Loss
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