Effects of Permissive Hypercapnia on Concentration of Postoperative Plasma Neurofilament Light
Hypercapnia
About this trial
This is an interventional treatment trial for Hypercapnia focused on measuring Neurofilament light, Hypercapnia
Eligibility Criteria
Inclusion Criteria: age over 60 years surgery of greater than 90 min American Society of Anesthesiology (ASA) status Ⅱ-Ⅲ undergoing laparoscopic surgery under general anesthesia with endotracheal intubation Exclusion Criteria: history of mental or neurological disorders preoperative use of antipsychotic drugs American Society of Anesthesiology (ASA) status Ⅳ severe abnormalities in heart, lung, liver, kidney, and coagulation function Intracranial space-occupying lesions or major cerebrovascular diseases (such as carotid atherosclerosis and cerebral aneurysm) Severe hypertension or hypotension Severe metabolic acidosis or hypercapnic respiratory failure before surgery
Sites / Locations
- Affiliated Hospital of Jiaxing UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
permissive hypercapnia
normocapnia
Tidal volume (6-8ml/kg) and respiratory rate is adjusted to achieve the objective values of PaCO2≥46 mmHg
Tidal volume (8-10ml/kg) and respiratory rate is adjusted to achieve the objective values of PaCO2:35~45mmHg