Effects of Noninvasive Brain Stimulation Techniques on BDNF Levels (Plasti-Stim)
Depression, Schizophrenia
About this trial
This is an interventional basic science trial for Depression
Eligibility Criteria
Inclusion Criteria:
- in the depression group: DSM IV criteria of MDD; HDRS17> 22; stage 2 of resistance; received rTMS or ECT
- in the schizophrenia group DSM IV criteria of schizophrenia; pharmaco-resistance of symptoms (either negative symptoms or auditory verbal hallucination); received rTMS or tDCS
- in the healthy volunteers group : to not have axis I of DSM IV diagnosis; no siblings with axis I DSM IV diagnosis
Exclusion Criteria:
- less than 18 years old
- pregnancy
- received benzodiazepine
In the depression and schizophrenia group:
- bipolar disorder
- other axis I of DSM IV diagnosis (excluding for Tobacco use disorder)
Sites / Locations
- Hopital Le vinatierRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Arm 7
Arm 8
Active Comparator
Active Comparator
Sham Comparator
Active Comparator
Sham Comparator
Active Comparator
Sham Comparator
No Intervention
Depression Electroconvulsive therapy
Depression active repetitive transcranial magnetic stimulation
Depression sham repetitive transcranial magnetic stimulation
Schizophrenia active transcranial magnetic stimulati
Schizophrenia sham transcranial magnetic stimulation
Schizophrenia active transcranial Direct Current Stimulation
Schizophrenia sham transcranial Direct Current Stimulation
Healthy volunteers
40 patients with major depression receiving a mean of 12 sessions of Electroconvulsive therapy
40 patients with major depression receiving a mean 4 weeks of 1 Hz repetitive transcranial magnetic stimulation applied over the right dorsolateral prefrontal cortex - DLPFC
40 patients with major depression receiving a mean 4 weeks of sham 1 Hz repetitive transcranial magnetic stimulation applied over the right dorsolateral prefrontal cortex - DLPFC
40 patients with schizophrenia and predominant negative symptoms receiving 20 sessions of intermittent theta burst simulation (iTBS) applied over the left dorsolateral prefrontal cortex - DLPFC
patients with schizophrenia and predominant negative symptoms receiving 20 sessions of sham intermittent theta burst simulation (iTBS) applied over the left dorsolateral prefrontal cortex - DLPFC
40 patients with schizophrenia and auditory verbal hallucinations receiving 10 sessions of transcranial Direct current stimulation (tDCS) applied with the anode over the left dorsolateral prefrontal cortex - DLPFC- and the cathode over the left temporoparietal junction
40 patients with schizophrenia and auditory verbal hallucinations receiving 10 sessions of sham transcranial Direct current stimulation (tDCS) applied with the anode over the left dorsolateral prefrontal cortex - DLPFC- and the cathode over the left temporoparietal junction
80 healthy volunteers receiving no stimulation