Effects of Oxygen Treatment on Mechanisms Involved in Ischemia-reperfusion Injury: A Pilot Study in Healthy Volunteers
Myocardial Infarction, Inflammation, Acute Coronary Syndrome (ACS)
About this trial
This is an interventional treatment trial for Myocardial Infarction focused on measuring Myocardial Infarction, Oxygen, Inflammation, Acute coronary syndrome (ACS), ST-segment elevation myocardial infarction (STEMI), Reperfusion injury (IR-injury), Biomarkers, Normoxemia, Salmonella typhi, Vaccine-induced inflammation, Soluble markers of apoptosis, Leukocyte subset distribution, Matrix metalloproteinase (MMP), Biological Markers
Eligibility Criteria
Inclusion Criteria:
- Age 18-40 years
- Male gender
Exclusion Criteria:
- Female gender
- Not willing to participate
- Not able to communicate or to understand study instructions
- Participation in another on-going trial
- Any chronic disease
- Any acute disease within 30 days of study inclusion
- Any regular or temporary medication within 15 days of study inclusion
- Current smokers
Sites / Locations
- Linköping University Hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Experimental
Experimental
Salmonella typhi vaccine
Salmonella typhi vaccine + oxygen
S. typhi vaccine + oxygen + Atorvastatin
0.5 mL Salmonella typhi vaccine
0.5 mL Salmonella typhi vaccine + 6l/min oxygen
0.5 mL Salmonella typhi vaccine + 6l/min oxygen + 80mg Atorvastatin