Effects of Remote Ischemic Pre-Conditioning in Moyamoya Disease Patients (RIME)
Moyamoya Disease, Remote Ischemic Preconditioning
About this trial
This is an interventional treatment trial for Moyamoya Disease focused on measuring Moyamoya Disease, Cerebrovascular Disorders, Arterial Occlusive Diseases, Ischemia
Eligibility Criteria
Inclusion Criteria:
- Patients who diagnosed with moyamoya disease
- Adults 18 to 65 years of age
- The onset symptoms manifested as ischemic symptoms (TIA or stroke) or atypical symptoms (headache, epilepsy or asymptomatic)
- Able to receive the necessary imaging examination
- Patients who pre-agreed to the study
Exclusion Criteria:
- Prior cerebral hemorrhage history
- Other brain or cerebrovascular disease
- Previous history of revascularization surgery
- Dependent (mRS > 2)
- Receive other type of revascularization surgery
- Peripheral blood vessel disease (especially subclavian arterial and upper limb artery stenosis or occlusion).
- Patients who do not agree with the study
Sites / Locations
- Beijing Tiantan Hosiptal
- Peking University International Hospital
Arms of the Study
Arm 1
Arm 2
Sham Comparator
Experimental
Sham RIPC group
RIPC group
Treatment:Patients in this group received standard medical therapy and sham remote ischemic preconditioning treatment. Device:Sham RIPC consisted of five 5-min cycles of bilateral arm ischemia/reperfusion, which is induced by a sphygmomanometer placed on bilateral arm and inflated to 60 mmHg for 5-min followed by deflating the cuff for 5-min, each patient in Sham RIPC group do it twice a day for at least five days before encephaloduroarteriosynangiosis. Procedure: Encephaloduroarteriosynangiosis
Treatment:Patients in this group received standard medical therapy and remote ischemic preconditioning (RIPC) treatment. Device:RIPC consisted of five 5-min cycles of bilateral arm ischemia/reperfusion, which is induced by a sphygmomanometer placed on bilateral arm and inflated to 200 mmHg for 5-min followed by deflating the cuff for 5-min,each patient in the RIPC group do it twice a day for at least five days before encephaloduroarteriosynangiosis. Procedure: Encephaloduroarteriosynangiosis