Effects of Remote Ischemic PreConditioning in Off-pump Versus On-pump Coronary Artery Bypass Grafting(RIPCON) (RIPCON)
Myocardial Injury

About this trial
This is an interventional treatment trial for Myocardial Injury focused on measuring remote ischemic preconditioning, coronary artery bypass grafting, myocardial injury
Eligibility Criteria
Inclusion Criteria:
- Confirmed triple vessel coronary artery disease
- Indication for surgical coronary revascularisation
- Written informed consent
- Age ≥ 18 years
Exclusion Criteria:
- Age > 80 years
- Instable angina/acute coronary syndrome
- Emergency surgery
- Recent myocardial infarction within 7 days prior to surgery
- Recent major infection/sepsis within 7 days prior to surgery
- Significant hepatic, renal oder pulmonary disease
- Other concomitant surgical procedures
Sites / Locations
- Dept. Cardiovascular Surgery, University Hospital, Heinrich Heine UniversityRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Active Comparator
Placebo Comparator
Active Comparator
Placebo Comparator
RIPC-CABG
Control-CABG
RIPC-OPCAB
Control-OPCAB
Remote ischemic preconditioning (RIPC) protocol before coronary artery bypass surgery with blood cardioplegia for cardiac arrest (CABG) consists of 3 cycles of 5 minutes left upper arm ischemia by inflation of a blood pressure cuff to 200 mmHg and 5 minutes of reperfusion after induction of anesthesia before coronary artery bypass surgery. For myocardial molecular analyses, left ventricular biopsies are taken before induction of cardioplegic cardiac arrest and 5 to 10 Minutes after aortic unclamping during reperfusion of the myocardium. Blood samples are taken up to 72 hours postoperatively.
Control group: Coronary artery bypass grafting without RIPC protocol
Remote ischemic preconditioning (RIPC) protocol before Off-pump coronary artery bypass surgery (OPCAB) consists of 3 cycles of 5 minutes left upper arm ischemia by inflation of a blood pressure cuff to 200 mmHg and 5 minutes of reperfusion after induction of anesthesia before coronary artery bypass surgery. For myocardial molecular analyses, left ventricular biopsies are taken before first coronary artery incision and 5 to 10 Minutes after completion of the coronary anastomoses. Blood samples are taken up to 72 hours postoperatively.
Control group: Off-pump Coronary artery bypass surgery without RIPC protocol