Effects of Sildenafil on Penile Vascular Function in Hypertensive Men With Erectile Dysfunction
Arterial Hypertension, Erectile Dysfunction
About this trial
This is an interventional treatment trial for Arterial Hypertension focused on measuring hypertension, endothelial dysfunction, erectile dysfunction, sildenafil
Eligibility Criteria
Inclusion Criteria:
- arterial hypertension stage I or II
- erectile dysfunction (vasculogenic)
Exclusion Criteria:
- diabetes
- kidney, liver, neurologic and psychiatric diseases
Sites / Locations
- National Institute of Cardiology, Ministry of Health, Brazil
Arms of the Study
Arm 1
Arm 2
Experimental
Sham Comparator
hypertensive patients
comparator group
Hypertensive patients will receive a single oral dose of sildenafil citrate (100 mg) - acute protocol - and a chronic 30-day treatment with sildenafil citrate (50 mg twice daily) - chronic protocol. Penile and systemic microvascular function will be evaluated before and one hour after acute sildenafil administration and in the end of each treatment period.
Normotensive individuals age-matched to the hypertensive patients will receive only a single dose of sildenafil citrate (100 mg) - acute protocol. Penile and systemic microvascular function will be evaluated before and one hour after sildenafil administration.