Effects of Sublingual Immunotherapy on Grasspollen Allergy

Inclusion Criteria: Age 18 and older. Patients known in general practice with documented clinical history of grass pollen allergy with moderate disease intensity as retrospectively derived from the use of symptomatic allergy medication during the previous grass pollen season, i.e. regular use of cromoglycates as nasal spray and/or eye drops, and/or regular use of anti histamine tablets or sprays and/or limited use of local acting or systemically administered corticosteroids. Positive (ARTU) grass pollen specific skin prick test (despite negative RAST). Exclusion Criteria: Clinical history of severe asthmatic symptoms requiring inhalant therapy with daily pulmonary steroids during at least 3 months a year. Symptomatic perennial allergic rhinitis. Meaning perennial allergy is allowed if the allergen is not present in patients' daily life (especially one month prior to provocation) and if they have no apparent symptoms of this perennial allergy. Other seasonal allergic rhinitis are not allowed unless it is asymptomatic during the period of provocation. The intention to subject the patient to surgery of the nasal cavity in the course of the study. Previous immunotherapy. Negative (ARTU) grass pollen specific skin prick test (despite positive RAST). Contraindications to sublingual immunotherapy, i.e.: Malignancies and serious disorders of the oral cavity History of status asthmaticus and anaphylactic shock Aggressively developing asthmatic symptoms Serious chronic inflammations, chronic disorders associated with fever, particularly of the bronchial tubes Irreversible, secondary changes in reactive organs (emphysema, bronchiectasis) Auto immune diseases and immunodeficiency Concurrent therapy involving immunosuppressives Systemic and collagen diseases Tuberculosis of the lung and tuberculosis Serious psychological disorders Documented hypersensitivity to glycerol Pregnancy Serious cardiovascular disease Usage of b -blockers