Effects of Transcranial Magnetic Stimulation (TMS) and Stimulus Controllability on Pain Perception
Chronic Pain
About this trial
This is an interventional other trial for Chronic Pain focused on measuring Pain
Eligibility Criteria
Inclusion Criteria:
- 18-75 years of age
Exclusion Criteria:
- history of seizures or epilepsy
- family history of seizures
- history of chronic pain conditions
- current depression
- anxiety disorders
- taking any medications shown to lower seizure threshold
- metal implants above the waist
- pregnant
- brain tumors or lesions
- pacemaker
Sites / Locations
- Brain Stimulation Laboratory, Institute of Psychiatry
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Sham Comparator
Other
Real TMS
Sham TMS
All Participants Operator Role
Participants in the real Transcranial Magnetic Stimulation (TMS) group will receive real stimulation across all interventions; the operator role Real TMS and receiver role Real TMS. rTMS will be used to stimulate the left prefrontal cortex using two Neuronetics TMS machines with figure-8, iron core coils at 10Hz and at 110% of resting motor threshold [5 second trains following each trial (25 trials per visit)].
Participants in the sham Transcranial Magnetic Stimulation (TMS) group will receive sham stimulation across all interventions; the operator role Sham TMS and receiver role Sham TMS. Sham Stimulation involves 5 second trains of 10Hz rTMS in pairs alternating between real TMS and eSham TMS (randomly ordered). All sham treatment will be delivered with a specially designed, manufacture-provided sham TMS coil that looks and sounds identical to a real TMS coil but no magnetic current is transferred to the participant.
All participants in Operator Role (Receiving real or sham TMS)