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Efficacy and Safety of Benralizumab in Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) With a History of Frequent Exacerbations (RESOLUTE)

Primary Purpose

Chronic Obstructive Pulmonary Disease

Status

Recruiting

Phase

Phase 3

Locations

International

Study Type

Interventional

Intervention

Benralizumab

Placebo

About this trial

This is an interventional treatment trial for Chronic Obstructive Pulmonary Disease focused on measuring Chronic Obstructive Pulmonary Disease, COPD, benralizumab, Fasenra, ICS, inhaled corticosteroids, exacerbations, Lung Disease, LABA/LAMA

Eligibility Criteria

40 Years - 85 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

Provision of informed consent
Age 40 to 85 years
Male and/or female.
Current or former smoker with a tobacco history of ≥10 pack-years.
History of moderate to very severe COPD with a post-bronchodilator FEV1/FVC<0.70 and FEV1 ≤65% of predicted normal value.
Documented history of 2 or more COPD exacerbations that required treatment with systemic corticosteroids and/or hospitalization within 52 weeks prior to enrollment.
1. Exacerbations treated with antibiotics alone are excluded unless accompanied by treatment with systemic corticosteroids and/or hospitalization.
2. Hospitalization is defined as an inpatient admission ≥24 hours
3. Previous exacerbations should be confirmed to have occurred while on stable triple therapy for COPD.
4. At least one qualifying COPD exacerbation should occur while on stable uninterrupted triple therapy prior to enrolment.
Documented use of triple (ICS/LABA/LAMA) background therapy for COPD for ≥3 months immediately prior to enrollment.
1. Treatment with at least double inhaled therapy containing ICS (e.g. ICS/LABA or ICS/LAMA) for the remaining of 52 weeks prior to enrolment. Use of LABA/LAMA is allowed if ICS cannot be tolerated.
2. ICS in a dose approved for COPD or equivalent to ≥250 mcg of fluticasone propionate daily.
3. Total cumulative duration of not being on double or triple background therapy must not exceed 2 months.
4. Stable therapy/doses for the last 3 months prior to randomization.
Blood eosinophil count ≥300/μL at screening and documented historical eosinophil count of ≥150/μL within 52 weeks of enrollment (or repeated testing during run-in).
CAT total score ≥15 at Visit 1.
Negative pregnancy test for females of childbearing potential (WOCBP) at Visit 1.
Women of childbearing potential (WOCBP) must agree to use a highly effective method of birth control from enrollment throughout the study and within 12 weeks after last dose of IP.

Women not of childbearing potential are defined as women who are either permanently sterilized or postmenopausal (confirmed by FSH test for women <50 years).

Exclusion Criteria:

Clinically important pulmonary disease other than COPD
Current diagnosis of asthma, prior history of asthma or asthma-COPD overlap according to GINA/GOLD. Childhood history of asthma is allowed and defined as asthma diagnosed and resolved before the age of 18.
Radiological findings of a respiratory disease other than COPD contributing to respiratory symptoms. Solitary pulmonary nodules without appropriate follow up or findings of acute infection.
Another pulmonary or systemic disease associated with elevated peripheral eosinophil counts.
Any unstable disorder that could affect patient safety, study findings or the patient's ability to complete the study.
Any clinically significant abnormal findings in physical examination, vital signs, ECG, laboratory tests could affect patient safety, study findings or the patient's ability to complete the study.
Cor pulmonale and/or right ventricular failure.
Long-term treatment with oxygen >4.0 L/min and/or oxyhemoglobin saturation <89% while breathing supplemental oxygen.
Use of any non-invasive positive pressure ventilation device (NIPPV). Note: use of CPAP for Sleep Apnea Syndrome is allowed.
Known immunodeficiency disorder, including positive HIV-1/2 testing.
Active liver disease. Chronic stable hepatitis B and C (including positive HBsAg or hepatitis C antibody testing), or other stable chronic liver disease are acceptable.
ALT or AST ≥3 times the upper limit of normal, confirmed by repeated testing during the run-in period.
Helminth parasitic infection within 24 weeks prior to enrollment, not treated or failed to respond to standard of care therapy.
Alcohol or drug abuse within the past year, which may compromise the study data.
Malignancy, current or within the past 5 years, except for adequately treated non invasive basal cell and squamous cell carcinoma of the skin and cervical carcinoma-in-situ treated with apparent success more than 1 year prior to Visit 1. Suspected malignancy or undefined neoplasms.
Evidence of active tuberculosis, as judged by investigator. Patients with a recent (within 2 years) first-time or newly positive PPD or Quantiferon test need to complete an appropriate course of treatment before enrollment. Evaluation will be according to the local standard of care.
Participation, or planned participation, in intensive COPD rehabilitation program (maintenance phase of a rehabilitation is allowed).
History of surgical or endoscopic lung volume reduction within the 6 months prior to enrollment. History of partial or total lung resection (single lobe or segmentectomy is acceptable).
Scheduled major surgical procedure during the study. Minor elective procedures are allowed.
History of anaphylaxis to any biologic therapy or vaccine.
Receipt of blood products or immunoglobulins within 30 days prior to randomization.
Receipt of marketed or investigational biologic product within 4 months or 5 half-lives prior to randomization, whichever is longer. Exception: Patients on stable therapy for 3 months before randomization who intend to stay on treatment throughout the study with marketed biologic products that are not likely to interfere with the safety assessment and/or efficacy of benralizumab, for example, for the treatment of osteoporosis, migraine, pain, diabetes, obesity, ocular, cardiovascular, or metabolic diseases, can participate in the study.
Receipt of live attenuated vaccines 30 days prior to randomization.
Chronic use of immunosuppressive medication or expected need for chronic use during the study.
Chronic use of antibiotics if duration of treatment is <9 months prior to randomization. Chronic macrolide or other antibiotic therapy is allowed provided the patient has been on stable dose/regimen for ≥9 months prior to randomization and has had ≥2 COPD exacerbations while on stable therapy.
Receipt of any investigational non-biologic product within 30 days or 5 half-lives prior to enrollment.
Receipt of benralizumab within 12 months prior to enrollment.
Known history of allergy or reaction to any component of the IP formulation.

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Placebo Comparator

Arm Label

Benralizumab

Placebo

Arm Description

Administrated subcutaneously (SC) every 4 weeks for the first 3 doses, then every 8 weeks

Administrated subcutaneously every 4 weeks for the first 3 doses, then every 8 weeks

Outcomes

Primary Outcome Measures

Annualized rate of moderate or severe COPD exacerbations

Moderate or severe COPD exacerbation is defined by symptomatic worsening of COPD requiring: Use of systemic corticosteroids for at least 3 days; and/or Use of antibiotics; and/or An inpatient hospitalization or death due to COPD

Secondary Outcome Measures

Annualized rate of severe COPD exacerbations

A severe COPD exacerbation is defined by symptomatic worsening of COPD requiring an inpatient hospitalization or results in death due to COPD

Annualized rate of COPD exacerbations that are associated with an emergency room/emergency department visit or a hospitalization

Time to first COPD exacerbation

Change from baseline in SGRQ total and domain scores

St. George's Respiratory Questionnaire (SGRQ)

Change from baseline in E-RS:COPD total and domain scores

Evaluating Respiratory Symptoms in COPD (E-RS:COPD)

Change from baseline in pre-dose/pre-bronchodilator FEV1

FEV1 is the Forced expiratory volume in one second at study site

All cause and respiratory-related mortality rate

Annual rate of hospitalizations due to COPD

Serum benralizumab concentration as a measure of pharmacokinetics

Anti-drug antibodies (ADA) as a measure of immunogenicity

Change from baseline in CAT total score

Chronic Obstructive Pulmonary Disease assessment tool (CAT)

Length of hospital stay

ICU (Intensive Care Unit) days

Annual rate of hospitalizations and emergency department visits combined

Annual rate of unscheduled outpatient visits including unscheduled visits to study sites

Annual rate of unscheduled healthcare encounters

Full Information

NCT ID

NCT04053634

First Posted

July 16, 2019

Last Updated

October 17, 2023

Sponsor

AstraZeneca

1. Study Identification

Unique Protocol Identification Number

NCT04053634

Brief Title

Efficacy and Safety of Benralizumab in Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) With a History of Frequent Exacerbations

Acronym

RESOLUTE

Official Title

A Multicenter, Randomized, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Phase 3 Study to Evaluate the Efficacy and Safety of Benralizumab 100 mg in Patients With Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) With a History of Frequent COPD Exacerbations and Elevated Peripheral Blood Eosinophils (RESOLUTE)

Study Type

Interventional

2. Study Status

Record Verification Date

October 2023

Overall Recruitment Status

Recruiting

Study Start Date

August 26, 2019 (Actual)

Primary Completion Date

June 27, 2025 (Anticipated)

Study Completion Date

June 27, 2025 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

AstraZeneca

4. Oversight

Studies a U.S. FDA-regulated Drug Product

Yes

Studies a U.S. FDA-regulated Device Product

5. Study Description

Brief Summary

Phase 3 study to evaluate the efficacy and safety of a benralizumab in patients with moderate to very severe COPD with a history of frequent COPD exacerbations and elevated peripheral blood eosinophils (≥300/μL). Eligible patients must have a history of ≥2 moderate and/or severe COPD exacerbations in the previous year despite receiving triple (ICS/LABA/LAMA) background therapy for at least 3 months and ICS-based dual inhaled treatment for the remainder of the year. Eligible patients must also have an elevated blood eosinophil count. The treatment period will be of variable duration and will continue until the last patient has the opportunity to complete a minimum of 56 weeks, at which point all patients will complete the study. The primary endpoint will be analyzed at Week 56.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Chronic Obstructive Pulmonary Disease

Keywords

Chronic Obstructive Pulmonary Disease, COPD, benralizumab, Fasenra, ICS, inhaled corticosteroids, exacerbations, Lung Disease, LABA/LAMA

7. Study Design

Primary Purpose

Treatment

Study Phase

Phase 3

Interventional Study Model

Parallel Assignment

Masking

ParticipantCare ProviderInvestigator

Allocation

Randomized

Enrollment

642 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title

Benralizumab

Arm Type

Experimental

Arm Description

Administrated subcutaneously (SC) every 4 weeks for the first 3 doses, then every 8 weeks

Arm Title

Placebo

Arm Type

Placebo Comparator

Arm Description

Administrated subcutaneously every 4 weeks for the first 3 doses, then every 8 weeks

Intervention Type

Biological

Intervention Name(s)

Benralizumab

Intervention Description

Benralizumab solution for injection in accessorized prefilled syringe (APFS) will be administered subcutaneously (SC) every 4 weeks for the first 3 doses - Weeks 0, 4 and 8, and then every 8 weeks until the end of treatment.

Intervention Type

Biological

Intervention Name(s)

Placebo

Intervention Description

Matching placebo will be administered subcutaneously with accessorized prefilled syringe (APFS) every 4 weeks for the first 3 doses - Weeks 0, 4 and 8, and then every 8 weeks until the end of treatment.

Primary Outcome Measure Information:

Title

Annualized rate of moderate or severe COPD exacerbations

Description

Time Frame

Over first 56 weeks

Secondary Outcome Measure Information:

Title

Annualized rate of severe COPD exacerbations

Description

A severe COPD exacerbation is defined by symptomatic worsening of COPD requiring an inpatient hospitalization or results in death due to COPD

Time Frame

Minimum of 1 year and an average of 2 years

Title

Annualized rate of COPD exacerbations that are associated with an emergency room/emergency department visit or a hospitalization

Time Frame

Minimum of 1 year and an average of 2 years

Title

Time to first COPD exacerbation

Time Frame

During first 56 weeks

Title

Change from baseline in SGRQ total and domain scores

Description

St. George's Respiratory Questionnaire (SGRQ)

Time Frame

up to 56 weeks

Title

Change from baseline in E-RS:COPD total and domain scores

Description

Evaluating Respiratory Symptoms in COPD (E-RS:COPD)

Time Frame

up to 56 weeks

Title

Change from baseline in pre-dose/pre-bronchodilator FEV1

Description

FEV1 is the Forced expiratory volume in one second at study site

Time Frame

up to 56 weeks

Title

All cause and respiratory-related mortality rate

Time Frame

Minimum of 1 year and an average of 2 years

Title

Annual rate of hospitalizations due to COPD

Time Frame

Minimum of 1 year and an average of 2 years

Title

Serum benralizumab concentration as a measure of pharmacokinetics

Time Frame

up to 56 weeks

Title

Anti-drug antibodies (ADA) as a measure of immunogenicity

Time Frame

up to 56 weeks

Title

Change from baseline in CAT total score

Description

Chronic Obstructive Pulmonary Disease assessment tool (CAT)

Time Frame

up to 56 weeks

Title

Length of hospital stay

Time Frame

Minimum of 1 year and an average of 2 years

Title

ICU (Intensive Care Unit) days

Time Frame

Minimum of 1 year and an average of 2 years

Title

Annual rate of hospitalizations and emergency department visits combined

Time Frame

Minimum of 1 year and an average of 2 years

Title

Annual rate of unscheduled outpatient visits including unscheduled visits to study sites

Time Frame

Minimum of 1 year and an average of 2 years

Title

Annual rate of unscheduled healthcare encounters

Time Frame

Minimum of 1 year and and average of 2 years

Other Pre-specified Outcome Measures:

Title

Safety and tolerability of benralizumab in patients with moderate to very severe COPD

Description

AEs, vital signs, clinical laboratory, and ECG

Time Frame

Minimum of 1 year and average of 2 years

10. Eligibility

Sex

All

Minimum Age & Unit of Time

40 Years

Maximum Age & Unit of Time

85 Years

Accepts Healthy Volunteers

Eligibility Criteria

Inclusion Criteria: Provision of informed consent Age 40 to 85 years Male and/or female. Current or former smoker with a tobacco history of ≥10 pack-years. History of moderate to very severe COPD with a post-bronchodilator FEV1/FVC<0.70 and FEV1 ≤65% of predicted normal value. Documented history of 2 or more COPD exacerbations that required treatment with systemic corticosteroids and/or hospitalization within 52 weeks prior to enrollment. Exacerbations treated with antibiotics alone are excluded unless accompanied by treatment with systemic corticosteroids and/or hospitalization. Hospitalization is defined as an inpatient admission ≥24 hours Previous exacerbations should be confirmed to have occurred while on stable triple therapy for COPD. At least one qualifying COPD exacerbation should occur while on stable uninterrupted triple therapy prior to enrolment. Documented use of triple (ICS/LABA/LAMA) background therapy for COPD for ≥3 months immediately prior to enrollment. Treatment with at least double inhaled therapy containing ICS (e.g. ICS/LABA or ICS/LAMA) for the remaining of 52 weeks prior to enrolment. Use of LABA/LAMA is allowed if ICS cannot be tolerated. ICS in a dose approved for COPD or equivalent to ≥250 mcg of fluticasone propionate daily. Total cumulative duration of not being on double or triple background therapy must not exceed 2 months. Stable therapy/doses for the last 3 months prior to randomization. Blood eosinophil count ≥300/μL at screening and documented historical eosinophil count of ≥150/μL within 52 weeks of enrollment (or repeated testing during run-in). CAT total score ≥15 at Visit 1. Negative pregnancy test for females of childbearing potential (WOCBP) at Visit 1. Women of childbearing potential (WOCBP) must agree to use a highly effective method of birth control from enrollment throughout the study and within 12 weeks after last dose of IP. Women not of childbearing potential are defined as women who are either permanently sterilized or postmenopausal (confirmed by FSH test for women <50 years). Exclusion Criteria: Clinically important pulmonary disease other than COPD Current diagnosis of asthma, prior history of asthma or asthma-COPD overlap according to GINA/GOLD. Childhood history of asthma is allowed and defined as asthma diagnosed and resolved before the age of 18. Radiological findings of a respiratory disease other than COPD contributing to respiratory symptoms. Solitary pulmonary nodules without appropriate follow up or findings of acute infection. Another pulmonary or systemic disease associated with elevated peripheral eosinophil counts. Any unstable disorder that could affect patient safety, study findings or the patient's ability to complete the study. Any clinically significant abnormal findings in physical examination, vital signs, ECG, laboratory tests could affect patient safety, study findings or the patient's ability to complete the study. Cor pulmonale and/or right ventricular failure. Long-term treatment with oxygen >4.0 L/min and/or oxyhemoglobin saturation <89% while breathing supplemental oxygen. Use of any non-invasive positive pressure ventilation device (NIPPV). Note: use of CPAP for Sleep Apnea Syndrome is allowed. Known immunodeficiency disorder, including positive HIV-1/2 testing. Active liver disease. Chronic stable hepatitis B and C (including positive HBsAg or hepatitis C antibody testing), or other stable chronic liver disease are acceptable. ALT or AST ≥3 times the upper limit of normal, confirmed by repeated testing during the run-in period. Helminth parasitic infection within 24 weeks prior to enrollment, not treated or failed to respond to standard of care therapy. Alcohol or drug abuse within the past year, which may compromise the study data. Malignancy, current or within the past 5 years, except for adequately treated non invasive basal cell and squamous cell carcinoma of the skin and cervical carcinoma-in-situ treated with apparent success more than 1 year prior to Visit 1. Suspected malignancy or undefined neoplasms. Evidence of active tuberculosis, as judged by investigator. Patients with a recent (within 2 years) first-time or newly positive PPD or Quantiferon test need to complete an appropriate course of treatment before enrollment. Evaluation will be according to the local standard of care. Participation, or planned participation, in intensive COPD rehabilitation program (maintenance phase of a rehabilitation is allowed). History of surgical or endoscopic lung volume reduction within the 6 months prior to enrollment. History of partial or total lung resection (single lobe or segmentectomy is acceptable). Scheduled major surgical procedure during the study. Minor elective procedures are allowed. History of anaphylaxis to any biologic therapy or vaccine. Receipt of blood products or immunoglobulins within 30 days prior to randomization. Receipt of marketed or investigational biologic product within 4 months or 5 half-lives prior to randomization, whichever is longer. Exception: Patients on stable therapy for 3 months before randomization who intend to stay on treatment throughout the study with marketed biologic products that are not likely to interfere with the safety assessment and/or efficacy of benralizumab, for example, for the treatment of osteoporosis, migraine, pain, diabetes, obesity, ocular, cardiovascular, or metabolic diseases, can participate in the study. Receipt of live attenuated vaccines 30 days prior to randomization. Chronic use of immunosuppressive medication or expected need for chronic use during the study. Chronic use of antibiotics if duration of treatment is <9 months prior to randomization. Chronic macrolide or other antibiotic therapy is allowed provided the patient has been on stable dose/regimen for ≥9 months prior to randomization and has had ≥2 COPD exacerbations while on stable therapy. Receipt of any investigational non-biologic product within 30 days or 5 half-lives prior to enrollment. Receipt of benralizumab within 12 months prior to enrollment. Known history of allergy or reaction to any component of the IP formulation.

Central Contact Person:

First Name & Middle Initial & Last Name or Official Title & Degree

AstraZeneca Clinical Study Information Center

Phone

1-877-240-9479

information.center@astrazeneca.com

Overall Study Officials:

First Name & Middle Initial & Last Name & Degree

Gerard Criner, MD

Organizational Affiliation

Temple University School of Medicine, 3401 North Broad Street, Suite 745 PP, Philadelphia, PA 19140

Official's Role

Principal Investigator

Facility Information:

Facility Name

Research Site

City

Montgomery

State/Province

Alabama

ZIP/Postal Code

36116

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Surprise

State/Province

Arizona

ZIP/Postal Code

85374

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Tucson

State/Province

Arizona

ZIP/Postal Code

85723

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Tucson

State/Province

Arizona

ZIP/Postal Code

85724

Country

United States

Individual Site Status

Suspended

Facility Name

Research Site

City

Little Rock

State/Province

Arkansas

ZIP/Postal Code

72209

Country

United States

Individual Site Status

Completed

Facility Name

Research Site

City

Huntington Beach

State/Province

California

ZIP/Postal Code

92647

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Long Beach

State/Province

California

ZIP/Postal Code

90806

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Los Angeles

State/Province

California

ZIP/Postal Code

90033

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Los Angeles

State/Province

California

ZIP/Postal Code

90048

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Newport Beach

State/Province

California

ZIP/Postal Code

92663

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Northridge

State/Province

California

ZIP/Postal Code

91324

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Palm Springs

State/Province

California

ZIP/Postal Code

92262

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Palm Springs

State/Province

California

ZIP/Postal Code

92262

Country

United States

Individual Site Status

Completed

Facility Name

Research Site

City

San Diego

State/Province

California

ZIP/Postal Code

92103

Country

United States

Individual Site Status

Suspended

Facility Name

Research Site

City

San Diego

State/Province

California

ZIP/Postal Code

92120

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Westminster

State/Province

California

ZIP/Postal Code

92683

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Stamford

State/Province

Connecticut

ZIP/Postal Code

06902

Country

United States

Individual Site Status

Completed

Facility Name

Research Site

City

Newark

State/Province

Delaware

ZIP/Postal Code

19713

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Brandon

State/Province

Florida

ZIP/Postal Code

33511

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Clearwater

State/Province

Florida

ZIP/Postal Code

33765

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Daytona Beach

State/Province

Florida

ZIP/Postal Code

32117

Country

United States

Individual Site Status

Terminated

Facility Name

Research Site

City

Edgewater

State/Province

Florida

ZIP/Postal Code

32132

Country

United States

Individual Site Status

Terminated

Facility Name

Research Site

City

Jacksonville

State/Province

Florida

ZIP/Postal Code

32204

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Jacksonville

State/Province

Florida

ZIP/Postal Code

32209

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kissimmee

State/Province

Florida

ZIP/Postal Code

34741

Country

United States

Individual Site Status

Terminated

Facility Name

Research Site

City

Kissimmee

State/Province

Florida

ZIP/Postal Code

34746

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Leesburg

State/Province

Florida

ZIP/Postal Code

34748

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Miami

State/Province

Florida

ZIP/Postal Code

33125

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Orlando

State/Province

Florida

ZIP/Postal Code

32819

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Pensacola

State/Province

Florida

ZIP/Postal Code

32503

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Saint Petersburg

State/Province

Florida

ZIP/Postal Code

33707

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Tampa

State/Province

Florida

ZIP/Postal Code

33607

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Winter Park

State/Province

Florida

ZIP/Postal Code

32789

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Columbus

State/Province

Georgia

ZIP/Postal Code

31904

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Decatur

State/Province

Georgia

ZIP/Postal Code

30033

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Lawrenceville

State/Province

Georgia

ZIP/Postal Code

30046

Country

United States

Individual Site Status

Completed

Facility Name

Research Site

City

Rincon

State/Province

Georgia

ZIP/Postal Code

31326

Country

United States

Individual Site Status

Completed

Facility Name

Research Site

City

Woodstock

State/Province

Georgia

ZIP/Postal Code

30189

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Chicago

State/Province

Illinois

ZIP/Postal Code

60611

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Evanston

State/Province

Illinois

ZIP/Postal Code

60201

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

O'Fallon

State/Province

Illinois

ZIP/Postal Code

62269

Country

United States

Individual Site Status

Terminated

Facility Name

Research Site

City

Peoria

State/Province

Illinois

ZIP/Postal Code

61636

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Michigan City

State/Province

Indiana

ZIP/Postal Code

46360

Country

United States

Individual Site Status

Completed

Facility Name

Research Site

City

Valparaiso

State/Province

Indiana

ZIP/Postal Code

46383

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Council Bluffs

State/Province

Iowa

ZIP/Postal Code

51503

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Iowa City

State/Province

Iowa

ZIP/Postal Code

52242

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kansas City

State/Province

Kansas

ZIP/Postal Code

66160

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Georgetown

State/Province

Kentucky

ZIP/Postal Code

40324

Country

United States

Individual Site Status

Completed

Facility Name

Research Site

City

Lexington

State/Province

Kentucky

ZIP/Postal Code

40502

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Baltimore

State/Province

Maryland

ZIP/Postal Code

21224

Country

United States

Individual Site Status

Terminated

Facility Name

Research Site

City

Columbia

State/Province

Maryland

ZIP/Postal Code

21044

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Boston

State/Province

Massachusetts

ZIP/Postal Code

02215

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

North Dartmouth

State/Province

Massachusetts

ZIP/Postal Code

02747

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Farmington Hills

State/Province

Michigan

ZIP/Postal Code

48336

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Chesterfield

State/Province

Missouri

ZIP/Postal Code

63017

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Lincoln

State/Province

Nebraska

ZIP/Postal Code

68510

Country

United States

Individual Site Status

Terminated

Facility Name

Research Site

City

Omaha

State/Province

Nebraska

ZIP/Postal Code

68124

Country

United States

Individual Site Status

Terminated

Facility Name

Research Site

City

Brick

State/Province

New Jersey

ZIP/Postal Code

08724

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Toms River

State/Province

New Jersey

ZIP/Postal Code

08755

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Bronx

State/Province

New York

ZIP/Postal Code

10455

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Bronx

State/Province

New York

ZIP/Postal Code

10461

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Buffalo

State/Province

New York

ZIP/Postal Code

14215

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

New Windsor

State/Province

New York

ZIP/Postal Code

12553

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Potsdam

State/Province

New York

ZIP/Postal Code

13676

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Burlington

State/Province

North Carolina

ZIP/Postal Code

27215

Country

United States

Individual Site Status

Completed

Facility Name

Research Site

City

Chapel Hill

State/Province

North Carolina

ZIP/Postal Code

27517

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Charlotte

State/Province

North Carolina

ZIP/Postal Code

28277

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Charlotte

State/Province

North Carolina

ZIP/Postal Code

28287

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Elizabeth City

State/Province

North Carolina

ZIP/Postal Code

27909

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Gastonia

State/Province

North Carolina

ZIP/Postal Code

28054

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Huntersville

State/Province

North Carolina

ZIP/Postal Code

28078

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Mooresville

State/Province

North Carolina

ZIP/Postal Code

28117

Country

United States

Individual Site Status

Terminated

Facility Name

Research Site

City

New Bern

State/Province

North Carolina

ZIP/Postal Code

28562

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Wilmington

State/Province

North Carolina

ZIP/Postal Code

28401

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Winston-Salem

State/Province

North Carolina

ZIP/Postal Code

27103

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Fargo

State/Province

North Dakota

ZIP/Postal Code

58104

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Cincinnati

State/Province

Ohio

ZIP/Postal Code

45220

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Cleveland

State/Province

Ohio

ZIP/Postal Code

44106

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Cleveland

State/Province

Ohio

ZIP/Postal Code

44106

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Columbus

State/Province

Ohio

ZIP/Postal Code

43215

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Oklahoma City

State/Province

Oklahoma

ZIP/Postal Code

73106

Country

United States

Individual Site Status

Completed

Facility Name

Research Site

City

Happy Valley

State/Province

Oregon

ZIP/Postal Code

97086

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Medford

State/Province

Oregon

ZIP/Postal Code

97504

Country

United States

Individual Site Status

Completed

Facility Name

Research Site

City

Doylestown

State/Province

Pennsylvania

ZIP/Postal Code

18901

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

DuBois

State/Province

Pennsylvania

ZIP/Postal Code

15801

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Philadelphia

State/Province

Pennsylvania

ZIP/Postal Code

19140

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Pittsburgh

State/Province

Pennsylvania

ZIP/Postal Code

15213

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Smithfield

State/Province

Pennsylvania

ZIP/Postal Code

15478

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Charleston

State/Province

South Carolina

ZIP/Postal Code

29407

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Greenville

State/Province

South Carolina

ZIP/Postal Code

29615

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Mount Pleasant

State/Province

South Carolina

ZIP/Postal Code

29464

Country

United States

Individual Site Status

Terminated

Facility Name

Research Site

City

North Charleston

State/Province

South Carolina

ZIP/Postal Code

29406

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Rock Hill

State/Province

South Carolina

ZIP/Postal Code

29732

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Spartanburg

State/Province

South Carolina

ZIP/Postal Code

29303

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Rapid City

State/Province

South Dakota

ZIP/Postal Code

57702

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Chattanooga

State/Province

Tennessee

ZIP/Postal Code

37404

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Franklin

State/Province

Tennessee

ZIP/Postal Code

37067

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Hendersonville

State/Province

Tennessee

ZIP/Postal Code

37075

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Johnson City

State/Province

Tennessee

ZIP/Postal Code

37601

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Amarillo

State/Province

Texas

ZIP/Postal Code

79106

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Amarillo

State/Province

Texas

ZIP/Postal Code

79124

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Cypress

State/Province

Texas

ZIP/Postal Code

77429

Country

United States

Individual Site Status

Suspended

Facility Name

Research Site

City

Dallas

State/Province

Texas

ZIP/Postal Code

75390

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Fort Worth

State/Province

Texas

ZIP/Postal Code

76104

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Houston

State/Province

Texas

ZIP/Postal Code

77079

Country

United States

Individual Site Status

Completed

Facility Name

Research Site

City

Kerrville

State/Province

Texas

ZIP/Postal Code

78028

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

San Antonio

State/Province

Texas

ZIP/Postal Code

78258

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Spring

State/Province

Texas

ZIP/Postal Code

77380

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Tomball

State/Province

Texas

ZIP/Postal Code

77375

Country

United States

Individual Site Status

Terminated

Facility Name

Research Site

City

Weatherford

State/Province

Texas

ZIP/Postal Code

76086

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Salt Lake City

State/Province

Utah

ZIP/Postal Code

84102

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

White River Junction

State/Province

Vermont

ZIP/Postal Code

05009

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Abingdon

State/Province

Virginia

ZIP/Postal Code

24210

Country

United States

Individual Site Status

Completed

Facility Name

Research Site

City

Salem

State/Province

Virginia

ZIP/Postal Code

24153

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Williamsburg

State/Province

Virginia

ZIP/Postal Code

23188

Country

United States

Individual Site Status

Active, not recruiting

Facility Name

Research Site

City

Everett

State/Province

Washington

ZIP/Postal Code

98208

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Everett

State/Province

Washington

ZIP/Postal Code

98208

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Spokane

State/Province

Washington

ZIP/Postal Code

99204

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Morgantown

State/Province

West Virginia

ZIP/Postal Code

26505

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Cudahy

State/Province

Wisconsin

ZIP/Postal Code

53110

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Milwaukee

State/Province

Wisconsin

ZIP/Postal Code

53295

Country

United States

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Buenos Aires

ZIP/Postal Code

S2000PBJ

Country

Argentina

Individual Site Status

Recruiting

Facility Name

Research Site

City

Caba

ZIP/Postal Code

C1012AAR

Country

Argentina

Individual Site Status

Recruiting

Facility Name

Research Site

City

Ciudad Autónoma de Buenos Aire

ZIP/Postal Code

C1440BRR

Country

Argentina

Individual Site Status

Terminated

Facility Name

Research Site

City

Ciudad de Buenos Aires

ZIP/Postal Code

1425

Country

Argentina

Individual Site Status

Recruiting

Facility Name

Research Site

City

Córdoba

ZIP/Postal Code

X5003DCE

Country

Argentina

Individual Site Status

Recruiting

Facility Name

Research Site

City

Florencio Varela

ZIP/Postal Code

1888

Country

Argentina

Individual Site Status

Recruiting

Facility Name

Research Site

City

Florida

ZIP/Postal Code

B1602DQD

Country

Argentina

Individual Site Status

Recruiting

Facility Name

Research Site

City

Mar del Plata

ZIP/Postal Code

B7600GWV

Country

Argentina

Individual Site Status

Recruiting

Facility Name

Research Site

City

Mendoza

ZIP/Postal Code

M5500GIP

Country

Argentina

Individual Site Status

Recruiting

Facility Name

Research Site

City

San Fernando

ZIP/Postal Code

B1646EBJ

Country

Argentina

Individual Site Status

Recruiting

Facility Name

Research Site

City

San Miguel de Tucuman

ZIP/Postal Code

4000

Country

Argentina

Individual Site Status

Recruiting

Facility Name

Research Site

City

Caringbah

ZIP/Postal Code

2229

Country

Australia

Individual Site Status

Recruiting

Facility Name

Research Site

City

Melbourne

ZIP/Postal Code

3004

Country

Australia

Individual Site Status

Recruiting

Facility Name

Research Site

City

South Brisbane

ZIP/Postal Code

4101

Country

Australia

Individual Site Status

Recruiting

Facility Name

Research Site

City

Southport

ZIP/Postal Code

4215

Country

Australia

Individual Site Status

Recruiting

Facility Name

Research Site

City

Spearwood

ZIP/Postal Code

6163

Country

Australia

Individual Site Status

Recruiting

Facility Name

Research Site

City

Bad Ischl

ZIP/Postal Code

4820

Country

Austria

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Bludenz

ZIP/Postal Code

6700

Country

Austria

Individual Site Status

Recruiting

Facility Name

Research Site

City

Feldbach

ZIP/Postal Code

A-8330

Country

Austria

Individual Site Status

Recruiting

Facility Name

Research Site

City

Grieskirchen

ZIP/Postal Code

4710

Country

Austria

Individual Site Status

Recruiting

Facility Name

Research Site

City

Linz

ZIP/Postal Code

4020

Country

Austria

Individual Site Status

Recruiting

Facility Name

Research Site

City

Thalheim

ZIP/Postal Code

4600

Country

Austria

Individual Site Status

Terminated

Facility Name

Research Site

City

Edegem

ZIP/Postal Code

2650

Country

Belgium

Individual Site Status

Recruiting

Facility Name

Research Site

City

Erpent

ZIP/Postal Code

5101

Country

Belgium

Individual Site Status

Recruiting

Facility Name

Research Site

City

Yvoir

ZIP/Postal Code

5530

Country

Belgium

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Blumenau

ZIP/Postal Code

89030-101

Country

Brazil

Individual Site Status

Recruiting

Facility Name

Research Site

City

Botucatu

ZIP/Postal Code

18.618-686

Country

Brazil

Individual Site Status

Recruiting

Facility Name

Research Site

City

Florianópolis

ZIP/Postal Code

88036-800

Country

Brazil

Individual Site Status

Terminated

Facility Name

Research Site

City

Maringa

ZIP/Postal Code

87015-000

Country

Brazil

Individual Site Status

Recruiting

Facility Name

Research Site

City

Porto Alegre

ZIP/Postal Code

9002-060

Country

Brazil

Individual Site Status

Recruiting

Facility Name

Research Site

City

Porto Alegre

ZIP/Postal Code

90020-090

Country

Brazil

Individual Site Status

Recruiting

Facility Name

Research Site

City

Porto Alegre

ZIP/Postal Code

90610-000

Country

Brazil

Individual Site Status

Recruiting

Facility Name

Research Site

City

Porto Alegre

ZIP/Postal Code

91350-200

Country

Brazil

Individual Site Status

Recruiting

Facility Name

Research Site

City

Santo Andre

ZIP/Postal Code

09080-110

Country

Brazil

Individual Site Status

Recruiting

Facility Name

Research Site

City

Sao Bernardo do Campo

ZIP/Postal Code

09750-420

Country

Brazil

Individual Site Status

Recruiting

Facility Name

Research Site

City

Sao Paulo

ZIP/Postal Code

05403-000

Country

Brazil

Individual Site Status

Recruiting

Facility Name

Research Site

City

Sorocaba

ZIP/Postal Code

18040-425

Country

Brazil

Individual Site Status

Recruiting

Facility Name

Research Site

City

Uberlandia

ZIP/Postal Code

38411-186

Country

Brazil

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Kozloduy

ZIP/Postal Code

3320

Country

Bulgaria

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Ruse

ZIP/Postal Code

7002

Country

Bulgaria

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Stara Zagora

ZIP/Postal Code

6000

Country

Bulgaria

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Calgary

State/Province

Alberta

ZIP/Postal Code

T3B 0M3

Country

Canada

Individual Site Status

Recruiting

Facility Name

Research Site

City

Edmonton

State/Province

Alberta

ZIP/Postal Code

T5J 3S9

Country

Canada

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Kelowna

State/Province

British Columbia

ZIP/Postal Code

V1Y 3H5

Country

Canada

Individual Site Status

Withdrawn

Facility Name

Research Site

City

St. John's

State/Province

ZIP/Postal Code

A1A 3R5

Country

Canada

Individual Site Status

Terminated

Facility Name

Research Site

City

Bridgewater

State/Province

Nova Scotia

ZIP/Postal Code

B4V 3N2

Country

Canada

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Lower Sackville

State/Province

Nova Scotia

ZIP/Postal Code

B4C 2S4

Country

Canada

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Ajax

State/Province

Ontario

ZIP/Postal Code

L1S 2J5

Country

Canada

Individual Site Status

Recruiting

Facility Name

Research Site

City

Barrie

State/Province

Ontario

ZIP/Postal Code

L4M 6M2

Country

Canada

Individual Site Status

Terminated

Facility Name

Research Site

City

Sarnia

State/Province

Ontario

ZIP/Postal Code

N7T 4X3

Country

Canada

Individual Site Status

Terminated

Facility Name

Research Site

City

Stouffville

State/Province

Ontario

ZIP/Postal Code

L4A 1H2

Country

Canada

Individual Site Status

Recruiting

Facility Name

Research Site

City

Toronto

State/Province

Ontario

ZIP/Postal Code

M5T 3A9

Country

Canada

Individual Site Status

Recruiting

Facility Name

Research Site

City

Toronto

State/Province

Ontario

ZIP/Postal Code

M9V 4B4

Country

Canada

Individual Site Status

Terminated

Facility Name

Research Site

City

Montreal

State/Province

Quebec

ZIP/Postal Code

H4A 3J1

Country

Canada

Individual Site Status

Recruiting

Facility Name

Research Site

City

Saskatoon

State/Province

Saskatchewan

ZIP/Postal Code

S7N 0W8

Country

Canada

Individual Site Status

Recruiting

Facility Name

Research Site

City

Chicoutimi

ZIP/Postal Code

G7H 5H6

Country

Canada

Individual Site Status

Recruiting

Facility Name

Research Site

City

Quebec

ZIP/Postal Code

G1V 4W2

Country

Canada

Individual Site Status

Recruiting

Facility Name

Research Site

City

Quebec

ZIP/Postal Code

G1W 4R4

Country

Canada

Individual Site Status

Terminated

Facility Name

Research Site

City

Quebec

ZIP/Postal Code

G2J 0C4

Country

Canada

Individual Site Status

Recruiting

Facility Name

Research Site

City

Curico

ZIP/Postal Code

3341643

Country

Chile

Individual Site Status

Recruiting

Facility Name

Research Site

City

Quillota

ZIP/Postal Code

2260000

Country

Chile

Individual Site Status

Recruiting

Facility Name

Research Site

City

Santiago

ZIP/Postal Code

7500571

Country

Chile

Individual Site Status

Terminated

Facility Name

Research Site

City

Santiago

ZIP/Postal Code

7500692

Country

Chile

Individual Site Status

Recruiting

Facility Name

Research Site

City

Santiago

ZIP/Postal Code

7500698

Country

Chile

Individual Site Status

Terminated

Facility Name

Research Site

City

Santiago

ZIP/Postal Code

8380453

Country

Chile

Individual Site Status

Recruiting

Facility Name

Research Site

City

Talca

ZIP/Postal Code

3465584

Country

Chile

Individual Site Status

Recruiting

Facility Name

Research Site

City

Viña del Mar

ZIP/Postal Code

2520997

Country

Chile

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Baotou

ZIP/Postal Code

14010

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Beijing

ZIP/Postal Code

100034

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Beijing

ZIP/Postal Code

102218

Country

China

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Changsha

ZIP/Postal Code

410005

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Changsha

ZIP/Postal Code

410015

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Changsha

ZIP/Postal Code

430033

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Chengdu

ZIP/Postal Code

610041

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Chengdu

ZIP/Postal Code

610072

Country

China

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Chongqing

ZIP/Postal Code

402260

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Ganzhou

ZIP/Postal Code

341000

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Guangzhou

ZIP/Postal Code

510180

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Guangzhou

ZIP/Postal Code

510630

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Guiyang

ZIP/Postal Code

550002

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Haikou

ZIP/Postal Code

570311

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Hangzhou

ZIP/Postal Code

310006

Country

China

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Hebei

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Hefei

ZIP/Postal Code

230001

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Hohhot

ZIP/Postal Code

010017

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Hohhot

ZIP/Postal Code

10050

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kunming

ZIP/Postal Code

650032

Country

China

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Linhai

ZIP/Postal Code

317000

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Nanchang

ZIP/Postal Code

330006

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Nanjing

ZIP/Postal Code

210011

Country

China

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Nanjing

ZIP/Postal Code

210012

Country

China

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Shanghai

ZIP/Postal Code

200002

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Shanghai

ZIP/Postal Code

200032

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Shanghai

ZIP/Postal Code

200092

Country

China

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Shanghai

ZIP/Postal Code

200240

Country

China

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Shanghai

ZIP/Postal Code

200433

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Shenyang

ZIP/Postal Code

100003

Country

China

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Shenyang

ZIP/Postal Code

110015

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Shenzhen

ZIP/Postal Code

518020

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Shenzhen

ZIP/Postal Code

518039

Country

China

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Shijiazhuang

ZIP/Postal Code

50051

Country

China

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Suzhou

ZIP/Postal Code

215000

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Urumqi

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Wenzhou

ZIP/Postal Code

325027

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Wuhan

ZIP/Postal Code

430030

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Wuhan

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Xi'an

ZIP/Postal Code

710061

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Yangzhou

ZIP/Postal Code

225000

Country

China

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Yanji

ZIP/Postal Code

133000

Country

China

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Yinchuan

ZIP/Postal Code

750001

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Yinchuan

ZIP/Postal Code

750004

Country

China

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Yiyang

ZIP/Postal Code

413000

Country

China

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Zhanjiang

ZIP/Postal Code

524001

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Zhengzhou

ZIP/Postal Code

450003

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Barranquilla

ZIP/Postal Code

80007

Country

Colombia

Individual Site Status

Recruiting

Facility Name

Research Site

City

Cali

ZIP/Postal Code

76001000

Country

Colombia

Individual Site Status

Recruiting

Facility Name

Research Site

City

Floridablanca

ZIP/Postal Code

681004

Country

Colombia

Individual Site Status

Recruiting

Facility Name

Research Site

City

Medellin

ZIP/Postal Code

050621

Country

Colombia

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Medellin

ZIP/Postal Code

5001000

Country

Colombia

Individual Site Status

Recruiting

Facility Name

Research Site

City

Pereira

ZIP/Postal Code

660003

Country

Colombia

Individual Site Status

Recruiting

Facility Name

Research Site

City

Rionegro

ZIP/Postal Code

54048

Country

Colombia

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Zipaquira

ZIP/Postal Code

200251

Country

Colombia

Individual Site Status

Recruiting

Facility Name

Research Site

City

Brandys nad Labem

ZIP/Postal Code

250 01

Country

Czechia

Individual Site Status

Active, not recruiting

Facility Name

Research Site

City

Jindrichuv Hradec

ZIP/Postal Code

377 01

Country

Czechia

Individual Site Status

Completed

Facility Name

Research Site

City

Ostrava

ZIP/Postal Code

708 68

Country

Czechia

Individual Site Status

Completed

Facility Name

Research Site

City

Rokycany

ZIP/Postal Code

337 22

Country

Czechia

Individual Site Status

Active, not recruiting

Facility Name

Research Site

City

Teplice

ZIP/Postal Code

415 01

Country

Czechia

Individual Site Status

Completed

Facility Name

Research Site

City

Hvidovre

ZIP/Postal Code

2650

Country

Denmark

Individual Site Status

Recruiting

Facility Name

Research Site

City

København NV

ZIP/Postal Code

2400

Country

Denmark

Individual Site Status

Recruiting

Facility Name

Research Site

City

Odense C

ZIP/Postal Code

5000

Country

Denmark

Individual Site Status

Recruiting

Facility Name

Research Site

City

Roskilde

ZIP/Postal Code

4000

Country

Denmark

Individual Site Status

Recruiting

Facility Name

Research Site

City

Vejle

ZIP/Postal Code

7100

Country

Denmark

Individual Site Status

Recruiting

Facility Name

Research Site

City

Ålborg

ZIP/Postal Code

9000

Country

Denmark

Individual Site Status

Recruiting

Facility Name

Research Site

City

Aachen

ZIP/Postal Code

52074

Country

Germany

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Bamberg

ZIP/Postal Code

96049

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Berlin

ZIP/Postal Code

10717

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Berlin

ZIP/Postal Code

12157

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Berlin

ZIP/Postal Code

13187

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Darmstadt

ZIP/Postal Code

64283

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Hamburg

ZIP/Postal Code

20354

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Hannover

ZIP/Postal Code

D-30173

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Koblenz

ZIP/Postal Code

56068

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Köln

ZIP/Postal Code

51069

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Leipzig

ZIP/Postal Code

04103

Country

Germany

Individual Site Status

Terminated

Facility Name

Research Site

City

Leipzig

ZIP/Postal Code

04207

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Leipzig

ZIP/Postal Code

04357

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Marburg

ZIP/Postal Code

35037

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Marburg

ZIP/Postal Code

35037

Country

Germany

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Neu-Isenburg

ZIP/Postal Code

63263

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Peine

ZIP/Postal Code

31224

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Potsdam

ZIP/Postal Code

14467

Country

Germany

Individual Site Status

Completed

Facility Name

Research Site

City

Rheine

ZIP/Postal Code

48431

Country

Germany

Individual Site Status

Terminated

Facility Name

Research Site

City

Warendorf

ZIP/Postal Code

48231

Country

Germany

Individual Site Status

Terminated

Facility Name

Research Site

City

Athens

ZIP/Postal Code

10676

Country

Greece

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Athens

ZIP/Postal Code

11527

Country

Greece

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Athens

ZIP/Postal Code

11527

Country

Greece

Individual Site Status

Recruiting

Facility Name

Research Site

City

Athens

ZIP/Postal Code

12462

Country

Greece

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Exohi Thessaloniki

ZIP/Postal Code

57010

Country

Greece

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Heraklion

ZIP/Postal Code

71110

Country

Greece

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Ioannina

ZIP/Postal Code

45500

Country

Greece

Individual Site Status

Recruiting

Facility Name

Research Site

City

Thessaloniki

ZIP/Postal Code

56429

Country

Greece

Individual Site Status

Completed

Facility Name

Research Site

City

Thessaloniki

ZIP/Postal Code

57010

Country

Greece

Individual Site Status

Recruiting

Facility Name

Research Site

City

Balassagyarmat

ZIP/Postal Code

2660

Country

Hungary

Individual Site Status

Recruiting

Facility Name

Research Site

City

Budapest

ZIP/Postal Code

1033

Country

Hungary

Individual Site Status

Terminated

Facility Name

Research Site

City

Edelény

ZIP/Postal Code

3780

Country

Hungary

Individual Site Status

Recruiting

Facility Name

Research Site

City

Encs

ZIP/Postal Code

3860

Country

Hungary

Individual Site Status

Recruiting

Facility Name

Research Site

City

Gödöllő

ZIP/Postal Code

2100

Country

Hungary

Individual Site Status

Recruiting

Facility Name

Research Site

City

Hajdúnánás

ZIP/Postal Code

4080

Country

Hungary

Individual Site Status

Recruiting

Facility Name

Research Site

City

Komárom

ZIP/Postal Code

2900

Country

Hungary

Individual Site Status

Recruiting

Facility Name

Research Site

City

Pécs

ZIP/Postal Code

7635

Country

Hungary

Individual Site Status

Terminated

Facility Name

Research Site

City

Siófok

ZIP/Postal Code

8600

Country

Hungary

Individual Site Status

Terminated

Facility Name

Research Site

City

Szeged

ZIP/Postal Code

6722

Country

Hungary

Individual Site Status

Terminated

Facility Name

Research Site

City

Százhalombatta

ZIP/Postal Code

2440

Country

Hungary

Individual Site Status

Recruiting

Facility Name

Research Site

City

Törökbálint

ZIP/Postal Code

2045

Country

Hungary

Individual Site Status

Terminated

Facility Name

Research Site

City

Ahmedabad

ZIP/Postal Code

380006

Country

India

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Ansari Nagar

ZIP/Postal Code

110 029

Country

India

Individual Site Status

Suspended

Facility Name

Research Site

City

Calicut

ZIP/Postal Code

673 008

Country

India

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Chennai

ZIP/Postal Code

600116

Country

India

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Coimbatore

ZIP/Postal Code

641028

Country

India

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Delhi

ZIP/Postal Code

110029

Country

India

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Guntur

ZIP/Postal Code

522005

Country

India

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Hyderabad

ZIP/Postal Code

500038

Country

India

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Jaipur

ZIP/Postal Code

302039

Country

India

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Pune

ZIP/Postal Code

411047

Country

India

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Thane

ZIP/Postal Code

401107

Country

India

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Vijayawada

ZIP/Postal Code

520 008

Country

India

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Catanzaro

ZIP/Postal Code

88100

Country

Italy

Individual Site Status

Suspended

Facility Name

Research Site

City

Cona

ZIP/Postal Code

44124

Country

Italy

Individual Site Status

Recruiting

Facility Name

Research Site

City

Genova

ZIP/Postal Code

16132

Country

Italy

Individual Site Status

Recruiting

Facility Name

Research Site

City

Milano

ZIP/Postal Code

20142

Country

Italy

Individual Site Status

Recruiting

Facility Name

Research Site

City

Milano

ZIP/Postal Code

20157

Country

Italy

Individual Site Status

Recruiting

Facility Name

Research Site

City

Napoli

ZIP/Postal Code

80131

Country

Italy

Individual Site Status

Recruiting

Facility Name

Research Site

City

Reggio Emilia

ZIP/Postal Code

42123

Country

Italy

Individual Site Status

Recruiting

Facility Name

Research Site

City

Roma

ZIP/Postal Code

00168

Country

Italy

Individual Site Status

Recruiting

Facility Name

Research Site

City

Rozzano

ZIP/Postal Code

20089

Country

Italy

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Chuo-ku

ZIP/Postal Code

103-0022

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Chuo-ku

ZIP/Postal Code

104-0031

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Chuo-ku

ZIP/Postal Code

104-0031

Country

Japan

Individual Site Status

Terminated

Facility Name

Research Site

City

Fukuoka-shi

ZIP/Postal Code

814-0180

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Himeji-shi

ZIP/Postal Code

672-8064

Country

Japan

Individual Site Status

Terminated

Facility Name

Research Site

City

Hitachinaka-shi

ZIP/Postal Code

312-0057

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Joyo-shi

ZIP/Postal Code

610-0113

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kasuga-shi

ZIP/Postal Code

816-0813

Country

Japan

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Kawachinagano-shi

ZIP/Postal Code

586-8521

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kishiwada-shi

ZIP/Postal Code

596-8501

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kobe-shi

ZIP/Postal Code

650-0047

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Koto-ku

ZIP/Postal Code

136-0075

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kure-shi

ZIP/Postal Code

737-0023

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Matsusaka-shi

ZIP/Postal Code

515-8544

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Meguro-ku

ZIP/Postal Code

152-8902

Country

Japan

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Mizunami-shi

ZIP/Postal Code

509-6134

Country

Japan

Individual Site Status

Active, not recruiting

Facility Name

Research Site

City

Nagaoka-shi

ZIP/Postal Code

940-2085

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Nagoya-shi

ZIP/Postal Code

457-8511

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Nishinomiya-shi

ZIP/Postal Code

663-8501

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Okayama-shi

ZIP/Postal Code

700-8558

Country

Japan

Individual Site Status

Terminated

Facility Name

Research Site

City

Osaka-shi

ZIP/Postal Code

531-0073

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Sagamihara-shi

ZIP/Postal Code

252-0315

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Sakai-shi

ZIP/Postal Code

591-8555

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Sakaide-shi

ZIP/Postal Code

762-8550

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Seto-shi

ZIP/Postal Code

489-8642

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Shinagawa-ku

ZIP/Postal Code

140-8522

Country

Japan

Individual Site Status

Terminated

Facility Name

Research Site

City

Shinagawa-ku

ZIP/Postal Code

142-8666

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Toshima-ku

ZIP/Postal Code

170-0002

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Toshima-ku

ZIP/Postal Code

170-0003

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Toshima-ku

ZIP/Postal Code

171-0014

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Toyonaka-shi

ZIP/Postal Code

560-8552

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Ueda-shi

ZIP/Postal Code

386-8610

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Yanagawa-shi

ZIP/Postal Code

832-0059

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Yokohama-shi

ZIP/Postal Code

223-0059

Country

Japan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Daegu

ZIP/Postal Code

42415

Country

Korea, Republic of

Individual Site Status

Recruiting

Facility Name

Research Site

City

Jeonju-si

ZIP/Postal Code

54907

Country

Korea, Republic of

Individual Site Status

Recruiting

Facility Name

Research Site

City

Seoul

ZIP/Postal Code

03312

Country

Korea, Republic of

Individual Site Status

Recruiting

Facility Name

Research Site

City

Seoul

ZIP/Postal Code

04401

Country

Korea, Republic of

Individual Site Status

Terminated

Facility Name

Research Site

City

Seoul

ZIP/Postal Code

05030

Country

Korea, Republic of

Individual Site Status

Recruiting

Facility Name

Research Site

City

Seoul

ZIP/Postal Code

06591

Country

Korea, Republic of

Individual Site Status

Recruiting

Facility Name

Research Site

City

Wonju-si

ZIP/Postal Code

26426

Country

Korea, Republic of

Individual Site Status

Recruiting

Facility Name

Research Site

City

Guadalajara

ZIP/Postal Code

44100

Country

Mexico

Individual Site Status

Recruiting

Facility Name

Research Site

City

Guadalajara

ZIP/Postal Code

44130

Country

Mexico

Individual Site Status

Recruiting

Facility Name

Research Site

City

Guadalajara

ZIP/Postal Code

44200

Country

Mexico

Individual Site Status

Recruiting

Facility Name

Research Site

City

Mexico

ZIP/Postal Code

07760

Country

Mexico

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Monterrey

ZIP/Postal Code

64460

Country

Mexico

Individual Site Status

Recruiting

Facility Name

Research Site

City

Mérida

ZIP/Postal Code

97070

Country

Mexico

Individual Site Status

Recruiting

Facility Name

Research Site

City

Veracruz

ZIP/Postal Code

91910

Country

Mexico

Individual Site Status

Recruiting

Facility Name

Research Site

City

Amersfoort

ZIP/Postal Code

3813 TZ

Country

Netherlands

Individual Site Status

Recruiting

Facility Name

Research Site

City

Breda

ZIP/Postal Code

4818 CK

Country

Netherlands

Individual Site Status

Recruiting

Facility Name

Research Site

City

Den Haag

ZIP/Postal Code

2512 VA

Country

Netherlands

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Leeuwarden

ZIP/Postal Code

8934 AD

Country

Netherlands

Individual Site Status

Recruiting

Facility Name

Research Site

City

Auckland

ZIP/Postal Code

0626

Country

New Zealand

Individual Site Status

Recruiting

Facility Name

Research Site

City

Auckland

ZIP/Postal Code

1051

Country

New Zealand

Individual Site Status

Recruiting

Facility Name

Research Site

City

Christchurch

ZIP/Postal Code

8024

Country

New Zealand

Individual Site Status

Recruiting

Facility Name

Research Site

City

Dunedin

ZIP/Postal Code

9016

Country

New Zealand

Individual Site Status

Recruiting

Facility Name

Research Site

City

Hamilton

ZIP/Postal Code

3204

Country

New Zealand

Individual Site Status

Recruiting

Facility Name

Research Site

City

Cavite City

ZIP/Postal Code

4114

Country

Philippines

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Iloilo City

ZIP/Postal Code

5000

Country

Philippines

Individual Site Status

Recruiting

Facility Name

Research Site

City

Los Baños

ZIP/Postal Code

4030

Country

Philippines

Individual Site Status

Recruiting

Facility Name

Research Site

City

Marilao

ZIP/Postal Code

3019

Country

Philippines

Individual Site Status

Recruiting

Facility Name

Research Site

City

Quezon City

ZIP/Postal Code

1100

Country

Philippines

Individual Site Status

Recruiting

Facility Name

Research Site

City

Białystok

ZIP/Postal Code

15-044

Country

Poland

Individual Site Status

Recruiting

Facility Name

Research Site

City

Grodzisk Mazowiecki

ZIP/Postal Code

05-825

Country

Poland

Individual Site Status

Recruiting

Facility Name

Research Site

City

Katowice

ZIP/Postal Code

40-648

Country

Poland

Individual Site Status

Recruiting

Facility Name

Research Site

City

Krakow

ZIP/Postal Code

30-727

Country

Poland

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Ostrowiec Świętokrzyski

ZIP/Postal Code

27-400

Country

Poland

Individual Site Status

Recruiting

Facility Name

Research Site

City

Poznań

ZIP/Postal Code

60-693

Country

Poland

Individual Site Status

Recruiting

Facility Name

Research Site

City

Poznań

ZIP/Postal Code

61-578

Country

Poland

Individual Site Status

Recruiting

Facility Name

Research Site

City

Proszowice

ZIP/Postal Code

32-100

Country

Poland

Individual Site Status

Terminated

Facility Name

Research Site

City

Rzeszów

ZIP/Postal Code

35-051

Country

Poland

Individual Site Status

Recruiting

Facility Name

Research Site

City

Skierniewice

ZIP/Postal Code

96-100

Country

Poland

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Warszawa

ZIP/Postal Code

02-793

Country

Poland

Individual Site Status

Terminated

Facility Name

Research Site

City

Wieluń

ZIP/Postal Code

98-300

Country

Poland

Individual Site Status

Terminated

Facility Name

Research Site

City

Łódź

ZIP/Postal Code

90-153

Country

Poland

Individual Site Status

Recruiting

Facility Name

Research Site

City

Caguas

ZIP/Postal Code

00726

Country

Puerto Rico

Individual Site Status

Recruiting

Facility Name

Research Site

City

San Juan

ZIP/Postal Code

00918

Country

Puerto Rico

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Barcelona

ZIP/Postal Code

08017

Country

Spain

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Hospitalet de Llobregat(Barcel

ZIP/Postal Code

08907

Country

Spain

Individual Site Status

Recruiting

Facility Name

Research Site

City

Laredo

ZIP/Postal Code

39770

Country

Spain

Individual Site Status

Completed

Facility Name

Research Site

City

Madrid

ZIP/Postal Code

28007

Country

Spain

Individual Site Status

Recruiting

Facility Name

Research Site

City

Madrid

ZIP/Postal Code

28046

Country

Spain

Individual Site Status

Recruiting

Facility Name

Research Site

City

Madrid

ZIP/Postal Code

28850

Country

Spain

Individual Site Status

Recruiting

Facility Name

Research Site

City

Malaga

ZIP/Postal Code

29010

Country

Spain

Individual Site Status

Recruiting

Facility Name

Research Site

City

Santander

ZIP/Postal Code

39008

Country

Spain

Individual Site Status

Recruiting

Facility Name

Research Site

City

Göteborg

ZIP/Postal Code

413 45

Country

Sweden

Individual Site Status

Recruiting

Facility Name

Research Site

City

Göteborg

ZIP/Postal Code

413 46

Country

Sweden

Individual Site Status

Recruiting

Facility Name

Research Site

City

Helsingborg

ZIP/Postal Code

25220

Country

Sweden

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Lund

ZIP/Postal Code

222 22

Country

Sweden

Individual Site Status

Recruiting

Facility Name

Research Site

City

Malmö

ZIP/Postal Code

205 02

Country

Sweden

Individual Site Status

Recruiting

Facility Name

Research Site

City

Stockholm

ZIP/Postal Code

114 46

Country

Sweden

Individual Site Status

Recruiting

Facility Name

Research Site

City

Adana

ZIP/Postal Code

01330

Country

Turkey

Individual Site Status

Recruiting

Facility Name

Research Site

City

Ankara

ZIP/Postal Code

Country

Turkey

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Antalya

ZIP/Postal Code

07070

Country

Turkey

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Istanbul

ZIP/Postal Code

34098

Country

Turkey

Individual Site Status

Recruiting

Facility Name

Research Site

City

İstanbul

ZIP/Postal Code

34844

Country

Turkey

Individual Site Status

Recruiting

Facility Name

Research Site

City

Izmir

ZIP/Postal Code

35110

Country

Turkey

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kocaeli

ZIP/Postal Code

41380

Country

Turkey

Individual Site Status

Recruiting

Facility Name

Research Site

City

Mersin

ZIP/Postal Code

33343

Country

Turkey

Individual Site Status

Recruiting

Facility Name

Research Site

City

Barnsley

ZIP/Postal Code

S75 3DL

Country

United Kingdom

Individual Site Status

Recruiting

Facility Name

Research Site

City

Birmingham

ZIP/Postal Code

B9 5SS

Country

United Kingdom

Individual Site Status

Recruiting

Facility Name

Research Site

City

Blackpool

ZIP/Postal Code

FY2 0JH

Country

United Kingdom

Individual Site Status

Recruiting

Facility Name

Research Site

City

Bradford

ZIP/Postal Code

BD9 6RJ

Country

United Kingdom

Individual Site Status

Recruiting

Facility Name

Research Site

City

Chertsey

ZIP/Postal Code

KT16 0PZ

Country

United Kingdom

Individual Site Status

Active, not recruiting

Facility Name

Research Site

City

Cottingham

ZIP/Postal Code

HU16 5JQ

Country

United Kingdom

Individual Site Status

Recruiting

Facility Name

Research Site

City

Larbert

ZIP/Postal Code

FK5 4WR

Country

United Kingdom

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Leicester

ZIP/Postal Code

LE3 9QP

Country

United Kingdom

Individual Site Status

Recruiting

Facility Name

Research Site

City

Manchester

ZIP/Postal Code

M13 9NQ

Country

United Kingdom

Individual Site Status

Recruiting

Facility Name

Research Site

City

Oxford

ZIP/Postal Code

OX3 7LE

Country

United Kingdom

Individual Site Status

Recruiting

Facility Name

Research Site

City

Perth

ZIP/Postal Code

PH1 1NX

Country

United Kingdom

Individual Site Status

Recruiting

Facility Name

Research Site

City

Southampton

ZIP/Postal Code

SO166YD

Country

United Kingdom

Individual Site Status

Recruiting

Facility Name

Research Site

City

Stockton-on-Tees

ZIP/Postal Code

TS17 6EW

Country

United Kingdom

Individual Site Status

Recruiting

Facility Name

Research Site

City

Wishaw

ZIP/Postal Code

ML2 0DP

Country

United Kingdom

Individual Site Status

Recruiting

Facility Name

Research Site

City

Hanoi

ZIP/Postal Code

100000

Country

Vietnam

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Ho Chi Minh city

ZIP/Postal Code

700000

Country

Vietnam

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Ho Chi Minh

ZIP/Postal Code

700000

Country

Vietnam

Individual Site Status

Not yet recruiting

12. IPD Sharing Statement

Plan to Share IPD

Yes

IPD Sharing Plan Description

Qualified researchers can request access to anonymized individual patient-level data from AstraZeneca group of companies sponsored clinical trials via the request portal. All request will be evaluated as per the AZ disclosure commitment.

IPD Sharing Time Frame

AstraZeneca will meet or exceed data availability as per the commitments made to the EFPIA Pharma Data Sharing Principles.

IPD Sharing Access Criteria

When a request has been approved AstraZeneca will provide access to the de-identified individual patient-level data in an approved sponsored tool . Signed Data Sharing Agreement (non-negotiable contract for data accessors) must be in place before accessing requested information. Additionally, all users will need to accept the terms and conditions of the SAS MSE to gain access.

IPD Sharing URL

https://astrazenecagroup-dt.pharmacm.com/DT/Home

Links:

URL

https://filehosting-v2.pharmacm.com/api/Attachment/Download?tenantId=80217111&parentIdentifier=D3251C00014&attachmentIdentifier=e179b7eb-c2d8-4b45-ad4d-14aef6dbee7a&fileName=RESOLUTE_Poster.pdf&versionIdentifier=

Description

This is a poster on the Resolute study.

Learn more about this trial

Efficacy and Safety of Benralizumab in Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) With a History of Frequent Exacerbations

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Efficacy and Safety of Benralizumab in Moderate to Very Severe Chronic Obstructive Pulmonary Disease (COPD) With a History of Frequent Exacerbations (RESOLUTE)

Chronic Obstructive Pulmonary Disease

About this trial

Eligibility Criteria

Sites / Locations

Arms of the Study

Arm 1

Arm 2

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

1. Study Identification

2. Study Status

3. Sponsor/Collaborators

4. Oversight

5. Study Description

6. Conditions and Keywords

7. Study Design

8. Arms, Groups, and Interventions

10. Eligibility

12. IPD Sharing Statement

Learn more about this trial