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Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations. (TITANIA)

Primary Purpose

Chronic Obstructive Pulmonary Disease (COPD)

Status

Recruiting

Phase

Phase 3

Locations

International

Study Type

Interventional

Intervention

Tozorakimab

Placebo

About this trial

This is an interventional treatment trial for Chronic Obstructive Pulmonary Disease (COPD) focused on measuring Chronic Obstructive Pulmonary Disease, COPD, tozorakimab, exacerbations, ICS, LABA/LAMA

Eligibility Criteria

40 Years - 130 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

Participant must be ≥ 40 years of age and capable of giving signed informed consent.
Documented diagnosis of COPD for at least one year prior to enrolment.
Post BD FEV1/FVC < 0.70 and post-BD FEV1 >20% of predicted normal value.
Documented history of ≥ 2 moderate or ≥ 1 severe COPD exacerbations within 12 months prior to enrolment.
Documented optimized inhaled dual or triple therapy at a stable dose for at least 3 months prior to enrolment.
Smoking history of ≥ 10 pack-years.
CAT total score ≥10, with each of the phlegm (sputum) and cough items with a score ≥ 2

Exclusion Criteria:

Clinically important pulmonary disease other than COPD.
Radiological findings suggestive of a respiratory disease other than COPD that is contributing to the participant's respiratory symptoms.
Current diagnosis of asthma, prior history of asthma, or asthma-COPD overlap. Childhood history of asthma is allowed and defined as asthma diagnosed and resolved before the age of 18.
Any unstable disorder, including, but not limited to, cardiovascular, gastrointestinal, hepatic, renal, neurological, musculoskeletal, infectious, endocrine, metabolic, haematological, psychiatric disorder, major physical and/or cognitive impairment that could affect safety, study findings or participants ability to complete the study.
COPD exacerbation, within 2 weeks prior to randomization, that was treated with systemic corticosteroids and/or antibiotics, and/or led to hospitalization.
Active significant infection within the 4 weeks prior to randomization, pneumonia within 6 weeks prior to randomization, or medical condition that predisposes the participant to infection.
Suspicion of, or confirmed, ongoing SARS-CoV-2 infection.
Significant COVID-19 illness within the 6 months prior to enrolment.
Unstable cardiovascular disorder.
Diagnosis of cor pulmonale, pulmonary arterial hypertension and/or right ventricular failure.
History of known immunodeficiency disorder, including a positive test for HIV-1 or HIV 2.
History of positive test or treatment for hepatitis B or hepatitis C (except for cured hepatitis C).
Evidence of active liver disease, including jaundice during screening.
Malignancy, current or within the past 5 years, except for adequately treated non-invasive basal cell and squamous cell carcinoma of the skin and cervical carcinoma-in-situ treated with apparent success more than one year prior to enrolment. Suspected malignancy or undefined neoplasms.
Participants who have evidence of active TB.
Participants that have previously received tozorakimab.
Any clinically significant abnormal findings in physical examination, vital signs, ECG, or laboratory testing during the screening period, which in the opinion of the investigator may put the participant at risk because of their participation in the study, or may influence the results of the study, or the participant's ability to complete the entire duration of the study.
Active vaping of any products within the 6 months prior to randomization and during the study.

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Experimental

Placebo Comparator

Arm Label

Tozorakimab Dose 1

Tozorakimab Dose 2

Placebo

Arm Description

Dosing subcutaneously tozorakimab Dose 1 and placebo

Dosing subcutaneously tozorakimab Dose 2

Dosing subcutaneously with equivalent volume to tozorakimab

Outcomes

Primary Outcome Measures

Annualized rate of moderate to severe COPD exacerbations in participants who are former smokers.

The primary endpoint will be assessed first in the primary population (former smokers with symptomatic COPD and a history of exacerbations, on optimised treatment with maintenance inhaled therapy [triple therapy, or dual therapy if triple is not considered appropriate]) and then assessed in the overall population of participants.

Secondary Outcome Measures

Annualized rate of moderate to severe COPD exacerbations in former or current smokers.

The annualized rate will be assessed in the overall population of participants including current and former smokers with symptomatic COPD and history of exacerbations, on optimised treatment with maintenance inhaled therapy.

Time to first moderate to severe COPD exacerbation in former smokers.

To explore the extent to which treatment with each dose of tozorakimab delays the time to first exacerbation compared with placebo in former smokers.

Mean change from baseline in pre-BD, pre-dose trough FEV1 (mL) in former smokers.

Change from baseline in pre-bronchodilator, pre dose trough FEV1 (mL) in former smokers.

Mean change from baseline in pre-BD, pre-dose trough FEV1 (mL) in the overall population of current and former smokers.

Change from baseline in pre-bronchodilator, pre dose trough FEV1 (mL) in the overall population of current and former smokers.

Percentage of responders achieving MCID in E-RS:COPD total score in former smokers

Responder analyses for E-RS:COPD total score at Week 52 based upon a ≥ 2 point improvement (decrease) from baseline in former smokers.

Percentage of responders achieving MCID in E-RS:COPD total score in the overall population of current and former smokers.

Responder analyses for E-RS:COPD total score at Week 52 based upon a ≥ 2 point improvement (decrease) from baseline in the overall population of current and former smokers.

Mean change from baseline in E-RS:COPD total score in former smokers.

Difference in mean change in E-RS:COPD total score from baseline in former smokers.

Mean change from baseline in E-RS:COPD total score in the overall population of current and former smokers.

Difference in mean change in E-RS:COPD total score from baseline in the overall population of current and former smokers.

Percentage of responders achieving MCID in SGRQ total score in former smokers.

Percentage of participants with a decrease in SGRQ total score of ≥ 4 points from baseline in former smokers.

Percentage of responders achieving MCID in SGRQ total score in the overall population of current and former smokers.

Percentage of participants with a decrease in SGRQ total score of ≥ 4 points from baseline in the overall population of current and former smokers.

Mean change from baseline in SGRQ total score from in former smokers.

Difference in mean change from baseline in SGRQ total score in former smokers.

Mean change from baseline in SGRQ total score from in the overall population of current and former smokers.

Difference in mean change from baseline in SGRQ total score in the overall population of current and former smokers.

Time to first severe COPD exacerbation in former smokers.

To evaluate hazard ratio of first severe COPD exacerbation in former smokers.

Annualized rate of severe COPD exacerbations in former smokers.

The rate ratio of severe COPD exacerbations will be assessed in former smokers.

Change from baseline in CAT total score.

Analyses of change from baseline in CAT total score in former smokers.

Percentage of participants with a decrease in CAT total score in former smokers.

Proportion of participants achieving MCID in CAT total score, a decrease in CAT total score of ≥ 2 points from baseline in former smokers.

Proportion of participants having ≥ 1 healthcare resource utilization type in former smokers.

Annualized rate of healthcare resource utilization in former smokers.

The change from baseline in mean number of puffs per day in rescue use in former smokers.

Difference in mean number of puffs per day from baseline.

Trough serum concentrations of tozorakimab.

Pharmacokinetics: concentrations of tozorakimab in trough serum.

Presence of anti-drug antibodies.

Immunogenicity: presence of tozorakimab anti-drug antibodies in blood serum.

Full Information

NCT ID

NCT05158387

First Posted

December 2, 2021

Last Updated

October 12, 2023

Sponsor

AstraZeneca

1. Study Identification

Unique Protocol Identification Number

NCT05158387

Brief Title

Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations.

Acronym

TITANIA

Official Title

A Phase III, Multicentre, Randomised, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Two Dose Regimens of Tozorakimab in Participants With Symptomatic Chronic Obstructive Pulmonary Disease (COPD) With a History of COPD Exacerbations (TITANIA)

Study Type

Interventional

2. Study Status

Record Verification Date

October 2023

Overall Recruitment Status

Recruiting

Study Start Date

February 7, 2022 (Actual)

Primary Completion Date

June 5, 2025 (Anticipated)

Study Completion Date

August 28, 2025 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

AstraZeneca

4. Oversight

Studies a U.S. FDA-regulated Drug Product

Yes

Studies a U.S. FDA-regulated Device Product

Data Monitoring Committee

Yes

5. Study Description

Brief Summary

The purpose of this Phase III study is to evaluate the efficacy and safety of tozorakimab Dose 1 and Dose 2 administered subcutaneously (SC) in adult participants with symptomatic COPD and history of ≥ 2 moderate or ≥ 1 severe exacerbation of COPD in the previous 12 months. Participants should be receiving optimised treatment with maintenance inhaled therapy (ICS/LABA/LAMA triple therapy, or dual therapy if triple is not considered appropriate) in stable doses throughout at least 3 months prior to enrolment.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Chronic Obstructive Pulmonary Disease (COPD)

Keywords

Chronic Obstructive Pulmonary Disease, COPD, tozorakimab, exacerbations, ICS, LABA/LAMA

7. Study Design

Primary Purpose

Treatment

Study Phase

Phase 3

Interventional Study Model

Parallel Assignment

Masking

ParticipantCare ProviderInvestigator

Masking Description

unblinded administrator/pharmacist

Allocation

Randomized

Enrollment

1060 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title

Tozorakimab Dose 1

Arm Type

Experimental

Arm Description

Dosing subcutaneously tozorakimab Dose 1 and placebo

Arm Title

Tozorakimab Dose 2

Arm Type

Experimental

Arm Description

Dosing subcutaneously tozorakimab Dose 2

Arm Title

Placebo

Arm Type

Placebo Comparator

Arm Description

Dosing subcutaneously with equivalent volume to tozorakimab

Intervention Type

Drug

Intervention Name(s)

Tozorakimab

Intervention Description

Administered subcutaneously tozorakimab Dose 1 and placebo through Week 52.

Intervention Type

Drug

Intervention Name(s)

Tozorakimab

Intervention Description

Administered subcutaneously tozorakimab Dose 2 through Week 52.

Intervention Type

Drug

Intervention Name(s)

Placebo

Intervention Description

Placebo administered subcutaneously, equivalent volume to tozorakimab through week 52.

Primary Outcome Measure Information:

Title

Annualized rate of moderate to severe COPD exacerbations in participants who are former smokers.

Description

Time Frame

over 52 weeks

Secondary Outcome Measure Information:

Title

Annualized rate of moderate to severe COPD exacerbations in former or current smokers.

Description

Time Frame

over 52 weeks

Title

Time to first moderate to severe COPD exacerbation in former smokers.

Description

To explore the extent to which treatment with each dose of tozorakimab delays the time to first exacerbation compared with placebo in former smokers.

Time Frame

over 52 weeks

Title

Mean change from baseline in pre-BD, pre-dose trough FEV1 (mL) in former smokers.

Description

Change from baseline in pre-bronchodilator, pre dose trough FEV1 (mL) in former smokers.

Time Frame

Week 52, or over 52 weeks

Title

Mean change from baseline in pre-BD, pre-dose trough FEV1 (mL) in the overall population of current and former smokers.

Description

Change from baseline in pre-bronchodilator, pre dose trough FEV1 (mL) in the overall population of current and former smokers.

Time Frame

Week 52, or over 52 weeks

Title

Percentage of responders achieving MCID in E-RS:COPD total score in former smokers

Description

Responder analyses for E-RS:COPD total score at Week 52 based upon a ≥ 2 point improvement (decrease) from baseline in former smokers.

Time Frame

Week 52

Title

Percentage of responders achieving MCID in E-RS:COPD total score in the overall population of current and former smokers.

Description

Responder analyses for E-RS:COPD total score at Week 52 based upon a ≥ 2 point improvement (decrease) from baseline in the overall population of current and former smokers.

Time Frame

Week 52

Title

Mean change from baseline in E-RS:COPD total score in former smokers.

Description

Difference in mean change in E-RS:COPD total score from baseline in former smokers.

Time Frame

over 52 weeks

Title

Mean change from baseline in E-RS:COPD total score in the overall population of current and former smokers.

Description

Difference in mean change in E-RS:COPD total score from baseline in the overall population of current and former smokers.

Time Frame

over 52 weeks

Title

Percentage of responders achieving MCID in SGRQ total score in former smokers.

Description

Percentage of participants with a decrease in SGRQ total score of ≥ 4 points from baseline in former smokers.

Time Frame

Week 52

Title

Percentage of responders achieving MCID in SGRQ total score in the overall population of current and former smokers.

Description

Percentage of participants with a decrease in SGRQ total score of ≥ 4 points from baseline in the overall population of current and former smokers.

Time Frame

Week 52

Title

Mean change from baseline in SGRQ total score from in former smokers.

Description

Difference in mean change from baseline in SGRQ total score in former smokers.

Time Frame

over 52 weeks

Title

Mean change from baseline in SGRQ total score from in the overall population of current and former smokers.

Description

Difference in mean change from baseline in SGRQ total score in the overall population of current and former smokers.

Time Frame

over 52 weeks

Title

Time to first severe COPD exacerbation in former smokers.

Description

To evaluate hazard ratio of first severe COPD exacerbation in former smokers.

Time Frame

over 52 weeks

Title

Annualized rate of severe COPD exacerbations in former smokers.

Description

The rate ratio of severe COPD exacerbations will be assessed in former smokers.

Time Frame

over 52 weeks

Title

Change from baseline in CAT total score.

Description

Analyses of change from baseline in CAT total score in former smokers.

Time Frame

Week 52

Title

Percentage of participants with a decrease in CAT total score in former smokers.

Description

Proportion of participants achieving MCID in CAT total score, a decrease in CAT total score of ≥ 2 points from baseline in former smokers.

Time Frame

Week 52

Title

Proportion of participants having ≥ 1 healthcare resource utilization type in former smokers.

Description

Proportion of participants having ≥ 1 healthcare resource utilization type in former smokers.

Time Frame

over 52 weeks

Title

Annualized rate of healthcare resource utilization in former smokers.

Description

Annualized rate of healthcare resource utilization in former smokers.

Time Frame

over 52 weeks

Title

The change from baseline in mean number of puffs per day in rescue use in former smokers.

Description

Difference in mean number of puffs per day from baseline.

Time Frame

over 52 weeks

Title

Trough serum concentrations of tozorakimab.

Description

Pharmacokinetics: concentrations of tozorakimab in trough serum.

Time Frame

over 52 weeks

Title

Presence of anti-drug antibodies.

Description

Immunogenicity: presence of tozorakimab anti-drug antibodies in blood serum.

Time Frame

over 60 weeks

10. Eligibility

Sex

All

Minimum Age & Unit of Time

40 Years

Maximum Age & Unit of Time

130 Years

Accepts Healthy Volunteers

Eligibility Criteria

Inclusion Criteria: Participant must be ≥ 40 years of age and capable of giving signed informed consent. Documented diagnosis of COPD for at least one year prior to enrolment. Post BD FEV1/FVC < 0.70 and post-BD FEV1 >20% of predicted normal value. Documented history of ≥ 2 moderate or ≥ 1 severe COPD exacerbations within 12 months prior to enrolment. Documented optimized inhaled dual or triple therapy at a stable dose for at least 3 months prior to enrolment. Smoking history of ≥ 10 pack-years. CAT total score ≥10, with each of the phlegm (sputum) and cough items with a score ≥ 2 Exclusion Criteria: Clinically important pulmonary disease other than COPD. Radiological findings suggestive of a respiratory disease other than COPD that is significantly contributing to the participant's respiratory symptoms. Current diagnosis of asthma, prior history of asthma, or asthma-COPD overlap. Childhood history of asthma is allowed and defined as asthma diagnosed and resolved before the age of 18. Any unstable disorder, including, but not limited to, cardiovascular, gastrointestinal, hepatic, renal, neurological, musculoskeletal, infectious, endocrine, metabolic, haematological, psychiatric disorder, major physical and/or cognitive impairment that could affect safety, study findings or participants ability to complete the study. COPD exacerbation, within 2 weeks prior to randomization, that was treated with systemic corticosteroids and/or antibiotics, and/or led to hospitalization. Active significant infection within the 4 weeks prior to randomization, pneumonia within 6 weeks prior to randomization, or medical condition that predisposes the participant to infection. Suspicion of, or confirmed, ongoing SARS-CoV-2 infection. Significant COVID-19 illness within the 6 months prior to enrolment. Unstable cardiovascular disorder. Diagnosis of cor pulmonale, pulmonary arterial hypertension and/or right ventricular failure. History of known immunodeficiency disorder, including a positive test for HIV-1 or HIV 2. History of positive test or treatment for hepatitis B or hepatitis C (except for cured hepatitis C) Evidence of active liver disease, including jaundice during screening. Malignancy, current or within the past 5 years, except for adequately treated non-invasive basal cell and squamous cell carcinoma of the skin and cervical carcinoma-in-situ treated with apparent success more than one year prior to enrolment. Suspected malignancy or undefined neoplasms. Participants who have evidence of active TB. Participants that have previously received tozorakimab. Any clinically significant abnormal findings in physical examination, vital signs, ECG, or laboratory testing during the screening period, which in the opinion of the investigator may put the participant at risk because of their participation in the study, or may influence the results of the study, or the participant's ability to complete the entire duration of the study. Active vaping of any products or using smoked marijuana within the 6 months prior to randomization and during the study.

Central Contact Person:

First Name & Middle Initial & Last Name or Official Title & Degree

AstraZeneca Clinical Study Information Center

Phone

1-877-240-9479

information.center@astrazeneca.com

Facility Information:

Facility Name

Research Site

City

Sheffield

State/Province

Alabama

ZIP/Postal Code

35660

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Fullerton

State/Province

California

ZIP/Postal Code

92835

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Lincoln

State/Province

California

ZIP/Postal Code

95648

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Newport Beach

State/Province

California

ZIP/Postal Code

92663

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Northridge

State/Province

California

ZIP/Postal Code

91324

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

San Diego

State/Province

California

ZIP/Postal Code

92120

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Colorado Springs

State/Province

Colorado

ZIP/Postal Code

80909

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Newark

State/Province

Delaware

ZIP/Postal Code

19713

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Bay Pines

State/Province

Florida

ZIP/Postal Code

33744

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Cape Coral

State/Province

Florida

ZIP/Postal Code

33990

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Pensacola

State/Province

Florida

ZIP/Postal Code

32503

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Tampa

State/Province

Florida

ZIP/Postal Code

33607

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Winter Park

State/Province

Florida

ZIP/Postal Code

32789

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Macon

State/Province

Georgia

ZIP/Postal Code

31201

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Greenwood

State/Province

Indiana

ZIP/Postal Code

46143

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Bowling Green

State/Province

Kentucky

ZIP/Postal Code

42101

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

New Orleans

State/Province

Louisiana

ZIP/Postal Code

70112

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

White Marsh

State/Province

Maryland

ZIP/Postal Code

21162

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Boston

State/Province

Massachusetts

ZIP/Postal Code

02114

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

North Dartmouth

State/Province

Massachusetts

ZIP/Postal Code

02747

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Ann Arbor

State/Province

Michigan

ZIP/Postal Code

48109

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Farmington Hills

State/Province

Michigan

ZIP/Postal Code

48336

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Grand Rapids

State/Province

Michigan

ZIP/Postal Code

49546

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Hannibal

State/Province

Missouri

ZIP/Postal Code

63401

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Bellevue

State/Province

Nebraska

ZIP/Postal Code

68123

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Bronx

State/Province

New York

ZIP/Postal Code

10459

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Buffalo

State/Province

New York

ZIP/Postal Code

14203

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Toledo

State/Province

Ohio

ZIP/Postal Code

43617

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Oklahoma City

State/Province

Oklahoma

ZIP/Postal Code

73104

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Oklahoma City

State/Province

Oklahoma

ZIP/Postal Code

73112

Country

United States

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Tulsa

State/Province

Oklahoma

ZIP/Postal Code

74133

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Philadelphia

State/Province

Pennsylvania

ZIP/Postal Code

19140

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Rock Hill

State/Province

South Carolina

ZIP/Postal Code

29732

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Amarillo

State/Province

Texas

ZIP/Postal Code

79106

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Boerne

State/Province

Texas

ZIP/Postal Code

78006

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Fort Worth

State/Province

Texas

ZIP/Postal Code

76104

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

McKinney

State/Province

Texas

ZIP/Postal Code

75069

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Tomball

State/Province

Texas

ZIP/Postal Code

77375

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Webster

State/Province

Texas

ZIP/Postal Code

77598

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

West Valley City

State/Province

Utah

ZIP/Postal Code

84120

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Williamsburg

State/Province

Virginia

ZIP/Postal Code

23188

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Cudahy

State/Province

Wisconsin

ZIP/Postal Code

53110

Country

United States

Individual Site Status

Recruiting

Facility Name

Research Site

City

Adelaide

ZIP/Postal Code

5000

Country

Australia

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Campbelltown

ZIP/Postal Code

2560

Country

Australia

Individual Site Status

Recruiting

Facility Name

Research Site

City

Frankstown

ZIP/Postal Code

3199

Country

Australia

Individual Site Status

Recruiting

Facility Name

Research Site

City

Macquarie University

ZIP/Postal Code

2109

Country

Australia

Individual Site Status

Recruiting

Facility Name

Research Site

City

Melbourne

ZIP/Postal Code

3000

Country

Australia

Individual Site Status

Recruiting

Facility Name

Research Site

City

Nedlands

ZIP/Postal Code

6009

Country

Australia

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Southport

ZIP/Postal Code

4215

Country

Australia

Individual Site Status

Recruiting

Facility Name

Research Site

City

Spearwood

ZIP/Postal Code

6163

Country

Australia

Individual Site Status

Recruiting

Facility Name

Research Site

City

Wollongong

ZIP/Postal Code

2500

Country

Australia

Individual Site Status

Recruiting

Facility Name

Research Site

City

Woodville South

ZIP/Postal Code

5011

Country

Australia

Individual Site Status

Recruiting

Facility Name

Research Site

City

Blumenau

ZIP/Postal Code

89030-101

Country

Brazil

Individual Site Status

Recruiting

Facility Name

Research Site

City

Botucatu

ZIP/Postal Code

18618-686

Country

Brazil

Individual Site Status

Recruiting

Facility Name

Research Site

City

Brasilia

ZIP/Postal Code

71681-603

Country

Brazil

Individual Site Status

Recruiting

Facility Name

Research Site

City

Curitiba

ZIP/Postal Code

80440-220

Country

Brazil

Individual Site Status

Recruiting

Facility Name

Research Site

City

Porto Alegre

ZIP/Postal Code

90035074

Country

Brazil

Individual Site Status

Recruiting

Facility Name

Research Site

City

Porto Alegre

ZIP/Postal Code

9061-000

Country

Brazil

Individual Site Status

Recruiting

Facility Name

Research Site

City

Porto Alegre

ZIP/Postal Code

91010-006

Country

Brazil

Individual Site Status

Recruiting

Facility Name

Research Site

City

Rio de Janeiro

ZIP/Postal Code

22061-080

Country

Brazil

Individual Site Status

Recruiting

Facility Name

Research Site

City

Sao Bernardo do Campo

ZIP/Postal Code

09750-420

Country

Brazil

Individual Site Status

Recruiting

Facility Name

Research Site

City

Sao Paulo

ZIP/Postal Code

01323-903

Country

Brazil

Individual Site Status

Recruiting

Facility Name

Research Site

City

Sao Paulo

ZIP/Postal Code

05403-000

Country

Brazil

Individual Site Status

Recruiting

Facility Name

Research Site

City

São Paulo

ZIP/Postal Code

01409-001

Country

Brazil

Individual Site Status

Recruiting

Facility Name

Research Site

City

Curico

ZIP/Postal Code

3341643

Country

Chile

Individual Site Status

Recruiting

Facility Name

Research Site

City

Santiago

ZIP/Postal Code

7500010

Country

Chile

Individual Site Status

Recruiting

Facility Name

Research Site

City

Santiago

ZIP/Postal Code

7500657

Country

Chile

Individual Site Status

Recruiting

Facility Name

Research Site

City

Santiago

ZIP/Postal Code

7500698

Country

Chile

Individual Site Status

Recruiting

Facility Name

Research Site

City

Santiago

ZIP/Postal Code

8150000

Country

Chile

Individual Site Status

Recruiting

Facility Name

Research Site

City

Santiago

ZIP/Postal Code

8241479

Country

Chile

Individual Site Status

Recruiting

Facility Name

Research Site

City

Talca

ZIP/Postal Code

3465584

Country

Chile

Individual Site Status

Recruiting

Facility Name

Research Site

City

Anhui

ZIP/Postal Code

230061

Country

China

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Baotou

ZIP/Postal Code

014010

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Beijing

ZIP/Postal Code

100034

Country

China

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Beijing

ZIP/Postal Code

100144

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Beijing

ZIP/Postal Code

101200

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Changchun

ZIP/Postal Code

130021

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Changde

ZIP/Postal Code

415003

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Changsha

ZIP/Postal Code

410015

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Chengdu

ZIP/Postal Code

610000

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Chengdu

ZIP/Postal Code

610031

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Chengdu

ZIP/Postal Code

610083

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Chongqing

ZIP/Postal Code

400037

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Chongqing

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Guangzhou

ZIP/Postal Code

510120

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Guangzhou

ZIP/Postal Code

510180

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Guangzhou

ZIP/Postal Code

510630

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Haikou

ZIP/Postal Code

570311

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Hangzhou

ZIP/Postal Code

310006

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Hefei

ZIP/Postal Code

230001

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Hohhot

ZIP/Postal Code

010017

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kunming

ZIP/Postal Code

650032

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Linhai

ZIP/Postal Code

317000

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Nanchang

ZIP/Postal Code

330006

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Nanchang

ZIP/Postal Code

330006

Country

China

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Nanjing

ZIP/Postal Code

210000

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Nanjing

ZIP/Postal Code

210006

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Ningbo

ZIP/Postal Code

315010

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Shanghai

ZIP/Postal Code

200002

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Shanghai

ZIP/Postal Code

200032

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Shanghai

ZIP/Postal Code

200433

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Shanghai

ZIP/Postal Code

201199

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Shengyang

ZIP/Postal Code

110004

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Shenyang

ZIP/Postal Code

110016

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Shenzhen

ZIP/Postal Code

518020

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Shenzhen

ZIP/Postal Code

518053

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Shijiazhuang

ZIP/Postal Code

50051

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Suzhou

ZIP/Postal Code

215002

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Suzhou

ZIP/Postal Code

215004

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Taiyuan

ZIP/Postal Code

030001

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Tianjin

ZIP/Postal Code

300052

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Urumqi

ZIP/Postal Code

830054

Country

China

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Wuhan

ZIP/Postal Code

430022

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Wuxi

ZIP/Postal Code

214023

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Xiamen

ZIP/Postal Code

361004

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Xuzhou

ZIP/Postal Code

221000

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Xuzhou

ZIP/Postal Code

221009

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Yangzhou

ZIP/Postal Code

225001

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Yinchuan

ZIP/Postal Code

750001

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Yinchuan

ZIP/Postal Code

750004

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Zhanjiang

ZIP/Postal Code

524004

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Zunyi

ZIP/Postal Code

563100

Country

China

Individual Site Status

Recruiting

Facility Name

Research Site

City

Barranquilla

ZIP/Postal Code

80007

Country

Colombia

Individual Site Status

Recruiting

Facility Name

Research Site

City

Bogotá

ZIP/Postal Code

111211

Country

Colombia

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Ibague

ZIP/Postal Code

730006

Country

Colombia

Individual Site Status

Recruiting

Facility Name

Research Site

City

Medellin

ZIP/Postal Code

050034

Country

Colombia

Individual Site Status

Recruiting

Facility Name

Research Site

City

Rionegro

ZIP/Postal Code

54040

Country

Colombia

Individual Site Status

Recruiting

Facility Name

Research Site

City

Zipaquira

ZIP/Postal Code

200251

Country

Colombia

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Brest Cedex 2

ZIP/Postal Code

29609

Country

France

Individual Site Status

Recruiting

Facility Name

Research Site

City

Dijon Cedex

ZIP/Postal Code

21079

Country

France

Individual Site Status

Recruiting

Facility Name

Research Site

City

Grenoble cedex 9

ZIP/Postal Code

38043

Country

France

Individual Site Status

Recruiting

Facility Name

Research Site

City

Limoges

ZIP/Postal Code

87042

Country

France

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Lyon Cedex

ZIP/Postal Code

69317

Country

France

Individual Site Status

Recruiting

Facility Name

Research Site

City

Marseille

ZIP/Postal Code

13915

Country

France

Individual Site Status

Recruiting

Facility Name

Research Site

City

Montivilliers

ZIP/Postal Code

76290

Country

France

Individual Site Status

Recruiting

Facility Name

Research Site

City

Montpellier

Country

France

Individual Site Status

Recruiting

Facility Name

Research Site

City

Nantes

ZIP/Postal Code

44093

Country

France

Individual Site Status

Recruiting

Facility Name

Research Site

City

Pessac

ZIP/Postal Code

33604

Country

France

Individual Site Status

Recruiting

Facility Name

Research Site

City

Suresnes

ZIP/Postal Code

92150

Country

France

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Toulouse

ZIP/Postal Code

31059

Country

France

Individual Site Status

Recruiting

Facility Name

Research Site

City

Bamberg

ZIP/Postal Code

96049

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Berlin

ZIP/Postal Code

10717

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Berlin

ZIP/Postal Code

12157

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Darmstadt

ZIP/Postal Code

64283

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Frankfurt

ZIP/Postal Code

60596

Country

Germany

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Großhansdorf

ZIP/Postal Code

22927

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Halle

ZIP/Postal Code

6108

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Köln

ZIP/Postal Code

51069

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Marburg

ZIP/Postal Code

35037

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

München-Pasing

ZIP/Postal Code

81241

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

München

ZIP/Postal Code

80336

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Peine

ZIP/Postal Code

31224

Country

Germany

Individual Site Status

Recruiting

Facility Name

Research Site

City

Alexandroupolis

ZIP/Postal Code

68100

Country

Greece

Individual Site Status

Recruiting

Facility Name

Research Site

City

Athens

ZIP/Postal Code

11527

Country

Greece

Individual Site Status

Recruiting

Facility Name

Research Site

City

Exohi Thessaloniki

ZIP/Postal Code

57010

Country

Greece

Individual Site Status

Recruiting

Facility Name

Research Site

City

Ioannina

ZIP/Postal Code

45500

Country

Greece

Individual Site Status

Recruiting

Facility Name

Research Site

City

Patras

ZIP/Postal Code

26500

Country

Greece

Individual Site Status

Recruiting

Facility Name

Research Site

City

Thessaloniki

ZIP/Postal Code

57010

Country

Greece

Individual Site Status

Recruiting

Facility Name

Research Site

City

Ashkelon

ZIP/Postal Code

78278

Country

Israel

Individual Site Status

Recruiting

Facility Name

Research Site

City

Beer Sheva

ZIP/Postal Code

8410101

Country

Israel

Individual Site Status

Recruiting

Facility Name

Research Site

City

Jerusalem

ZIP/Postal Code

91120

Country

Israel

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Jerusalem

ZIP/Postal Code

9372212

Country

Israel

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kfar-Saba

ZIP/Postal Code

4428164

Country

Israel

Individual Site Status

Recruiting

Facility Name

Research Site

City

Rehovot

ZIP/Postal Code

76100

Country

Israel

Individual Site Status

Recruiting

Facility Name

Research Site

City

Tel Aviv

ZIP/Postal Code

6423906

Country

Israel

Individual Site Status

Recruiting

Facility Name

Research Site

City

Bari

ZIP/Postal Code

70124

Country

Italy

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Macerata

ZIP/Postal Code

62100

Country

Italy

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Massa

ZIP/Postal Code

54100

Country

Italy

Individual Site Status

Recruiting

Facility Name

Research Site

City

Messina

ZIP/Postal Code

98124

Country

Italy

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Milano

ZIP/Postal Code

20142

Country

Italy

Individual Site Status

Recruiting

Facility Name

Research Site

City

Milano

ZIP/Postal Code

20157

Country

Italy

Individual Site Status

Recruiting

Facility Name

Research Site

City

Napoli

ZIP/Postal Code

80131

Country

Italy

Individual Site Status

Recruiting

Facility Name

Research Site

City

Roma

ZIP/Postal Code

00168

Country

Italy

Individual Site Status

Recruiting

Facility Name

Research Site

City

Salerno

ZIP/Postal Code

84131

Country

Italy

Individual Site Status

Recruiting

Facility Name

Research Site

City

San Donà di Piave

ZIP/Postal Code

30027

Country

Italy

Individual Site Status

Terminated

Facility Name

Research Site

City

Sassari

ZIP/Postal Code

07100

Country

Italy

Individual Site Status

Recruiting

Facility Name

Research Site

City

Statte

ZIP/Postal Code

74010

Country

Italy

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Telese Terme

ZIP/Postal Code

82037

Country

Italy

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Tradate

ZIP/Postal Code

21049

Country

Italy

Individual Site Status

Recruiting

Facility Name

Research Site

City

Vercelli

ZIP/Postal Code

13100

Country

Italy

Individual Site Status

Recruiting

Facility Name

Research Site

City

Verona

ZIP/Postal Code

37134

Country

Italy

Individual Site Status

Recruiting

Facility Name

Research Site

City

Lima

ZIP/Postal Code

15036

Country

Peru

Individual Site Status

Recruiting

Facility Name

Research Site

City

Lima

ZIP/Postal Code

15046

Country

Peru

Individual Site Status

Recruiting

Facility Name

Research Site

City

Lima

ZIP/Postal Code

15088

Country

Peru

Individual Site Status

Recruiting

Facility Name

Research Site

City

Lima

ZIP/Postal Code

L18

Country

Peru

Individual Site Status

Recruiting

Facility Name

Research Site

City

Lima

ZIP/Postal Code

LIMA 21

Country

Peru

Individual Site Status

Recruiting

Facility Name

Research Site

City

Lima

ZIP/Postal Code

LIMA 31

Country

Peru

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Piura

ZIP/Postal Code

20001

Country

Peru

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Baguio

ZIP/Postal Code

2600

Country

Philippines

Individual Site Status

Recruiting

Facility Name

Research Site

City

Cebu City

ZIP/Postal Code

6000

Country

Philippines

Individual Site Status

Recruiting

Facility Name

Research Site

City

Iloilo City

ZIP/Postal Code

5000

Country

Philippines

Individual Site Status

Recruiting

Facility Name

Research Site

City

Manila

ZIP/Postal Code

1000

Country

Philippines

Individual Site Status

Recruiting

Facility Name

Research Site

City

Białystok

ZIP/Postal Code

15-044

Country

Poland

Individual Site Status

Recruiting

Facility Name

Research Site

City

Białystok

ZIP/Postal Code

15-430

Country

Poland

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Białystok

ZIP/Postal Code

15-704

Country

Poland

Individual Site Status

Suspended

Facility Name

Research Site

City

Bychawa

ZIP/Postal Code

23100

Country

Poland

Individual Site Status

Suspended

Facility Name

Research Site

City

Bydgoszcz

ZIP/Postal Code

85-796

Country

Poland

Individual Site Status

Recruiting

Facility Name

Research Site

City

Gdańsk

ZIP/Postal Code

80-214

Country

Poland

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Grudziądz

ZIP/Postal Code

86-300

Country

Poland

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Katowice

ZIP/Postal Code

40-648

Country

Poland

Individual Site Status

Recruiting

Facility Name

Research Site

City

Krakow

ZIP/Postal Code

30-033

Country

Poland

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kraków

ZIP/Postal Code

31-559

Country

Poland

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Lublin

ZIP/Postal Code

20-412

Country

Poland

Individual Site Status

Recruiting

Facility Name

Research Site

City

Nowa Sól

ZIP/Postal Code

67-100

Country

Poland

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Ostrowiec Świętokrzyski

ZIP/Postal Code

27-400

Country

Poland

Individual Site Status

Recruiting

Facility Name

Research Site

City

Ostróda

ZIP/Postal Code

14-100

Country

Poland

Individual Site Status

Recruiting

Facility Name

Research Site

City

Poznań

ZIP/Postal Code

60-693

Country

Poland

Individual Site Status

Recruiting

Facility Name

Research Site

City

Poznań

ZIP/Postal Code

61-578

Country

Poland

Individual Site Status

Completed

Facility Name

Research Site

City

Poznań

ZIP/Postal Code

61-731

Country

Poland

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Rzeszów

ZIP/Postal Code

35-205

Country

Poland

Individual Site Status

Recruiting

Facility Name

Research Site

City

Skierniewice

ZIP/Postal Code

96-100

Country

Poland

Individual Site Status

Completed

Facility Name

Research Site

City

Sosnowiec

ZIP/Postal Code

41-208

Country

Poland

Individual Site Status

Recruiting

Facility Name

Research Site

City

Warszawa

ZIP/Postal Code

04-141

Country

Poland

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Wołomin

ZIP/Postal Code

05-200

Country

Poland

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Wroclaw

ZIP/Postal Code

54-239

Country

Poland

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Wrocław

ZIP/Postal Code

53-301

Country

Poland

Individual Site Status

Recruiting

Facility Name

Research Site

City

Caguas

ZIP/Postal Code

00726

Country

Puerto Rico

Individual Site Status

Recruiting

Facility Name

Research Site

City

Ponce

ZIP/Postal Code

00717

Country

Puerto Rico

Individual Site Status

Recruiting

Facility Name

Research Site

City

Brasov

ZIP/Postal Code

500283

Country

Romania

Individual Site Status

Recruiting

Facility Name

Research Site

City

Bucharest

ZIP/Postal Code

50159

Country

Romania

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Bucuresti

ZIP/Postal Code

014142

Country

Romania

Individual Site Status

Not yet recruiting

Facility Name

Research Site

City

Cluj-Napoca

ZIP/Postal Code

400371

Country

Romania

Individual Site Status

Recruiting

Facility Name

Research Site

City

Constanta

ZIP/Postal Code

900002

Country

Romania

Individual Site Status

Recruiting

Facility Name

Research Site

City

Iasi

ZIP/Postal Code

700304

Country

Romania

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Timisoara

ZIP/Postal Code

300002

Country

Romania

Individual Site Status

Recruiting

Facility Name

Research Site

City

Chelyabinsk

ZIP/Postal Code

454106

Country

Russian Federation

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Izhevsk

ZIP/Postal Code

426061

Country

Russian Federation

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Moscow

ZIP/Postal Code

105077

Country

Russian Federation

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Moscow

ZIP/Postal Code

107150

Country

Russian Federation

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Novosibirsk

ZIP/Postal Code

630008

Country

Russian Federation

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Penza

ZIP/Postal Code

440067

Country

Russian Federation

Individual Site Status

Terminated

Facility Name

Research Site

City

Perm

ZIP/Postal Code

614000

Country

Russian Federation

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Saint Petersburg

ZIP/Postal Code

194354

Country

Russian Federation

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Saratov

ZIP/Postal Code

410012

Country

Russian Federation

Individual Site Status

Completed

Facility Name

Research Site

City

Tomsk

ZIP/Postal Code

634034

Country

Russian Federation

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Ulyanovsk

ZIP/Postal Code

432009

Country

Russian Federation

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Hsinchu

ZIP/Postal Code

300

Country

Taiwan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kaohsiung

ZIP/Postal Code

807

Country

Taiwan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Kaohsiung

ZIP/Postal Code

82445

Country

Taiwan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Taichung

ZIP/Postal Code

40443

Country

Taiwan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Taichung

ZIP/Postal Code

40705

Country

Taiwan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Taipei

ZIP/Postal Code

100

Country

Taiwan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Taoyuan

ZIP/Postal Code

333

Country

Taiwan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Yunlin

ZIP/Postal Code

640

Country

Taiwan

Individual Site Status

Recruiting

Facility Name

Research Site

City

Bang Kra So

ZIP/Postal Code

11000

Country

Thailand

Individual Site Status

Recruiting

Facility Name

Research Site

City

Bangkok

ZIP/Postal Code

10700

Country

Thailand

Individual Site Status

Active, not recruiting

Facility Name

Research Site

City

Hat Yai

ZIP/Postal Code

90110

Country

Thailand

Individual Site Status

Recruiting

Facility Name

Research Site

City

Khon Kaen

ZIP/Postal Code

40000

Country

Thailand

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Khon Kaen

ZIP/Postal Code

40002

Country

Thailand

Individual Site Status

Recruiting

Facility Name

Research Site

City

Muang,

ZIP/Postal Code

55000

Country

Thailand

Individual Site Status

Recruiting

Facility Name

Research Site

City

Muang

ZIP/Postal Code

22000

Country

Thailand

Individual Site Status

Recruiting

Facility Name

Research Site

City

Mueang

ZIP/Postal Code

20000

Country

Thailand

Individual Site Status

Recruiting

Facility Name

Research Site

City

Nakhon Ratchasima

ZIP/Postal Code

30000

Country

Thailand

Individual Site Status

Recruiting

Facility Name

Research Site

City

Blackpool

ZIP/Postal Code

FY4 3AD

Country

United Kingdom

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Bradford

ZIP/Postal Code

BD9 6RJ

Country

United Kingdom

Individual Site Status

Recruiting

Facility Name

Research Site

City

Corby

ZIP/Postal Code

NN17 2UR

Country

United Kingdom

Individual Site Status

Recruiting

Facility Name

Research Site

City

Corby

ZIP/Postal Code

NN18 9EZ

Country

United Kingdom

Individual Site Status

Recruiting

Facility Name

Research Site

City

Enfield

ZIP/Postal Code

EN3 4GS

Country

United Kingdom

Individual Site Status

Recruiting

Facility Name

Research Site

City

Glasgow

ZIP/Postal Code

G12 0YN

Country

United Kingdom

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Hampshire

ZIP/Postal Code

SO16 6YD

Country

United Kingdom

Individual Site Status

Recruiting

Facility Name

Research Site

City

High Wycombe

ZIP/Postal Code

HP11 2QW

Country

United Kingdom

Individual Site Status

Recruiting

Facility Name

Research Site

City

London

ZIP/Postal Code

NW3 2QG

Country

United Kingdom

Individual Site Status

Withdrawn

Facility Name

Research Site

City

Northwood

ZIP/Postal Code

HA6 2RN

Country

United Kingdom

Individual Site Status

Recruiting

Facility Name

Research Site

City

Preston

ZIP/Postal Code

PR2 9QB

Country

United Kingdom

Individual Site Status

Recruiting

Facility Name

Research Site

City

Shipley

ZIP/Postal Code

BD18 3SA

Country

United Kingdom

Individual Site Status

Recruiting

Facility Name

Research Site

City

Wokingham

ZIP/Postal Code

RG40 1XS

Country

United Kingdom

Individual Site Status

Withdrawn

12. IPD Sharing Statement

Learn more about this trial

Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations.

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Efficacy and Safety of Tozorakimab in Symptomatic Chronic Obstructive Pulmonary Disease With a History of Exacerbations. (TITANIA)

Chronic Obstructive Pulmonary Disease (COPD)

About this trial

Eligibility Criteria

Sites / Locations

Arms of the Study

Arm 1

Arm 2

Arm 3

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

1. Study Identification

2. Study Status

3. Sponsor/Collaborators

4. Oversight

5. Study Description

6. Conditions and Keywords

7. Study Design

8. Arms, Groups, and Interventions

10. Eligibility

12. IPD Sharing Statement

Learn more about this trial