Efficacy and Tolerability of Suprep With and Without Simethicone for Routine Colonoscopy for Colorectal Cancer Screening
Colorectal Cancer
About this trial
This is an interventional screening trial for Colorectal Cancer focused on measuring Suprep, Simethicone, Colorectal cancer screening, Routine colonoscopy, sodium sulfate/potassium sulfate/magnesium sulfate, Bowel cleansing, Mass screening
Eligibility Criteria
Inclusion Criteria:
- Age greater than 18 years
- Outpatients who require elective colonoscopy for colorectal cancer screening at Iowa Endoscopy Center and at University of Florida - Jacksonville
Exclusion Criteria:
- Allergy or hypersensitivity to any constituent of the lavage solution or to simethicone
- Presence of any contraindication to colonoscopy (i.e. uncontrolled congestive heart failure, New York Heart Association classification III-IV, history of myocardial infarction within 6 months, coagulopathy)
- Massive ascites
- Renal insufficiency
- Pregnancy
- History of colonic surgery
- History of anti-flatulence or laxative agent within one week
- Refusal/inability to give consent
- Patients undergoing colonoscopy for reasons other than colorectal cancer screening
- Mentally disabled
- Non-English-speaking patients
Sites / Locations
- UF Health Jacksonville
- Iowa Endoscopy Center
Arms of the Study
Arm 1
Arm 2
Active Comparator
Placebo Comparator
Simethicone Group
Placebo Group
Early in the evening prior to colonoscopy, patients will be instructed to consume one 6 ounce bottle of oral sodium sulfate/potassium sulfate/magnesium sulfate (Suprep) solution (containing sodium sulfate 17.5 grams, potassium sulfate 3.13 grams, and magnesium sulfate 1.6 grams) diluted with 16 ounces of water over one hour. Over the next hour, the patient will be instructed to drink an additional 32 ounces of water. On the day of colonoscopy, the same procedure will be repeated. Patients will take 2.4 mL simethicone in a half glass of water immediately after consuming each dose of the Suprep. All of the bowel preparation solution and required water should be consumed at least 2 hours prior to colonoscopy.
Early in the evening prior to colonoscopy, patients will be instructed to consume one 6 ounce bottle of oral sodium sulfate/potassium sulfate/magnesium sulfate (Suprep) solution (containing sodium sulfate 17.5 grams, potassium sulfate 3.13 grams, and magnesium sulfate 1.6 grams) diluted with 16 ounces of water over one hour. Over the next hour, the patient will be instructed to drink an additional 32 ounces of water. On the day of colonoscopy, the same procedure will be repeated. Patients will take 2.4 mL of placebo (identical in appearance to simethicone) in a half glass of water immediately after consuming each dose of the Suprep. All of the bowel preparation solution and required water should be consumed at least 2 hours prior to colonoscopy.