Efficacy of Azelastine and Mometasone Irrigation in Comparison to Nasal Sprays in Patients With Chronic Rhinitis
Chronic Rhinitis
About this trial
This is an interventional treatment trial for Chronic Rhinitis focused on measuring mometasone, azelastine, irrigation, topical therapy, nasal spray, chronic rhinitis
Eligibility Criteria
Inclusion Criteria: Adults 18 years and older seeking treatment for chronic rhinitis and willing to undergo six months of topical therapy. Diagnosis of Chronic Rhinitis. Exclusion Criteria: The patient has diagnosis(es) other than chronic rhinitis that can account for his/her symptoms (septal deviation, nasal valve collapse, chronic sinusitis). Use of oral antihistamines or oral steroids, unless patient undergoes a 4 week washout period. Smokers (tobacco, marijuana, vaping, etc.). Known or suspected pregnancy, or lactation. Other medical conditions that the investigator believed would confound the study. Allergy to study drugs.
Sites / Locations
- Northshore University HealthSystemRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Experimental
Experimental
Azelastine and Mometasone Nasal Spray
Mometasone Nasal Irrigation
Azelastine and Mometasone Nasal Irrigation
The study intervention will be saline irrigation (240 mL) followed by azelastine spray (137 mcg/spray) and mometasone spray (50 mcg/spray). Participants will have to dissolve the salt packet in a 240 mL sinus rinse bottle to create the saline solution. All participants will be instructed to perform the following twice a day: irrigation of right and left nasal cavity with half of the saline solution for each side followed by 2 sprays per nostril of both of the nasal sprays.
The study intervention will be mometasone (1 mg/capsule). Participants will be required to dissolve the contents of the capsule into a 240 mL sinus rinse bottle along with the salt packet to create the rinse solution. All participants will be instructed to perform the following twice a day: irrigation of right and left nasal cavity with half of the rinse solution for each side.
The study intervention will be azelastine (1mg) and mometasone (1 mg). The azelastine and mometasone will be provided in one capsule identical to the mometasone capsule. Participants will be required to dissolve the contents of the capsule into a 240 mL sinus rinse bottle along with the salt packet to create the rinse solution. All participants will be instructed to perform the following twice a day: irrigation of right and left nasal cavity with half of the rinse solution for each side.