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Efficacy of Methylsulfonylmethane Supplementation on Osteoarthritis of The Knee: A Randomized Controlled Study

Primary Purpose

Knee Osteoarthritis

Status
Completed
Phase
Not Applicable
Locations
Study Type
Interventional
Intervention
Methylsulfonylmethane (MSM)
Sponsored by
Assaf-Harofeh Medical Center
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional trial for Knee Osteoarthritis

Eligibility Criteria

40 Years - 70 Years (Adult, Older Adult)All Sexes

Inclusion Criteria:

  • symptomatic knee OA for at least 6 months according to the clinical criteria of the American College of Rheumatology (ACR)
  • radiographic confirmed knee OA according to the Kellgren & Lawrence scale

Exclusion Criteria:

  • acute septic arthritis
  • inflammatory arthritis
  • any other type of arthritis
  • history of knee buckling or recent knee injury
  • lack of physical or mental bility to perform or comply with the treatment procedure
  • diabetes mellitus
  • fibromyalgia or other chronic pain syndromes
  • concurrent anti-coagulant/anti-platelet drugs
  • arthroscopy or intra-articular injections in the previous 3 months

Sites / Locations

    Arms of the Study

    Arm 1

    Arm Type

    Experimental

    Arm Label

    Purified MSM

    Arm Description

    Outcomes

    Primary Outcome Measures

    WOMAC questionnaire

    Secondary Outcome Measures

    Full Information

    First Posted
    August 21, 2010
    Last Updated
    August 24, 2010
    Sponsor
    Assaf-Harofeh Medical Center
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    1. Study Identification

    Unique Protocol Identification Number
    NCT01188213
    Brief Title
    Efficacy of Methylsulfonylmethane Supplementation on Osteoarthritis of The Knee: A Randomized Controlled Study
    Study Type
    Interventional

    2. Study Status

    Record Verification Date
    May 2005
    Overall Recruitment Status
    Completed
    Study Start Date
    undefined (undefined)
    Primary Completion Date
    undefined (undefined)
    Study Completion Date
    undefined (undefined)

    3. Sponsor/Collaborators

    Name of the Sponsor
    Assaf-Harofeh Medical Center

    4. Oversight

    Data Monitoring Committee
    No

    5. Study Description

    Brief Summary
    The aim of this study was to determine the efficacy of methylsulfonylmethane (MSM) in treating patients with knee OA.

    6. Conditions and Keywords

    Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
    Knee Osteoarthritis

    7. Study Design

    Study Phase
    Not Applicable

    8. Arms, Groups, and Interventions

    Arm Title
    Purified MSM
    Arm Type
    Experimental
    Intervention Type
    Dietary Supplement
    Intervention Name(s)
    Methylsulfonylmethane (MSM)
    Primary Outcome Measure Information:
    Title
    WOMAC questionnaire

    10. Eligibility

    Sex
    All
    Minimum Age & Unit of Time
    40 Years
    Maximum Age & Unit of Time
    70 Years
    Eligibility Criteria
    Inclusion Criteria: symptomatic knee OA for at least 6 months according to the clinical criteria of the American College of Rheumatology (ACR) radiographic confirmed knee OA according to the Kellgren & Lawrence scale Exclusion Criteria: acute septic arthritis inflammatory arthritis any other type of arthritis history of knee buckling or recent knee injury lack of physical or mental bility to perform or comply with the treatment procedure diabetes mellitus fibromyalgia or other chronic pain syndromes concurrent anti-coagulant/anti-platelet drugs arthroscopy or intra-articular injections in the previous 3 months

    12. IPD Sharing Statement

    Citations:
    PubMed Identifier
    21708034
    Citation
    Debbi EM, Agar G, Fichman G, Ziv YB, Kardosh R, Halperin N, Elbaz A, Beer Y, Debi R. Efficacy of methylsulfonylmethane supplementation on osteoarthritis of the knee: a randomized controlled study. BMC Complement Altern Med. 2011 Jun 27;11:50. doi: 10.1186/1472-6882-11-50.
    Results Reference
    derived

    Learn more about this trial

    Efficacy of Methylsulfonylmethane Supplementation on Osteoarthritis of The Knee: A Randomized Controlled Study

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