Efficacy of Paste Type Acellular Dermal Matrix(CG Paste) in Chronic Wound Healing
Chronic Wound
About this trial
This is an interventional treatment trial for Chronic Wound focused on measuring ADM, acellular dermal matrix
Eligibility Criteria
Inclusion Criteria:
- Adults over 19 years
- Patients with skin defect from full-thickness skin defect to bone exposure level after debridement of wound
- Chronic wounds that have not been healed despite adequate treatment for more than 3 weeks after wounding
- At the time of the study, patients with a wound size of 4 cm 2 or more
Exclusion Criteria:
- Patients with superficial or partial thickness skin defect
- osteomyelitis patient
- An undermining wound, tunneling wound, which can not measure the exact depth, can be used if the wound is open wound due to debridement of wound.
- Patients who exceeded 12% of HbA1c within 3 months before participating in the study
- Patients with serum creatinine concentration of 3.0 mg / dL or more within 30 days before the study
- Patients who have applied other medical devices and growth factors for wound healing within 30 days before participating in the study
- Patients with lesion infections (available after infection treatment)
Sites / Locations
- Seoul National University HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
CG Paste+EasyFoam
EasyFoam
The subjects assigned to the test group through random assignment will receive the wound treatment by applying CG Paste and EasyFoam. CG Paste is a medical device currently marketed in CGBio.It is a free-flowing, acellular allogeneic dermis processed from human tissue skin, and then granulated and homogenized. This increases the water content and viscosity of the micronized ADM particles mixed with the gelatin sol carrier to protect the wound area and maintain the wet environment by applying to the desired wound area.It contains collagen, elastin and various growth factors in the dermis and has excellent tissue compatibility compared to the heterogeneous or synthetic material, so that the immune rejection is hardly observed in the graft site. It also contains collagen, elastin, fibronectin, laminin, and proteoglycans, which are components of the human skin, to help the interaction between normal cells and extracellular matrix.
Subjects randomly assigned to the control group receive EasyFoam treatment for wound healing. The foam has excellent moisture permeability, absorbs a large amount of exudates, and prevents scar formation to minimize scar formation.