Efficacy of Pegylated Interferon on Liver Fibrosis in Co-infected Patient With HIV and Hepatitis C

Inclusion Criteria: HIV infection (Western Blot +) C hepatitis (RNA viral hepatitis C [VHC] +) Chronic active C hepatitis on liver histological score METAVIR (A over or equal to 1 and F over or equal to 2) on biopsy performed at least 18 months before the expected date of inclusion Previous treatment for C hepatitis for at least 3 months including peg-interferon and ribavirin or peg-interferon alone if counterindication for ribavirin occurred Failure to eradicate C hepatitis virus after well conducted treatment The liver biopsy should have been realised at least 18 months before inclusion : Either before treatment for C hepatitis in patients treated at most 7 months Or at least 6 months after anti HCV treatment in patient treated for more than 7 months (wash out period) Regular follow up in an outpatient clinic for HIV Unchanged antiretroviral treatment the last 3 months before inclusion Inform consent Exclusion Criteria: History of transplantation or clinical hepatic failure Opportunistic infection in the past three months before inclusion Any hepatic disease not related to HCV (B hepatitis, hemochromatosis, Wilson disease) Diabetes mellitus Immunocompromised treatment Active intravenous drug addiction Alcohol consumption of more than 50 g per day Counterindication for the use of interferon