Efficacy of Preconditioned Adipose-Derived Stem Cells in Fat Grafting
Romberg Disease, Craniofacial Microsomia, Burn Scar
About this trial
This is an interventional treatment trial for Romberg Disease focused on measuring Facial deformities, Fat grafting, Adipose derived stem cells, Preconditioning
Eligibility Criteria
Inclusion criteria Age 18-50 years (male or female) Body-mass index 20-30 kg/m² Suitable for liposuction as assessed by the expected cosmetic results Provided signed informed consent Exclusion criteria Systemic disorders include autoimmune diseases, hemorrhagic diseases, bone marrow aplasia, sepsis, cancer, and others Local disorders include acne, infections and others Risk factors include smoking, uncompensated diabetes, hypertension, and allergy to the drugs used for general anesthesia Microbiological contamination of either the cell culture or the transplanted tissue
Sites / Locations
- Stem Cell Laboratory, Jinnah Burn and Reconstructive Surgery Center (JB&RSC)Recruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Active Comparator
Cultured ASCs enrichment fat grafting
Curcumin-preconditioned ASCs enrichment fat grafting
conventional fat grafting
Fat graft will be supplemented with naïve ASCs
Fat graft will be augmented with curcumin preconditioned ASCs
Fat graft will not be supplemented with ex-vivo expanded ASCs