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Efficacy, Safety, and Tolerability of Eluxadoline in the Treatment of Participants With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-d)

Primary Purpose

Irritable Bowel Syndrome

Status

Completed

Phase

Phase 3

Locations

International

Study Type

Interventional

Intervention

Eluxadoline

Placebo

About this trial

This is an interventional treatment trial for Irritable Bowel Syndrome focused on measuring Irritable bowel syndrome with diarrhea, Irritable bowel syndrome, Diarrhea predominant irritable bowel syndrome, Colonic diseases, Colonic diseases, functional, Digestive system disease, Gastrointestinal disease, Intestinal disease, Colonic pseudo-obstruction, Diarrhea, Signs and symptoms, Digestive

Eligibility Criteria

18 Years - 80 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

Participant is 18 to 80 years old
Participant has a diagnosis of irritable bowel syndrome (IBS) with a subtype of diarrhea defined by the Rome III criteria.

2. Participant has had a colonoscopy performed:

Within 10 years prior to Prescreening if participant is at least 50 years of age (sigmoidoscopy, double contrast barium enema, or computed tomography (CT) colonography within the past 5 years is acceptable)
Since the onset (if applicable) of any of the following alarm features for participants of any age
- Participant has documented weight loss within the past 6 months
- Participant has nocturnal symptoms
- Participant has a familial history of first-degree relatives with colon cancer
- Participant has blood mixed with their stool (excluding blood from hemorrhoids).
  3. Female participants must be:
Postmenopausal, defined as 52 years or older and amenorrheic for at least 2 years at Prescreening,
Surgically sterile (have had a hysterectomy or bilateral oophorectomy, tubal ligation, or otherwise be incapable of pregnancy),
Abstinent, or
If sexually active, be practicing an effective method of birth control.

Exclusion Criteria:

Participant has a diagnosis of IBS with a subtype of constipation, mixed IBS, or unsubtyped IBS by the Rome III criteria.
Participant has a history of inflammatory or immune-mediated gastrointestinal (GI) disorders including inflammatory bowel disease (ie, Crohn's disease, ulcerative colitis) and celiac disease.
Participant has a history of diverticulitis within 3 months prior to Prescreening.
Participant has a history of intestinal obstruction, stricture, toxic megacolon, GI perforation, fecal impaction, gastric banding, bariatric surgery, adhesions, ischemic colitis, or impaired intestinal circulation (eg, aortoiliac disease).
Participant has any of the following surgical history:
- Cholecystectomy with any history of post cholecystectomy biliary tract pain
- Any abdominal surgery within the 3 months prior to Prescreening
- Participant has a history of major gastric, hepatic, pancreatic, or intestinal surgery (appendectomy, hemorrhoidectomy, or polypectomy greater than 3 months post surgery are allowed)

Other protocol-specific eligibility criteria may apply.

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm Type

Experimental

Placebo Comparator

Arm Label

Eluxadoline 75 mg

Eluxadoline 100 mg

Placebo

Arm Description

Eluxadoline 75 mg tablets, orally, twice daily for up to 26 weeks period.

Eluxadoline 100 mg tablets, orally, twice daily for up to 26 weeks period.

Eluxadoline placebo matching tablets, orally, twice daily for up to 26 weeks period.

Outcomes

Primary Outcome Measures

Percentage of Participants Who Were Composite Responders Based on Improvements From Baseline in Daily Worst Abdominal Pain and Daily Stool Consistency Scores

Composite responders were defined as participants who met the daily response criteria for at least 50% of the days with diary entries during the interval of interest. A participant must had met both of the following criteria on a given day to be a daily responder: 1) Daily pain response: worst abdominal pain scores in the past 24 hours improved by ≥30% compared to baseline (average of daily worst abdominal pain the week prior to randomization). 2) Daily stool consistency response: Bristol Stool Scale (BSS) score <5 (ie, score of 1, 2, 3, or 4) or the absence of a bowel movement if accompanied by ≥30% improvement in worst abdominal pain compared to baseline pain. Bristol stool scale was defined as 7-point Scale in which a score of 1 = separate hard lumps, 2 = sausage shaped but lumpy, 3 = sausage-like with cracks on the surface, 4 = sausage-like but smooth and soft, 5 = soft blobs with clear cut edges, 6 = fluffy pieces with ragged edges, and 7 = watery with no solid pieces.

Secondary Outcome Measures

Percentage of Participants Who Were Composite Responders Based on Improvements From Baseline in Daily Worst Abdominal Pain and Daily Stool Consistency Scores

Percentage of Participants Who Were Pain Responders In Daily Worst Abdominal Pain Scores by Intervals

Pain responders were defined as participants who met the daily pain response criteria (ie, the worst abdominal pain score in the past 24 hours improved by ≥30% compared to baseline) for at least 50% of days with diary entries during each interval. A participant must have had a minimum of 20 days of diary entries over any 4-week interval, a minimum of 60 days of diary entries over the 12-week interval, and a minimum of 110 days of diary entries over the 26-week interval to be a responder.

Percentage of Participants Who Were Responders In Daily Stool Consistency Scores by Intervals

Stool consistency responders: Participants who met daily stool consistency response criterion (ie,score of 1, 2, 3, or 4 or absence of bowel movement if accompanied by ≥30% improvement in worst abdominal pain compared to baseline pain) for at least 50% of days with diary entries during each interval. BSS was defined as 7-point Scale in which score of 1= separate hard lumps, 2= sausage shaped but lumpy, 3= sausage-like with cracks on the surface, 4= sausage-like but smooth and soft, 5= soft blobs with clear cut edges, 6= fluffy pieces with ragged edges, and 7= watery with no solid pieces. A participant must have had a minimum of 20 days of diary entries over any 4-week interval, a minimum of 60 days of diary entries over 12-week interval, and a minimum of 110 days of diary entries over 26-week interval to be a responder.

Percentage of Participants Who Were Responders In Irritable Bowel Syndrome, Diarrhea Predominant (IBS-d) Global Symptom Scale by Intervals

IBS-d global symptom responders were defined as those participants who met the daily IBS-d global symptom response criteria (ie, IBS-d global symptom score of 0 [none] or 1 [mild]; or a daily IBS-d global symptom score improved by ≥2.0 compared to the baseline average) for at least 50% of days with diary entries during each interval. IBS-d Global Symptom Scale was a 5-point scale, score ranging from 0 to 4. 0= no symptoms, 1= mild symptoms, 2= moderate symptoms, 3= severe symptoms and 4 = very severe symptoms. A participant must have had a minimum of 20 days of diary entries over any 4-week interval, a minimum of 60 days of diary entries over the 12-week interval, and a minimum of 110 days of diary entries over the 26-week interval to be a responder.

Percentage of Participants Who Were Responders to the Irritable Bowel Syndrome Quality of Life Measure (IBS-QoL) Scale

IBS-QoL responders were defined as participants who achieved at least a 14-point improvement in IBS-QoL total score from baseline to the applicable visit. The IBS-QoL consists of 34 items each with a 5-point response scale, where 1 generally represents better responses on items and 5 represents worse responses. The individual responses to the answered items were summed and standardized for a total score and then transformed to a 0- to 100-point (0= worst; 100=better) scale for ease of interpretation.

Percentage of Participants With Irritable Bowel Syndrome - Adequate Relief (IBS-AR) Scale

Adequate relief of IBS symptoms was assessed once weekly by participants answering the IBS-AR item in the electronic diary. IBS-AR responders were defined as participants with a weekly response of "Yes" to adequate relief of their IBS symptoms for at least 50% of the total weeks during the interval. A participant must have had a positive response on ≥6 weeks for the 12-week interval and ≥13 weeks for the 26-week interval, regardless of diary compliance, to be a responder.

Change From Baseline in Daily Abdominal Discomfort Scores

Symptoms of abdominal discomfort were recorded on a 0 to 10 scale, where 0 corresponded to no discomfort and 10 corresponded to worst imaginable discomfort. A negative change from Baseline indicates the discomfort decreased.

Change From Baseline in Daily Abdominal Bloating Scores

Symptoms of abdominal bloating were recorded on a 0 to 10 scale, where 0 corresponded to no bloating and 10 corresponded to worst imaginable bloating. A negative change from Baseline indicates the bloating decreased.

Number of Bowel Movements Per Day

Participants recorded the number of bowel movements over 24 hours daily throughout the treatment.

Number of Bowel Incontinence Episodes

Participants recorded the number of incontinence episodes over 24 hours daily throughout the treatment.

Number of Bowel Incontinence Free Days

An incontinence free day was one where the participant reports zero incontinence episodes. The number of incontinence free days for a participant was assessed each week based on the number of reported days.

Number of Urgency Episodes Per Day

Participants recorded the number of urgency episodes over 24 hours daily throughout the treatment.

Change From Baseline in IBS-QoL Total Scores

The IBS-QoL consists of 34 items each with a 5-point response scale, where 1 generally represents better responses on items and 5 represents worse responses. The individual responses to the answered items were summed and standardized for a total score and then transformed to a 0- to 100- point scale (0=worst; 100=better) for ease of interpretation. A positive change from Baseline indicates that quality of life improved.

Full Information

NCT ID

NCT01553747

First Posted

March 8, 2012

Last Updated

July 27, 2018

Sponsor

Furiex Pharmaceuticals, Inc

1. Study Identification

Unique Protocol Identification Number

NCT01553747

Brief Title

Efficacy, Safety, and Tolerability of Eluxadoline in the Treatment of Participants With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-d)

Official Title

A Randomized, Double-blind, Placebo-controlled, Phase 3 Study to Evaluate the Efficacy, Safety, and Tolerability of JNJ-27018966 in the Treatment of Patients With Diarrhea-Predominant Irritable Bowel Syndrome

Study Type

Interventional

2. Study Status

Record Verification Date

July 2018

Overall Recruitment Status

Completed

Study Start Date

May 29, 2012 (Actual)

Primary Completion Date

January 9, 2014 (Actual)

Study Completion Date

January 9, 2014 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

Furiex Pharmaceuticals, Inc

4. Oversight

Data Monitoring Committee

5. Study Description

Brief Summary

The purpose of this study is to determine the efficacy, safety, and tolerability of different doses of eluxadoline (JNJ-27018966) compared with placebo in the treatment of participants with diarrhea-predominant irritable bowel syndrome.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Irritable Bowel Syndrome

Keywords

Irritable bowel syndrome with diarrhea, Irritable bowel syndrome, Diarrhea predominant irritable bowel syndrome, Colonic diseases, Colonic diseases, functional, Digestive system disease, Gastrointestinal disease, Intestinal disease, Colonic pseudo-obstruction, Diarrhea, Signs and symptoms, Digestive

7. Study Design

Primary Purpose

Treatment

Study Phase

Phase 3

Interventional Study Model

Parallel Assignment

Masking

ParticipantCare ProviderInvestigator

Allocation

Randomized

Enrollment

1146 (Actual)

8. Arms, Groups, and Interventions

Arm Title

Eluxadoline 75 mg

Arm Type

Experimental

Arm Description

Eluxadoline 75 mg tablets, orally, twice daily for up to 26 weeks period.

Arm Title

Eluxadoline 100 mg

Arm Type

Experimental

Arm Description

Eluxadoline 100 mg tablets, orally, twice daily for up to 26 weeks period.

Arm Title

Placebo

Arm Type

Placebo Comparator

Arm Description

Eluxadoline placebo matching tablets, orally, twice daily for up to 26 weeks period.

Intervention Type

Drug

Intervention Name(s)

Eluxadoline

Other Intervention Name(s)

JNJ-27018966

Intervention Description

Oral tablets twice daily

Intervention Type

Drug

Intervention Name(s)

Placebo

Intervention Description

Oral tablets twice daily

Primary Outcome Measure Information:

Title

Percentage of Participants Who Were Composite Responders Based on Improvements From Baseline in Daily Worst Abdominal Pain and Daily Stool Consistency Scores

Description

Time Frame

Up to 12 weeks

Secondary Outcome Measure Information:

Title

Percentage of Participants Who Were Composite Responders Based on Improvements From Baseline in Daily Worst Abdominal Pain and Daily Stool Consistency Scores

Description

Time Frame

Up to 26 weeks

Title

Percentage of Participants Who Were Pain Responders In Daily Worst Abdominal Pain Scores by Intervals

Description

Time Frame

12-week interval (Weeks 1-12), 26-week interval (Weeks 1-26), and 4-week interval (Weeks 1-4, 5-8, 9-12, 13-16, 17-20, and 21-24)

Title

Percentage of Participants Who Were Responders In Daily Stool Consistency Scores by Intervals

Description

Time Frame

12-week interval (Weeks 1-12), 26-week interval (Weeks 1-26), and 4-week interval (Weeks 1-4, 5-8, 9-12, 13-16, 17-20, and 21-24)

Title

Percentage of Participants Who Were Responders In Irritable Bowel Syndrome, Diarrhea Predominant (IBS-d) Global Symptom Scale by Intervals

Description

Time Frame

12-week interval (Weeks 1-12), 26-week interval (Weeks 1-26), and 4-week interval (Weeks 1-4, 5-8, 9-12, 13-16, 17-20, and 21-24)

Title

Percentage of Participants Who Were Responders to the Irritable Bowel Syndrome Quality of Life Measure (IBS-QoL) Scale

Description

Time Frame

Weeks 4, 8, 12, 18, 26 and 30 (End of Treatment [EOT])

Title

Percentage of Participants With Irritable Bowel Syndrome - Adequate Relief (IBS-AR) Scale

Description

Time Frame

12-week interval (Weeks 1-12) and 26-week interval (Weeks 1-26)

Title

Change From Baseline in Daily Abdominal Discomfort Scores

Description

Time Frame

Baseline, Weeks 4, 12 and 26

Title

Change From Baseline in Daily Abdominal Bloating Scores

Description

Time Frame

Baseline, Weeks 4, 12 and 26

Title

Number of Bowel Movements Per Day

Description

Participants recorded the number of bowel movements over 24 hours daily throughout the treatment.

Time Frame

Weeks 4, 12 and 26

Title

Number of Bowel Incontinence Episodes

Description

Participants recorded the number of incontinence episodes over 24 hours daily throughout the treatment.

Time Frame

Weeks 4, 12 and 26

Title

Number of Bowel Incontinence Free Days

Description

Time Frame

Weeks 4, 12 and 26

Title

Number of Urgency Episodes Per Day

Description

Participants recorded the number of urgency episodes over 24 hours daily throughout the treatment.

Time Frame

Weeks 4, 12 and 26

Title

Change From Baseline in IBS-QoL Total Scores

Description

Time Frame

Baseline, Weeks 4, 8, 12, 18, 26 and 30/EOT

10. Eligibility

Sex

All

Minimum Age & Unit of Time

18 Years

Maximum Age & Unit of Time

80 Years

Accepts Healthy Volunteers

Eligibility Criteria

Inclusion Criteria: Participant is 18 to 80 years old Participant has a diagnosis of irritable bowel syndrome (IBS) with a subtype of diarrhea defined by the Rome III criteria. 2. Participant has had a colonoscopy performed: Within 10 years prior to Prescreening if participant is at least 50 years of age (sigmoidoscopy, double contrast barium enema, or computed tomography (CT) colonography within the past 5 years is acceptable) Since the onset (if applicable) of any of the following alarm features for participants of any age Participant has documented weight loss within the past 6 months Participant has nocturnal symptoms Participant has a familial history of first-degree relatives with colon cancer Participant has blood mixed with their stool (excluding blood from hemorrhoids). 3. Female participants must be: Postmenopausal, defined as 52 years or older and amenorrheic for at least 2 years at Prescreening, Surgically sterile (have had a hysterectomy or bilateral oophorectomy, tubal ligation, or otherwise be incapable of pregnancy), Abstinent, or If sexually active, be practicing an effective method of birth control. Exclusion Criteria: Participant has a diagnosis of IBS with a subtype of constipation, mixed IBS, or unsubtyped IBS by the Rome III criteria. Participant has a history of inflammatory or immune-mediated gastrointestinal (GI) disorders including inflammatory bowel disease (ie, Crohn's disease, ulcerative colitis) and celiac disease. Participant has a history of diverticulitis within 3 months prior to Prescreening. Participant has a history of intestinal obstruction, stricture, toxic megacolon, GI perforation, fecal impaction, gastric banding, bariatric surgery, adhesions, ischemic colitis, or impaired intestinal circulation (eg, aortoiliac disease). Participant has any of the following surgical history: Cholecystectomy with any history of post cholecystectomy biliary tract pain Any abdominal surgery within the 3 months prior to Prescreening Participant has a history of major gastric, hepatic, pancreatic, or intestinal surgery (appendectomy, hemorrhoidectomy, or polypectomy greater than 3 months post surgery are allowed) Other protocol-specific eligibility criteria may apply.

Facility Information:

Facility Name

Furiex Research Site

City

Birmingham

State/Province

Alabama

ZIP/Postal Code

35209

Country

United States

Facility Name

Furiex Research Site

City

Birmingham

State/Province

Alabama

ZIP/Postal Code

35242

Country

United States

Facility Name

Furiex Research Site

City

Decatur

State/Province

Alabama

ZIP/Postal Code

35603

Country

United States

Facility Name

Furiex Research Site

City

Huntsville

State/Province

Alabama

ZIP/Postal Code

35801

Country

United States

Facility Name

Furiex Research Site

City

Mobile

State/Province

Alabama

ZIP/Postal Code

36608

Country

United States

Facility Name

Furiex Research Site

City

Montgomery

State/Province

Alabama

ZIP/Postal Code

36109

Country

United States

Facility Name

Furiex Research Site

City

Sheffield

State/Province

Alabama

ZIP/Postal Code

35660

Country

United States

Facility Name

Furiex Research Site

City

Tuscaloosa

State/Province

Alabama

ZIP/Postal Code

35401

Country

United States

Facility Name

Furiex Research Site

City

Glendale

State/Province

Arizona

ZIP/Postal Code

85306

Country

United States

Facility Name

Furiex Research Site

City

Glendale

State/Province

Arizona

ZIP/Postal Code

85308

Country

United States

Facility Name

Furiex Research Site

City

Mesa

State/Province

Arizona

ZIP/Postal Code

85206

Country

United States

Facility Name

Furiex Research Site

City

Phoenix

State/Province

Arizona

ZIP/Postal Code

85023

Country

United States

Facility Name

Furiex Research Site

City

Phoenix

State/Province

Arizona

ZIP/Postal Code

85032

Country

United States

Facility Name

Furiex Research Site

City

Tucson

State/Province

Arizona

ZIP/Postal Code

85704

Country

United States

Facility Name

Furiex Research Site

City

Tucson

State/Province

Arizona

ZIP/Postal Code

85712

Country

United States

Facility Name

Furiex Research Site

City

Jonesboro

State/Province

Arkansas

ZIP/Postal Code

72401

Country

United States

Facility Name

Furiex Research Site

City

Little Rock

State/Province

Arkansas

ZIP/Postal Code

72205

Country

United States

Facility Name

Furiex Research Site

City

Sherwood

State/Province

Arkansas

ZIP/Postal Code

72120

Country

United States

Facility Name

Furiex Research Site

City

Anaheim

State/Province

California

ZIP/Postal Code

92801

Country

United States

Facility Name

Furiex Research Site

City

Chula Vista

State/Province

California

ZIP/Postal Code

91910

Country

United States

Facility Name

Furiex Research Site

City

Encinitas

State/Province

California

ZIP/Postal Code

92024

Country

United States

Facility Name

Furiex Research Site

City

Garden Grove

State/Province

California

ZIP/Postal Code

92840

Country

United States

Facility Name

Furiex Research Site

City

Huntington Beach

State/Province

California

ZIP/Postal Code

92647

Country

United States

Facility Name

Furiex Research Site

City

Irvine

State/Province

California

ZIP/Postal Code

92604

Country

United States

Facility Name

Furiex Research Site

City

La Mesa

State/Province

California

ZIP/Postal Code

91942

Country

United States

Facility Name

Furiex Research Site

City

La Mirada

State/Province

California

ZIP/Postal Code

90638

Country

United States

Facility Name

Furiex Research Site

City

Laguna Hills

State/Province

California

ZIP/Postal Code

92653

Country

United States

Facility Name

Furiex Research Site

City

Lakewood

State/Province

California

ZIP/Postal Code

90805

Country

United States

Facility Name

Furiex Research Site

City

Lincoln

State/Province

California

ZIP/Postal Code

95648

Country

United States

Facility Name

Furiex Research Site

City

Loma Linda

State/Province

California

ZIP/Postal Code

92354

Country

United States

Facility Name

Furiex Research Site

City

Lomita

State/Province

California

ZIP/Postal Code

90717

Country

United States

Facility Name

Furiex Research Site

City

Long Beach

State/Province

California

ZIP/Postal Code

90806

Country

United States

Facility Name

Furiex Research Site

City

Los Angeles

State/Province

California

ZIP/Postal Code

90045

Country

United States

Facility Name

Furiex Research Site

City

Newport Beach

State/Province

California

ZIP/Postal Code

92663

Country

United States

Facility Name

Furiex Research Site

City

North Hollywood

State/Province

California

ZIP/Postal Code

91606

Country

United States

Facility Name

Furiex Research Site

City

Northridge

State/Province

California

ZIP/Postal Code

91325

Country

United States

Facility Name

Furiex Research Site

City

Pasadena

State/Province

California

ZIP/Postal Code

91105

Country

United States

Facility Name

Furiex Research Site

City

Sacramento

State/Province

California

ZIP/Postal Code

95817

Country

United States

Facility Name

Furiex Research Site

City

San Diego

State/Province

California

ZIP/Postal Code

92103

Country

United States

Facility Name

Furiex Research Site

City

San Diego

State/Province

California

ZIP/Postal Code

92105

Country

United States

Facility Name

Furiex Research Site

City

Santa Ana

State/Province

California

ZIP/Postal Code

92701

Country

United States

Facility Name

Furiex Research Site

City

Ventura

State/Province

California

ZIP/Postal Code

93003

Country

United States

Facility Name

Furiex Research Site

City

Walnut Creek

State/Province

California

ZIP/Postal Code

94598

Country

United States

Facility Name

Furiex Research Site

City

Denver

State/Province

Colorado

ZIP/Postal Code

80211

Country

United States

Facility Name

Furiex Research Site

City

Denver

State/Province

Colorado

ZIP/Postal Code

80246

Country

United States

Facility Name

Furiex Research Site

City

Boca Raton

State/Province

Florida

ZIP/Postal Code

33428

Country

United States

Facility Name

Furiex Research Site

City

Boynton Beach

State/Province

Florida

ZIP/Postal Code

33426

Country

United States

Facility Name

Furiex Research Site

City

Bradenton

State/Province

Florida

ZIP/Postal Code

34208

Country

United States

Facility Name

Furiex Research Site

City

Brooksville

State/Province

Florida

ZIP/Postal Code

34601

Country

United States

Facility Name

Furiex Research Site

City

Clearwater

State/Province

Florida

ZIP/Postal Code

33759

Country

United States

Facility Name

Furiex Research Site

City

Cooper City

State/Province

Florida

ZIP/Postal Code

33024

Country

United States

Facility Name

Furiex Research Site

City

Coral Springs

State/Province

Florida

ZIP/Postal Code

33065

Country

United States

Facility Name

Furiex Research Site

City

Eustis

State/Province

Florida

ZIP/Postal Code

32726

Country

United States

Facility Name

Furiex Research Site

City

Fort Lauderdale

State/Province

Florida

ZIP/Postal Code

33308

Country

United States

Facility Name

Furiex Research Site

City

Hallandale Beach

State/Province

Florida

ZIP/Postal Code

33009

Country

United States

Facility Name

Furiex Research Site

City

Hialeah

State/Province

Florida

ZIP/Postal Code

33016

Country

United States

Facility Name

Furiex Research Site

City

Jacksonville

State/Province

Florida

ZIP/Postal Code

32205

Country

United States

Facility Name

Furiex Research Site

City

Jupiter

State/Province

Florida

ZIP/Postal Code

33458

Country

United States

Facility Name

Furiex Research Site

City

Lauderdale Lakes

State/Province

Florida

ZIP/Postal Code

33319

Country

United States

Facility Name

Furiex Research Site

City

Melbourne

State/Province

Florida

ZIP/Postal Code

32901

Country

United States

Facility Name

Furiex Research Site

City

Miami

State/Province

Florida

ZIP/Postal Code

33015

Country

United States

Facility Name

Furiex Research Site

City

Miami

State/Province

Florida

ZIP/Postal Code

33125

Country

United States

Facility Name

Furiex Research Site

City

Miami

State/Province

Florida

ZIP/Postal Code

33126

Country

United States

Facility Name

Furiex Research Site

City

Miami

State/Province

Florida

ZIP/Postal Code

33133

Country

United States

Facility Name

Furiex Research Site

City

Miami

State/Province

Florida

ZIP/Postal Code

33135

Country

United States

Facility Name

Furiex Research Site

City

Miami

State/Province

Florida

ZIP/Postal Code

33144

Country

United States

Facility Name

Furiex Research Site

City

Miami

State/Province

Florida

ZIP/Postal Code

33155

Country

United States

Facility Name

Furiex Research Site

City

Miami

State/Province

Florida

ZIP/Postal Code

33183

Country

United States

Facility Name

Furiex Research Site

City

Miramar

State/Province

Florida

ZIP/Postal Code

33025

Country

United States

Facility Name

Furiex Research Site

City

New Port Richey

State/Province

Florida

ZIP/Postal Code

34652

Country

United States

Facility Name

Furiex Research Site

City

Orlando

State/Province

Florida

ZIP/Postal Code

32806

Country

United States

Facility Name

Furiex Research Site

City

Plant City

State/Province

Florida

ZIP/Postal Code

33563

Country

United States

Facility Name

Furiex Research Site

City

Port Orange

State/Province

Florida

ZIP/Postal Code

32127

Country

United States

Facility Name

Furiex Research Site

City

Saint Petersburg

State/Province

Florida

ZIP/Postal Code

33705

Country

United States

Facility Name

Furiex Research Site

City

Saint Petersburg

State/Province

Florida

ZIP/Postal Code

33709

Country

United States

Facility Name

Furiex Research Site

City

South Miami

State/Province

Florida

ZIP/Postal Code

33143

Country

United States

Facility Name

Furiex Research Site

City

Tampa

State/Province

Florida

ZIP/Postal Code

33607

Country

United States

Facility Name

Furiex Research Site

City

Wellington

State/Province

Florida

ZIP/Postal Code

33414

Country

United States

Facility Name

Furiex Research Site

City

Winter Haven

State/Province

Florida

ZIP/Postal Code

33880

Country

United States

Facility Name

Furiex Research Site

City

Winter Park

State/Province

Florida

ZIP/Postal Code

32792

Country

United States

Facility Name

Furiex Research Site

City

Alpharetta

State/Province

Georgia

ZIP/Postal Code

30005

Country

United States

Facility Name

Furiex Research Site

City

Athens

State/Province

Georgia

ZIP/Postal Code

30606

Country

United States

Facility Name

Furiex Research Site

City

Atlanta

State/Province

Georgia

ZIP/Postal Code

30308

Country

United States

Facility Name

Furiex Research Site

City

Atlanta

State/Province

Georgia

ZIP/Postal Code

30338

Country

United States

Facility Name

Furiex Research Site

City

Dunwoody

State/Province

Georgia

ZIP/Postal Code

30338

Country

United States

Facility Name

Furiex Research Site

City

Lawrenceville

State/Province

Georgia

ZIP/Postal Code

30046

Country

United States

Facility Name

Furiex Research Site

City

Macon

State/Province

Georgia

ZIP/Postal Code

31201

Country

United States

Facility Name

Furiex Research Site

City

Marietta

State/Province

Georgia

ZIP/Postal Code

30066

Country

United States

Facility Name

Furiex Research Site

City

Norcross

State/Province

Georgia

ZIP/Postal Code

30092

Country

United States

Facility Name

Furiex Research Site

City

Savannah

State/Province

Georgia

ZIP/Postal Code

31404

Country

United States

Facility Name

Furiex Research Site

City

Stockbridge

State/Province

Georgia

ZIP/Postal Code

30281

Country

United States

Facility Name

Furiex Research Site

City

Boise

State/Province

Idaho

ZIP/Postal Code

83704

Country

United States

Facility Name

Furiex Research Site

City

Eagle

State/Province

Idaho

ZIP/Postal Code

83616

Country

United States

Facility Name

Furiex Research Site

City

Idaho Falls

State/Province

Idaho

ZIP/Postal Code

83404

Country

United States

Facility Name

Furiex Research Site

City

Addison

State/Province

Illinois

ZIP/Postal Code

60101

Country

United States

Facility Name

Furiex Research Site

City

Chicago

State/Province

Illinois

ZIP/Postal Code

60612

Country

United States

Facility Name

Furiex Research Site

City

Chicago

State/Province

Illinois

ZIP/Postal Code

60622

Country

United States

Facility Name

Furiex Research Site

City

Evergreen Park

State/Province

Illinois

ZIP/Postal Code

60805

Country

United States

Facility Name

Furiex Research Site

City

Hammond

State/Province

Illinois

ZIP/Postal Code

46324

Country

United States

Facility Name

Furiex Research Site

City

Springfield

State/Province

Illinois

ZIP/Postal Code

62703

Country

United States

Facility Name

Furiex Research Site

City

Brownsburg

State/Province

Indiana

ZIP/Postal Code

46112

Country

United States

Facility Name

Furiex Research Site

City

Evansville

State/Province

Indiana

ZIP/Postal Code

47714

Country

United States

Facility Name

Furiex Research Site

City

Granger

State/Province

Indiana

ZIP/Postal Code

46530

Country

United States

Facility Name

Furiex Research Site

City

Clive

State/Province

Iowa

ZIP/Postal Code

50325

Country

United States

Facility Name

Furiex Research Site

City

Pratt

State/Province

Kansas

ZIP/Postal Code

67124

Country

United States

Facility Name

Furiex Research Site

City

Shawnee Mission

State/Province

Kansas

ZIP/Postal Code

66218

Country

United States

Facility Name

Furiex Research Site

City

Topeka

State/Province

Kansas

ZIP/Postal Code

66606

Country

United States

Facility Name

Furiex Research Site

City

Lexington

State/Province

Kentucky

ZIP/Postal Code

40503

Country

United States

Facility Name

Furiex Research Site

City

Lexington

State/Province

Kentucky

ZIP/Postal Code

40504

Country

United States

Facility Name

Furiex Research Site

City

Owensboro

State/Province

Kentucky

ZIP/Postal Code

42303

Country

United States

Facility Name

Furiex Research Site

City

Paducah

State/Province

Kentucky

ZIP/Postal Code

42003

Country

United States

Facility Name

Furiex Research Site

City

Lake Charles

State/Province

Louisiana

ZIP/Postal Code

70601

Country

United States

Facility Name

Furiex Research Site

City

Monroe

State/Province

Louisiana

ZIP/Postal Code

71201

Country

United States

Facility Name

Furiex Research Site

City

Hagerstown

State/Province

Maryland

ZIP/Postal Code

21742

Country

United States

Facility Name

Furiex Research Site

City

Hollywood

State/Province

Maryland

ZIP/Postal Code

20636

Country

United States

Facility Name

Furiex Research Site

City

Boston

State/Province

Massachusetts

ZIP/Postal Code

02115

Country

United States

Facility Name

Furiex Research Site

City

Boston

State/Province

Massachusetts

ZIP/Postal Code

02131

Country

United States

Facility Name

Furiex Research Site

City

Brockton

State/Province

Massachusetts

ZIP/Postal Code

02302

Country

United States

Facility Name

Furiex Research Site

City

Watertown

State/Province

Massachusetts

ZIP/Postal Code

02472

Country

United States

Facility Name

Furiex Research Site

City

Ann Arbor

State/Province

Michigan

ZIP/Postal Code

48106

Country

United States

Facility Name

Furiex Research Site

City

Bay City

State/Province

Michigan

ZIP/Postal Code

48706

Country

United States

Facility Name

Furiex Research Site

City

Cadillac

State/Province

Michigan

ZIP/Postal Code

49601

Country

United States

Facility Name

Furiex Research Site

City

Grand Rapids

State/Province

Michigan

ZIP/Postal Code

49506

Country

United States

Facility Name

Furiex Research Site

City

Kalamazoo

State/Province

Michigan

ZIP/Postal Code

49009

Country

United States

Facility Name

Furiex Research Site

City

Troy

State/Province

Michigan

ZIP/Postal Code

48098

Country

United States

Facility Name

Furiex Research Site

City

Ypsilanti

State/Province

Michigan

ZIP/Postal Code

48197

Country

United States

Facility Name

Furiex Research Site

City

Plymouth

State/Province

Minnesota

ZIP/Postal Code

55446

Country

United States

Facility Name

Furiex Research Site

City

Biloxi

State/Province

Mississippi

ZIP/Postal Code

39531

Country

United States

Facility Name

Furiex Research Site

City

Hazelwood

State/Province

Missouri

ZIP/Postal Code

63042

Country

United States

Facility Name

Furiex Research Site

City

Saint Louis

State/Province

Missouri

ZIP/Postal Code

63122

Country

United States

Facility Name

Furiex Research Site

City

Saint Louis

State/Province

Missouri

ZIP/Postal Code

63128

Country

United States

Facility Name

Furiex Research Site

City

Saint Louis

State/Province

Missouri

ZIP/Postal Code

63141

Country

United States

Facility Name

Furiex Research Site

City

Saint Peters

State/Province

Missouri

ZIP/Postal Code

63376

Country

United States

Facility Name

Furiex Research Site

City

Billings

State/Province

Montana

ZIP/Postal Code

59101

Country

United States

Facility Name

Furiex Research Site

City

Bellevue

State/Province

Nebraska

ZIP/Postal Code

68005

Country

United States

Facility Name

Furiex Research Site

City

Elkhorn

State/Province

Nebraska

ZIP/Postal Code

68022

Country

United States

Facility Name

Furiex Research Site

City

Lincoln

State/Province

Nebraska

ZIP/Postal Code

68510

Country

United States

Facility Name

Furiex Research Site

City

Omaha

State/Province

Nebraska

ZIP/Postal Code

68134

Country

United States

Facility Name

Furiex Research Site

City

Omaha

State/Province

Nebraska

ZIP/Postal Code

68144

Country

United States

Facility Name

Furiex Research Site

City

Las Vegas

State/Province

Nevada

ZIP/Postal Code

89123

Country

United States

Facility Name

Furiex Research Site

City

Reno

State/Province

Nevada

ZIP/Postal Code

89511

Country

United States

Facility Name

Furiex Research Site

City

Lebanon

State/Province

New Hampshire

ZIP/Postal Code

03756

Country

United States

Facility Name

Furiex Research Site

City

Blackwood

State/Province

New Jersey

ZIP/Postal Code

08012

Country

United States

Facility Name

Furiex Research Site

City

Edison

State/Province

New Jersey

ZIP/Postal Code

08817

Country

United States

Facility Name

Furiex Research Site

City

Elizabeth

State/Province

New Jersey

ZIP/Postal Code

07201

Country

United States

Facility Name

Furiex Research Site

City

Marlton

State/Province

New Jersey

ZIP/Postal Code

08053

Country

United States

Facility Name

Furiex Research Site

City

Albuquerque

State/Province

New Mexico

ZIP/Postal Code

87102

Country

United States

Facility Name

Furiex Research Site

City

Albuquerque

State/Province

New Mexico

ZIP/Postal Code

87108

Country

United States

Facility Name

Furiex Research Site

City

Albuquerque

State/Province

New Mexico

ZIP/Postal Code

87109

Country

United States

Facility Name

Furiex Research Site

City

Flushing

State/Province

New York

ZIP/Postal Code

11367

Country

United States

Facility Name

Furiex Research Site

City

Hollis

State/Province

New York

ZIP/Postal Code

11423

Country

United States

Facility Name

Furiex Research Site

City

Mineola

State/Province

New York

ZIP/Postal Code

11501

Country

United States

Facility Name

Furiex Research Site

City

New York

State/Province

New York

ZIP/Postal Code

10016

Country

United States

Facility Name

Furiex Research Site

City

Chapel Hill

State/Province

North Carolina

ZIP/Postal Code

27599

Country

United States

Facility Name

Furiex Research Site

City

Dunn

State/Province

North Carolina

ZIP/Postal Code

28334

Country

United States

Facility Name

Furiex Research Site

City

Greensboro

State/Province

North Carolina

ZIP/Postal Code

27403

Country

United States

Facility Name

Furiex Research Site

City

Huntersville

State/Province

North Carolina

ZIP/Postal Code

28078

Country

United States

Facility Name

Furiex Research Site

City

Kinston

State/Province

North Carolina

ZIP/Postal Code

28501

Country

United States

Facility Name

Furiex Research Site

City

Wilmington

State/Province

North Carolina

ZIP/Postal Code

28403

Country

United States

Facility Name

Furiex Research Site

City

Winston-Salem

State/Province

North Carolina

ZIP/Postal Code

27103

Country

United States

Facility Name

Furiex Research Site

City

Winston-Salem

State/Province

North Carolina

ZIP/Postal Code

27106

Country

United States

Facility Name

Furiex Research Site

City

Akron

State/Province

Ohio

ZIP/Postal Code

44302

Country

United States

Facility Name

Furiex Research Site

City

Beavercreek

State/Province

Ohio

ZIP/Postal Code

45431

Country

United States

Facility Name

Furiex Research Site

City

Cincinnati

State/Province

Ohio

ZIP/Postal Code

45224

Country

United States

Facility Name

Furiex Research Site

City

Cincinnati

State/Province

Ohio

ZIP/Postal Code

45242

Country

United States

Facility Name

Furiex Research Site

City

Cincinnati

State/Province

Ohio

ZIP/Postal Code

45245

Country

United States

Facility Name

Furiex Research Site

City

Cincinnati

State/Province

Ohio

ZIP/Postal Code

45267

Country

United States

Facility Name

Furiex Research Site

City

Cleveland

State/Province

Ohio

ZIP/Postal Code

44122

Country

United States

Facility Name

Furiex Research Site

City

Columbus

State/Province

Ohio

ZIP/Postal Code

43212

Country

United States

Facility Name

Furiex Research Site

City

Columbus

State/Province

Ohio

ZIP/Postal Code

43214

Country

United States

Facility Name

Furiex Research Site

City

Columbus

State/Province

Ohio

ZIP/Postal Code

43235

Country

United States

Facility Name

Furiex Research Site

City

Dayton

State/Province

Ohio

ZIP/Postal Code

45432

Country

United States

Facility Name

Furiex Research Site

City

Dayton

State/Province

Ohio

ZIP/Postal Code

45439

Country

United States

Facility Name

Furiex Research Site

City

Groveport

State/Province

Ohio

ZIP/Postal Code

43125

Country

United States

Facility Name

Furiex Research Site

City

Kettering

State/Province

Ohio

ZIP/Postal Code

45429

Country

United States

Facility Name

Furiex Research Site

City

Lima

State/Province

Ohio

ZIP/Postal Code

45806

Country

United States

Facility Name

Furiex Research Site

City

Tiffin

State/Province

Ohio

ZIP/Postal Code

44883

Country

United States

Facility Name

Furiex Research Site

City

Toledo

State/Province

Ohio

ZIP/Postal Code

43615

Country

United States

Facility Name

Furiex Research Site

City

Norman

State/Province

Oklahoma

ZIP/Postal Code

73071

Country

United States

Facility Name

Furiex Research Site

City

Oklahoma City

State/Province

Oklahoma

ZIP/Postal Code

73102

Country

United States

Facility Name

Furiex Research Site

City

Oklahoma City

State/Province

Oklahoma

ZIP/Postal Code

73112

Country

United States

Facility Name

Furiex Research Site

City

Portland

State/Province

Oregon

ZIP/Postal Code

97210

Country

United States

Facility Name

Furiex Research Site

City

Salem

State/Province

Oregon

ZIP/Postal Code

97301

Country

United States

Facility Name

Furiex Research Site

City

Carnegie

State/Province

Pennsylvania

ZIP/Postal Code

15106

Country

United States

Facility Name

Furiex Research Site

City

Philadelphia

State/Province

Pennsylvania

ZIP/Postal Code

19107

Country

United States

Facility Name

Furiex Research Site

City

Pittsburgh

State/Province

Pennsylvania

ZIP/Postal Code

15206

Country

United States

Facility Name

Furiex Research Site

City

Pittsburgh

State/Province

Pennsylvania

ZIP/Postal Code

15243

Country

United States

Facility Name

Furiex Research Site

City

Scottdale

State/Province

Pennsylvania

ZIP/Postal Code

15683

Country

United States

Facility Name

Furiex Research Site

City

Uniontown

State/Province

Pennsylvania

ZIP/Postal Code

15401

Country

United States

Facility Name

Furiex Research Site

City

Warwick

State/Province

Rhode Island

ZIP/Postal Code

02888

Country

United States

Facility Name

Furiex Research Site

City

Anderson

State/Province

South Carolina

ZIP/Postal Code

29621

Country

United States

Facility Name

Furiex Research Site

City

Columbia

State/Province

South Carolina

ZIP/Postal Code

29201

Country

United States

Facility Name

Furiex Research Site

City

Columbia

State/Province

South Carolina

ZIP/Postal Code

29203

Country

United States

Facility Name

Furiex Research Site

City

Columbia

State/Province

South Carolina

ZIP/Postal Code

29204

Country

United States

Facility Name

Furiex Research Site

City

Easley

State/Province

South Carolina

ZIP/Postal Code

29640

Country

United States

Facility Name

Furiex Research Site

City

Mount Pleasant

State/Province

South Carolina

ZIP/Postal Code

29464

Country

United States

Facility Name

Furiex Research Site

City

North Myrtle Beach

State/Province

South Carolina

ZIP/Postal Code

29582

Country

United States

Facility Name

Furiex Research Site

City

Rapid City

State/Province

South Dakota

ZIP/Postal Code

57702

Country

United States

Facility Name

Furiex Research Site

City

Athens

State/Province

Tennessee

ZIP/Postal Code

37303

Country

United States

Facility Name

Furiex Research Site

City

Chattanooga

State/Province

Tennessee

ZIP/Postal Code

37404

Country

United States

Facility Name

Furiex Research Site

City

Columbia

State/Province

Tennessee

ZIP/Postal Code

38401

Country

United States

Facility Name

Furiex Research Site

City

Jackson

State/Province

Tennessee

ZIP/Postal Code

38305

Country

United States

Facility Name

Furiex Research Site

City

Knoxville

State/Province

Tennessee

ZIP/Postal Code

37919

Country

United States

Facility Name

Furiex Research Site

City

Smyrna

State/Province

Tennessee

ZIP/Postal Code

37167

Country

United States

Facility Name

Furiex Research Site

City

Austin

State/Province

Texas

ZIP/Postal Code

78745

Country

United States

Facility Name

Furiex Research Site

City

Beaumont

State/Province

Texas

ZIP/Postal Code

77701

Country

United States

Facility Name

Furiex Research Site

City

Bedford

State/Province

Texas

ZIP/Postal Code

76021

Country

United States

Facility Name

Furiex Research Site

City

Corsicana

State/Province

Texas

ZIP/Postal Code

75110

Country

United States

Facility Name

Furiex Research Site

City

Dallas

State/Province

Texas

ZIP/Postal Code

75218

Country

United States

Facility Name

Furiex Research Site

City

Dallas

State/Province

Texas

ZIP/Postal Code

75225

Country

United States

Facility Name

Furiex Research Site

City

Fort Worth

State/Province

Texas

ZIP/Postal Code

76133

Country

United States

Facility Name

Furiex Research Site

City

Frisco

State/Province

Texas

ZIP/Postal Code

75035

Country

United States

Facility Name

Furiex Research Site

City

Houston

State/Province

Texas

ZIP/Postal Code

77008

Country

United States

Facility Name

Furiex Research Site

City

Houston

State/Province

Texas

ZIP/Postal Code

77043

Country

United States

Facility Name

Furiex Research Site

City

Houston

State/Province

Texas

ZIP/Postal Code

77062

Country

United States

Facility Name

Furiex Research Site

City

Humble

State/Province

Texas

ZIP/Postal Code

77338

Country

United States

Facility Name

Furiex Research Site

City

Hurst

State/Province

Texas

ZIP/Postal Code

76054

Country

United States

Facility Name

Furiex Research Site

City

San Antonio

State/Province

Texas

ZIP/Postal Code

78215

Country

United States

Facility Name

Furiex Research Site

City

San Antonio

State/Province

Texas

ZIP/Postal Code

78229

Country

United States

Facility Name

Furiex Research Site

City

San Antonio

State/Province

Texas

ZIP/Postal Code

78258

Country

United States

Facility Name

Furiex Research Site

City

Bountiful

State/Province

Utah

ZIP/Postal Code

84010

Country

United States

Facility Name

Furiex Research Site

City

Salt Lake City

State/Province

Utah

ZIP/Postal Code

84124

Country

United States

Facility Name

Furiex Research Site

City

West Valley City

State/Province

Utah

ZIP/Postal Code

84120

Country

United States

Facility Name

Furiex Research Site

City

Burlington

State/Province

Vermont

ZIP/Postal Code

05401

Country

United States

Facility Name

Furiex Research Site

City

Alexandria

State/Province

Virginia

ZIP/Postal Code

22304

Country

United States

Facility Name

Furiex Research Site

City

Christiansburg

State/Province

Virginia

ZIP/Postal Code

24073

Country

United States

Facility Name

Furiex Research Site

City

Midlothian

State/Province

Virginia

ZIP/Postal Code

23114

Country

United States

Facility Name

Furiex Research Site

City

Norfolk

State/Province

Virginia

ZIP/Postal Code

23502

Country

United States

Facility Name

Furiex Research Site

City

Richmond

State/Province

Virginia

ZIP/Postal Code

23233

Country

United States

Facility Name

Furiex Research Site

City

Richmond

State/Province

Virginia

ZIP/Postal Code

23235

Country

United States

Facility Name

Furiex Research Site

City

Charleston

State/Province

West Virginia

ZIP/Postal Code

25304

Country

United States

Facility Name

Furiex Research Site

City

Monroe

State/Province

Wisconsin

ZIP/Postal Code

53566

Country

United States

Facility Name

Furiex Research Site

City

Kelowna

State/Province

British Columbia

ZIP/Postal Code

V1Y 3G8

Country

Canada

Facility Name

Furiex Research Site

City

St. John's

State/Province

Newfoundland and Labrador

ZIP/Postal Code

A1E 2E2

Country

Canada

Facility Name

Furiex Research Site

City

Burlington

State/Province

Ontario

ZIP/Postal Code

L7M 4Y1

Country

Canada

Facility Name

Furiex Research Site

City

Hawkesbury

State/Province

Ontario

ZIP/Postal Code

K6A 1A1

Country

Canada

Facility Name

Furiex Research Site

City

London

State/Province

Ontario

ZIP/Postal Code

N5W 6A2

Country

Canada

Facility Name

Furiex Research Site

City

Newmarket

State/Province

Ontario

ZIP/Postal Code

L3Y 5G8

Country

Canada

Facility Name

Furiex Research Site

City

Sarnia

State/Province

Ontario

ZIP/Postal Code

N7T 4X3

Country

Canada

Facility Name

Furiex Research Site

City

Sudbury

State/Province

Ontario

ZIP/Postal Code

P3E 1H5

Country

Canada

Facility Name

Furiex Research Site

City

Toronto

State/Province

Ontario

ZIP/Postal Code

M6H 3M1

Country

Canada

Facility Name

Furiex Research Site

City

Vaughan

State/Province

Ontario

ZIP/Postal Code

L4L 4Y7

Country

Canada

Facility Name

Furiex Research Site

City

San Juan

ZIP/Postal Code

00926-2832

Country

Puerto Rico

Facility Name

Furiex Research Site

City

Chestfield

State/Province

Kent

ZIP/Postal Code

CT5 3QS

Country

United Kingdom

Facility Name

Furiex Research Site

City

Blackpool

State/Province

Lancashire

ZIP/Postal Code

FY4 3AD

Country

United Kingdom

Facility Name

Furiex Research Site

City

Birmingham

ZIP/Postal Code

B15 2TH

Country

United Kingdom

Facility Name

Furiex Research Site

City

County Durham

ZIP/Postal Code

DL14 6AD

Country

United Kingdom

Facility Name

Furiex Research Site

City

Coventry

ZIP/Postal Code

CV2 2DX

Country

United Kingdom

Facility Name

Furiex Research Site

City

Durham

ZIP/Postal Code

DH1 5TW

Country

United Kingdom

Facility Name

Furiex Research Site

City

Edinburgh

ZIP/Postal Code

EH4 2XH

Country

United Kingdom

Facility Name

Furiex Research Site

City

Manchester

ZIP/Postal Code

M23 9LT

Country

United Kingdom

Facility Name

Furiex Research Site

City

Sheffield

ZIP/Postal Code

S10 2JF

Country

United Kingdom

Facility Name

Furiex Research Site

City

Wigan

ZIP/Postal Code

WN1 2NN

Country

United Kingdom

12. IPD Sharing Statement

Citations:

PubMed Identifier

28167156

Citation

Fant RV, Henningfield JE, Cash BD, Dove LS, Covington PS. Eluxadoline Demonstrates a Lack of Abuse Potential in Phase 2 and 3 Studies of Patients With Irritable Bowel Syndrome With Diarrhea. Clin Gastroenterol Hepatol. 2017 Jul;15(7):1021-1029.e6. doi: 10.1016/j.cgh.2017.01.026. Epub 2017 Feb 3.

Results Reference

derived

PubMed Identifier

26789872

Citation

Lembo AJ, Lacy BE, Zuckerman MJ, Schey R, Dove LS, Andrae DA, Davenport JM, McIntyre G, Lopez R, Turner L, Covington PS. Eluxadoline for Irritable Bowel Syndrome with Diarrhea. N Engl J Med. 2016 Jan 21;374(3):242-53. doi: 10.1056/NEJMoa1505180.

Results Reference

derived

Learn more about this trial

Efficacy, Safety, and Tolerability of Eluxadoline in the Treatment of Participants With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-d)

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Efficacy, Safety, and Tolerability of Eluxadoline in the Treatment of Participants With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-d)

Irritable Bowel Syndrome

About this trial

Eligibility Criteria

Sites / Locations

Arms of the Study

Arm 1

Arm 2

Arm 3

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

1. Study Identification

2. Study Status

3. Sponsor/Collaborators

4. Oversight

5. Study Description

6. Conditions and Keywords

7. Study Design

8. Arms, Groups, and Interventions

10. Eligibility

12. IPD Sharing Statement

Learn more about this trial