Electrical Intra-cutaneous Half-sine Stimulation for Optimized Preferential C-fiber Activation
Pain Perception, Secondary Hyperalgesia
About this trial
This is an interventional basic science trial for Pain Perception focused on measuring C-fiber activation, evoked pain, hyperalgesia, allodynia, half-sine stimulation, 25ms HS stimulation, pain perception, nociceptors, rectangular current stimulation, electrical pain model, numeric rating scale (NRS)
Eligibility Criteria
Inclusion Criteria:
- Healthy adults (18 - 65 years old, American Society of Anaesthesiologists (ASA) I or II)
- BMI between 18.5 until 25 kg/m2
- Able to understand the study and the NRS scale
- Able to give informed consent
Exclusion Criteria:
- Regular intake of medications or drugs potentially interfering with pain sensation (analgesics, opioids, antihistamines, calcium and potassium channel blockers, serotonin / noradrenaline reuptake inhibitors, corticosteroids)
- Neuropathy
- Chronic pain
- Neuromuscular disease
- Dermatological disease as Atopic Dermatitis
- Psychiatric disease
- Pregnancy / Lactation
Sites / Locations
- Department of Anaesthesiology, University Hospital of Basel (USB)Recruiting
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
First: half-sine wave stimulation; Second: rectangular shaped stimulation
First: rectangular shaped stimulation; Second: half-sine wave stimulation
First appointment: Intracutaneously applied electrical 25 ms half-sine wave stimulation with 2 Hz frequency. Second appointment: Intracutaneously applied electrical 500 µs rectangular shaped stimulation with 2 Hz frequency.
First appointment: Intracutaneously applied electrical 500 µs rectangular shaped stimulation with 2 Hz frequency. Second appointment: Intracutaneously applied electrical 25 ms half-sine wave stimulation with 2 Hz frequency.