Enabling Personalized Medicine Through Exome Sequencing in the U.S. Air Force (MilSeq)
Healthy Adults, Genetic Predisposition to Disease
About this trial
This is an interventional health services research trial for Healthy Adults focused on measuring Whole Genome Sequencing, Whole Exome Sequencing, Military, Air Force, Disease Susceptibility, Genetic Predisposition to Disease, Disease Attributes, Pathologic Processes
Eligibility Criteria
Patient-Participant Inclusion Criteria:
- 18 years or older
- An active Air Force Airman
- Fluent in English
- Seen or eligible to be seen by a provider at Wilford Hall Ambulatory Surgical Center at Joint Base San Antonio (JBSA) Lackland Air Force Base
Healthcare Provider-Participant Inclusion Criterion
- An active or Department of Defense civilian Primary Care, Internal Medicine, or Family Practice Healthcare Provider (Physician, Physician Assistant, or Nurse Practitioner) or resident practicing at Wilford Hall Ambulatory Surgical Center at JBSA Lackland Air Force Base
Patient-Participant Exclusion Criteria:
- Those who do not meet the above inclusion criteria
- Those with clinically concerning scores on anxiety and distress scales in baseline survey
- Trainees (basic military training or tech school)
- Airmen with an active change of duty station order or deployment order and expected to leave San Antonio in 6 months or less
- Airmen expected to be discharged from the Air Force in 6 months or less
Healthcare Provider-Participant Exclusion Criteria:
- Providers who do not meet the above inclusion criteria
- Providers with an active change of duty station order or deployment order and expected to leave San Antonio in 6 months or less
- Providers expected to be discharged from the Air Force in 6 months or less
Sites / Locations
- Brigham and Women's Hospital
- Baylor College of Medicine
- Joint Base San Antonio Lackland Air Force Base - 59th Medical Wing
Arms of the Study
Arm 1
Experimental
Healthy Active-Duty Airmen Cohort
Whole exome sequencing (WES) will be performed on 75 ostensibly healthy, active-duty Airmen (patient-participants) who receive medical care in military Primary Care, Internal Medicine and/or Family Practice settings who in their baseline survey expressed interest in receiving WES. Military healthcare providers who have received brief genomics training will return results to the patient-participants and the WES reports will be permanently integrated into their electronic medical record.