Enamel Matrix Proteins in the Treatment of Intrabony Defects in Patients With Aggressive and Chronic Periodontitis
Aggressive Periodontitis
About this trial
This is an interventional treatment trial for Aggressive Periodontitis focused on measuring Regeneration Procedures, Intrabony Defects, Cronic Periodontitis
Eligibility Criteria
Inclusion Criteria:
- Diagnosis of generalized aggressive periodontitis (verified by the presence of periodontal pockets and radiological loss in patients under the 35 years old at the time of diagnosis); or a diagnosis of generalized chronic periodontitis (in patients over 35 years old);
- Presence of infra-osseous defect in radiographic examination with minimum dimensions of 4mm deep and 2mm of horizontal component, associated to periodontal pocket of at least 6mm of PD;
- Presence of at least 15 teeth of the oral cavity;
- To present less than 20% of plaque index and bleeding on probing after 6 weeks of initial therapy;
- Formal consent for participation in research, after explaining the risks and benefits for individual not involved in it. (Resolution No. 196 of October 1996 and the Dental Code of Professional Ethics (C.F.O.) 179/93).
Exclusion Criteria:
Presence of periapical or pulpal alteration;
- Presence of systemic alteration or use of medications (6 months prior to the study) that may influence the response to periodontal treatment;
- Pregnant and lactating women;
- Smoking;
- Periodontal treatment including subgingival instrumentation in the 6 weeks prior to the study;
- Teeth with bifurcation involvement;
- Teeth with marked mobility;
- Oral pathology, chronic disease or history of allergy to any component of the study;
- Previous periodontal surgery in the region of interest.
Sites / Locations
- Piracicaba Dental School, State University of Campinas
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Experimental
Active Comparator
GAP Surgical Access (GAP + OFD, 15 patients)
GAP Surgical Access + EMD (GAP + OFD/EMD, 15 patients)
GCP Surgical Access + EMD (GCP + OFD/EMD, 15 patients)
Patients diagnosed with generalized aggressive periodontitis (GAP), in which the previously selected intrabony defect will receive will receive open flap debridement.
Patients with a diagnosis of generalized aggressive periodontitis (GAP), in which the previously selected intrabony defect will receive open flap debridement and, in addition, application of the EMD in the defect.
Patients with a diagnosis of generalized chronic periodontitis (GCP), in which the previously selected intrabony defect will receive open flap debridement and, in addition, application of the EMD in the defect.