Endometrial Biopsy Prior to IVF in Those Patients With Prior Implantation Failure (EMBX/IVF)
Implantation Failure, Infertility
About this trial
This is an interventional treatment trial for Implantation Failure focused on measuring Implantation Failure, In-vitro Fertilization, Infertility, Endometrial Biopsy
Eligibility Criteria
Inclusion Criteria:
- Women age 18-37
- One or more previous implantation failures with autologous fresh or frozen blastocyst transfer
- Undergoing fresh autologous IVF cycle
- No other current uterine (i.e.: uterine fibroids, polyps), hematologic, or genetic causes for infertility and implantation failure
- One or more good quality blastocyst(s) available for transfer
Exclusion Criteria:
- Those unable to comprehend the investigational nature of the proposed study
- Positive pregnancy test
- Possible causes for impaired implantation (systemic disease, endometriosis, ultrasound evidence of current hydrosalpinx, uterine polyps, uterine myomas (fibroids), uterine cavity malformations or Asherman's syndrome)
- Poor responders, defined as FSH >12 on day 3 or less than 4 follicles on a previous IVF cycle
- BMI >30 or <18
Sites / Locations
- Shady Grove Fertility Reproductive Science CenterRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Sham Comparator
Endometrial Biopsy
Control
Subjects will have a vaginal speculum placed and visualization of the cervix will be obtained. The cervix will be cleaned with betadine (or hibiclens for those with an iodine allergy). Those randomized to the treatment arm (endometrial biopsy) will have an endometrial pipelle (Endocell, Wallach, Orange, Connecticut) inserted gently through the cervix into the uterus. Two passes will be performed with the pipelle catheter. For each pass the catheter will be rotated and scraped 4 times, once in each quadrant.
Those randomized to the control group will have a small cotton swab placed gently into the cervix. No tissue will be obtained with this method. The randomization to a placebo control is necessary to prove that any positive effects seen are due to the biopsy and not just random chance.