Endometrial Local Injury to Improve the Outcome of Embryo Transfer

Endometrial Local Injury of Frozen Cycle to Improve the Outcome of Embryo Transfer of Repeated Implantation Failure.

The purpose of this study is to determine whether edometrial local injury improves the outcome of embryo transfer,and to find out more evidence about the time of trauma,the way of intervention,and the possible mechanism.

It is important to evaluate the efficacy of endometrial local injury in assisted reproductive technology(ART),especially on the patients of recurrent implantation failure. Although most trials proved the effectiveness of the intervention of local injury, the subjects of these trials are rarely the patients of repeated implantation failure(RIF). Moreover, the mechanism of endometrial injury is not clear.Our trial may provide further basis for this purpose by comparing to the quality of endometrium in two-dimensional ultrasound.If the technique demonstrates efficacy, it would help the patients with RIF caused by poor conditions of endometrium to deal with the problem of infertility.

Endometrial local injury is carried in the first 3-5 days after menstrual period at the same time of hysteroscopy.

Any processing does not carry on the endometrium in the first 3-5 days after menstrual period except hysteroscopy.

The way of intervention is to scratch the uterine cavity two cycles by a small spatula in the first 3-5 days after menstrual period.

When serum HCG is continuously more than 100mIU/ml and gestational sac is detected by ultrasound,it is considered as implantation.

including endometrial thickness, echo, blood flow and uterine cavity volume, uterine vascularization index, flow index.

Inclusion Criteria: Women with RIF(≥2) of embyo transfer and uneven echo of endometrium on HCG day(12-14 days) Without operation history of uterine cavity in the previous three months Who agree to join in the study Exclusion Criteria: Women more than 40 years or less than 20 years With infectious diseases or endocrine diseases Who refuse to participate in the experiment

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