Endoscopic Biopsy Techniques in Barrett's Esophagus Patients (BITE)
Barrett Esophagus
About this trial
This is an interventional diagnostic trial for Barrett Esophagus
Eligibility Criteria
Inclusion Criteria:
- Age 18 years or older
- A diagnosis of Barrett's esophagus (maximum length ≥ 1cm)
- Scheduled for surveillance endoscopy with random biopsies
In addition to the abovementioned inclusion criteria, a subject must meet the following criteria to participate in:
Part I: endoscopy performed by BE expert or non-BE expert endoscopists Part II: endoscopy performed by BE expert endoscopist Part III: endoscopy performed by non-BE expert endoscopist
Exclusion Criteria:
- Very long BE segment (maximum length ≥ 10cm)
- Any known clinical contraindication for obtaining biopsies (e.g. oesophageal varices, uncontrolled coagulopathy)
Biopsies of suspicious lesions in the Barrett's epithelium will be excluded from analysis in all parts of this study. In case of suspicious lesions, endoscopists (in part II and part III of the BITE study) are allowed to obtain biopsies according to the technique they prefer.
Sites / Locations
- St. Antonius ZiekenhuisRecruiting
- University Medical Center UtrechtRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Other
Other
Other
Other
A
B
C
D
Single-biopsy advance-and-close
Single-biopsy turn-and-suction
Double-biopsy advance-and-close
Double-biopsy turn-and-suction