Endoscopic Treatment of Gastroesophageal Reflux Disease
Gastro Esophageal Reflux Disease
About this trial
This is an interventional treatment trial for Gastro Esophageal Reflux Disease
Eligibility Criteria
Inclusion Criteria (both criteria must be fulfilled): GERD. GERD must be diagnosed by either endoscopic esophagitis or esophageal pH measurement with DeMeester score > 14.72 and pH <4 more than 4% of a 24-h period and symptom association probability (SAP) > 95% Subjective insufficient symptom control with PPI therapy once daily or intolerance to PPI or desire to stop PPI treatment and therefore willingness to undergo endoscopic treatment. Exclusion Criteria: Hiatal hernia > 2 cm Age < 18_years Previous esophageal or gastric surgery, Preexisting esophageal stricture Anti-coagulant medication Use of platelet inhibitors other than acetylsalicylic acid Manometric indication of motility disorder Connective tissue diseases BMI > 30 Chronic liver disease Coronary heart disease Chronic obstructive pulmonary disease Other significant comorbidity Indication for long-term PPI use other than GERD
Sites / Locations
- St.Olavs Hospital
Arms of the Study
Arm 1
Experimental
Endoscopic mucosal band ligation
All 12 patients with GERD will undergo the same procedure. Multiple rubber bands will be used to ligate mucosa in the gastroesophageal junction and cardia in 3/4 of the circumference.