Endoscopic Tri-Modal Imaging to Distinguish Functional Dyspepsia From Reflux Disease
Gastroesophageal Reflux Disease, Dyspepsia, Bile Reflux
About this trial
This is an interventional diagnostic trial for Gastroesophageal Reflux Disease focused on measuring Endoscopic Tri-Modal Imaging, Gastric juice, Functional dyspepsia, Acid reflux disease, Bile reflux
Eligibility Criteria
Inclusion Criteria:
- symptoms suggestive of GERD or dyspepsia.
- Presence of symptom for longer than 6 month
- Provision of written informed consent
Exclusion Criteria:
- Any known upper GI disease, other than reflux esophagitis
- Active or healing gastroduodenal ulcer (except scars)
- History of esophageal or gastric surgery.
- Clinically significant heart, lung, liver or kidney disease
- Allergy to proton-pump inhibitor
- Pregnancy
Sites / Locations
- Chinese PLA General Hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Experimental
Experimental
Functional dyspepsia
Acid reflux disease
Bile reflux disease
Health volunteers
Participants are to undergo Endoscopic Tri-Modal Imaging, Omeprazole test and Analysis of gastric juice and those who fulfill with Rome III criteria for functional dyspepsia are to be classified into this group.
Participants are to undergo Endoscopic Tri-Modal Imaging, Omeprazole test and Analysis of gastric juice. Participants with acid reflux are to confirmed by Omeprazole test, one kind of proton-pump inhibitor (PPI) tests.
Participants are to undergo Endoscopic Tri-Modal Imaging and Analysis of gastric juice. Participants with bile reflux are to be confirmed by Analysis of gastric juice.
Health volunteers for routine checkup. Participants are to undergo Endoscopic Tri-Modal Imaging as well as Analysis of gastric juice and those who show no abnormal findings are to be classified into this group.