Energy Restriction and Hormones in Premenopausal Women
Menstruation Disturbances, Luteal Phase Defect
About this trial
This is an interventional treatment trial for Menstruation Disturbances focused on measuring Energy Balance, Menstrual Cycle Disturbance, Luteal Phase Defect, Menstruation Disturbances, Pathologic Processes
Eligibility Criteria
Inclusion Criteria:
- Weight 50-90 kg
- BMI 18-35 kg/m2
- Nonsmoking
- <1 hour/week of purposeful aerobic exercise for the past 6 months
- Gynecological age ≥10 years
- Documentation of at least two ovulatory menstrual cycles during screening.
Exclusion Criteria:
- History of serious medical conditions
- Medication use that would alter metabolic hormone levels
- Significant weight loss/gain (±2.3 kg) in the last year
- Current evidence of disordered eating or history of an eating disorder
- Taking exogenous hormonal contraceptives for the past 6 month
- Smoking
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Exercise with caloric-restriction
Light Conditioning (reference group)
Exercise: Participants engaged in supervised exercise training sessions (to expend ~20% of baseline energy needs) in Noll Laboratory; 4 times per week. Diet: Participants consumed meals in the General Clinical Research Center metabolic kitchen that reduced dietary intake 20-35% of baseline energy needs. Diet composition was 55% carbohydrates, 30% fat, and 15% protein.
Exercise: Participants engaged in supervised exercise training sessions (to expend ~10% of baseline energy needs) in Noll Laboratory; 1-2 times per week. Diet: Participants consumed meals in the General Clinical Research Center metabolic kitchen that had calories sufficient to maintain body weight and additional calories to remain in energy balance. Diet composition was 55% carbohydrates, 30% fat, and 15% protein.