Epidemiology of SARS-CoV-2 and Mortality to Covid19 Disease in French Cancer Patients (ONCOVID)
Primary Purpose
Cancer & COVID 19
Status
Unknown status
Phase
Phase 2
Locations
France
Study Type
Interventional
Intervention
Hydroxychloroquine
Azithromycin
Sponsored by
About this trial
This is an interventional treatment trial for Cancer & COVID 19
Eligibility Criteria
Inclusion Criteria:
- All types of locally advanced and metastatic malignancy
- Male/female participants
- Age>18 y.o.
- Signed informed consent for participation in the study
- No restriction on Eastern Cooperative Oncology Group (ECOG)/World Health Organization (WHO) Performance Status
- Subject should not have received a prior systemic anti-viral treatment for Covid19 disease.
Exclusion Criteria:
- Patients with known hypersensitivity to hydroxychloroquine or chloroquine, azithromycin, erythromycin, or any other macrolide, ketolide or any of the excipients of the hydroxychloroquine and/or azithromycin-based specialty used.
- Severe hepatic impairment and patients with severe cholestasis.
- Patients with renal insufficiency with creatinine clearance < 40 mL/min.
- Combinations of drugs contraindicated in accordance with the approvals of the specialties used.
- Patients currently treated with Tamoxifen
- Patients already treated by hydroxychloroquine or azithromycin for Covid19 disease or currently treated with other antiviral drugs against coronavirus.
- Patients with known contra-indication to treatment with the study drug, including retinopathy, G6PD deficiency, QT prolongation and severe hepato-cellular insufficiency.
- Patients post allogeneic hematopoietic stem cell transplantation are eligible to the Part B treatments but the potential toxic effects of hydroxychloroquin and azithromycin on hematopoietic stem cells should be taken into consideration by prescribers.
- Pregnant or breastfeeding women. Women of childbearing potential (WOCBP, as defined in appendix 2) should have a negative urine or serum pregnancy test within 72 hours prior to receiving the first dose of study medication. If the urine test is positive or cannot be confirmed as negative, a serum pregnancy test will be required.
Sites / Locations
- Gustave RoussyRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm Type
Experimental
No Intervention
No Intervention
Experimental
Arm Label
Cohort 1
Cohort 2
Cohort 3
Cohort 4
Arm Description
Advanced Cancer Patients with SARS-CoV-2 positive test & Covid19 symptoms
Advanced Cancer Patients with SARS-CoV-2 negative test & Covid19 symptoms. Patients with a chest CT-scan compatible with Covid19 disease shall be treated in part B.
Advanced Cancer Patients with SARS-CoV-2 positive or negative test & no Covid19 symptoms
Advanced Cancer Patients with SARS-CoV-2 positive test AND chest CT-scan compatible with Covid19 disease & no Covid19 symptoms & Pretreated or with frail conditions following the HCSP definition
Outcomes
Primary Outcome Measures
Prevalence and the 3-months incidence of SARS-CoV-2 in cancer patients
Covid-19 disease-specific mortality rate in cancer patients treated by hydroxychloroquine and azithromycin
Secondary Outcome Measures
Full Information
NCT ID
NCT04341207
First Posted
April 8, 2020
Last Updated
April 9, 2020
Sponsor
Gustave Roussy, Cancer Campus, Grand Paris
1. Study Identification
Unique Protocol Identification Number
NCT04341207
Brief Title
Epidemiology of SARS-CoV-2 and Mortality to Covid19 Disease in French Cancer Patients
Acronym
ONCOVID
Official Title
COVID 19 - Epidemiology of SARS-CoV-2 and Mortality to Covid19 Disease Upon Hydroxychloroquine and Azithromycin Therapy in French Cancer Patients
Study Type
Interventional
2. Study Status
Record Verification Date
April 2020
Overall Recruitment Status
Unknown status
Study Start Date
April 3, 2020 (Actual)
Primary Completion Date
April 2022 (Anticipated)
Study Completion Date
April 2022 (Anticipated)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Gustave Roussy, Cancer Campus, Grand Paris
4. Oversight
Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
Yes
5. Study Description
Brief Summary
To determine the prevalence and the 3-months incidence of SARS-CoV-2 in cancer patients (Part A).
To evaluate the Covid-19 disease-specific mortality rate in cancer patients treated by hydroxychloroquine and azithromycin (Part B).
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Cancer & COVID 19
7. Study Design
Primary Purpose
Treatment
Study Phase
Phase 2
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Non-Randomized
Enrollment
1000 (Anticipated)
8. Arms, Groups, and Interventions
Arm Title
Cohort 1
Arm Type
Experimental
Arm Description
Advanced Cancer Patients with SARS-CoV-2 positive test & Covid19 symptoms
Arm Title
Cohort 2
Arm Type
No Intervention
Arm Description
Advanced Cancer Patients with SARS-CoV-2 negative test & Covid19 symptoms. Patients with a chest CT-scan compatible with Covid19 disease shall be treated in part B.
Arm Title
Cohort 3
Arm Type
No Intervention
Arm Description
Advanced Cancer Patients with SARS-CoV-2 positive or negative test & no Covid19 symptoms
Arm Title
Cohort 4
Arm Type
Experimental
Arm Description
Advanced Cancer Patients with SARS-CoV-2 positive test AND chest CT-scan compatible with Covid19 disease & no Covid19 symptoms & Pretreated or with frail conditions following the HCSP definition
Intervention Type
Drug
Intervention Name(s)
Hydroxychloroquine
Intervention Description
Hydroxychloroquine 200 mg 3 times a day for 10 days
Intervention Type
Drug
Intervention Name(s)
Azithromycin
Intervention Description
Azithromycin 500 mg on day 1 followed by 250 mg/day for 4 days
Primary Outcome Measure Information:
Title
Prevalence and the 3-months incidence of SARS-CoV-2 in cancer patients
Time Frame
Up to 3 months
Title
Covid-19 disease-specific mortality rate in cancer patients treated by hydroxychloroquine and azithromycin
Time Frame
Up to 12 months
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
All types of locally advanced and metastatic malignancy
Male/female participants
Age>18 y.o.
Signed informed consent for participation in the study
No restriction on Eastern Cooperative Oncology Group (ECOG)/World Health Organization (WHO) Performance Status
Subject should not have received a prior systemic anti-viral treatment for Covid19 disease.
Exclusion Criteria:
Patients with known hypersensitivity to hydroxychloroquine or chloroquine, azithromycin, erythromycin, or any other macrolide, ketolide or any of the excipients of the hydroxychloroquine and/or azithromycin-based specialty used.
Severe hepatic impairment and patients with severe cholestasis.
Patients with renal insufficiency with creatinine clearance < 40 mL/min.
Combinations of drugs contraindicated in accordance with the approvals of the specialties used.
Patients currently treated with Tamoxifen
Patients already treated by hydroxychloroquine or azithromycin for Covid19 disease or currently treated with other antiviral drugs against coronavirus.
Patients with known contra-indication to treatment with the study drug, including retinopathy, G6PD deficiency, QT prolongation and severe hepato-cellular insufficiency.
Patients post allogeneic hematopoietic stem cell transplantation are eligible to the Part B treatments but the potential toxic effects of hydroxychloroquin and azithromycin on hematopoietic stem cells should be taken into consideration by prescribers.
Pregnant or breastfeeding women. Women of childbearing potential (WOCBP, as defined in appendix 2) should have a negative urine or serum pregnancy test within 72 hours prior to receiving the first dose of study medication. If the urine test is positive or cannot be confirmed as negative, a serum pregnancy test will be required.
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Lisa DEROSA, MD
Phone
0142114211
Ext
+33
Email
lisa.derosa@gustaveroussy.fr
First Name & Middle Initial & Last Name or Official Title & Degree
Stefan MICHIELS, MD
Phone
0142114211
Ext
+33
Email
Stefan.michiels@gustaveroussy.fr
Facility Information:
Facility Name
Gustave Roussy
City
Villejuif
State/Province
Val De Marne
ZIP/Postal Code
94800
Country
France
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Lisa DEROSA, MD
Phone
0142114211
Ext
+33
Email
lisa.derosa@gustaveroussy.fr
First Name & Middle Initial & Last Name & Degree
Stefan MICHIELS, MD
Phone
0142114211
Ext
+33
Email
stefan.michiels@gustaveroussy.fr
12. IPD Sharing Statement
Plan to Share IPD
Undecided
Learn more about this trial
Epidemiology of SARS-CoV-2 and Mortality to Covid19 Disease in French Cancer Patients
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