Escitalopram Treatment of Patients With Agitated Dementia

Inclusion Criteria: Dementia of Alzheimer's type with behavioral disturbance Mild to severe cognitive impairment Age over 60 Medically stable Agitation present both at screening and baseline Agitation not responsive to simple nonpharmacologic interventions and lasting at least 2 weeks prior to enrollment. Available Health Care Proxy or other legal representative to give informed consent, and patient assent. No planned change in environment for duration of study At least one reliable caregiver Exclusion Criteria: Any intercurrent medical problem that could explain the agitation History of major depression or bipolar preceding the onset of dementia Other major psychiatric illness preceding the onset of dementia or mental retardation Other dementias History of alcohol abuse or dependence in the last 2 years Delirium (or history of delirium in the last 8 weeks) Treatment with other psychotropic drugs except those permitted in the protocol. Patients already treated for agitation with psychotropic medication must be able to successfully discontinue it and tolerate a washout period of no less than 1 week. Treatment with non-psychotropic, centrally active drugs believed to contribute to patient's agitation. Severe psychiatric symptoms requiring psychiatric hospitalization or suicidal, homicidal potential. History of intolerance to citalopram Noncompliance with oral medication or inability to take oral medication Modified Hachinski score of 4 or greater