EUS-FNB for Solid Pancreatic Lesions: Side-fenestrated Vs Fork-tip Needle
Biopsy, Fine-needle, Pancreatic Neoplasm
About this trial
This is an interventional diagnostic trial for Biopsy, Fine-needle focused on measuring pancreatic cancer, endoscopic ultrasound, fine needle biopsy
Eligibility Criteria
Inclusion Criteria:
- Solid pancreatic mass referred for EUS-guided tissue acquisition.
- Written informed consent.
Exclusion Criteria:
- Known bleeding disorder that cannot be sufficiently corrected with co-fact or fresh frozen plasma (FFP).
- Cystic lesions even with solid component.
- Previous inclusion in present study.
- Previous histological or cytological diagnosis.
- Pancreatic lesion not seen at EUS.
- Technical impossibility to perform EUS-FNB (for example, for the interposition of vessels).
- Patients in an emergency situation.
- Pregnancy or feeding time.
Sites / Locations
- Stefano Francesco Crinò
- Azienda Ospedaliera Integrata Verona
Arms of the Study
Arm 1
Arm 2
Active Comparator
Active Comparator
EUS-FNB with side-fenestrated needle
EUS-FNB with fork-tip needle
Before randomization, the endosonographer chooses the needle gauge to perform biopsy preferring the 25 gauge caliber for "difficult" lesions. The needle advances inside the lesion and the operator will perform some needle movements back and forth into the lesion while slowly withdrawn the stylet (slow-pull technique). If possible the direction of the needle inside the lesion will be changed during the movements (fanning technique) to sample different areas of the lesion. Three needle passes will be performed and the material acquired at each pass will be placed directly in formalin in a single vial. Diagnostic Test: Histologic evaluation
Intervention: like above. Diagnostic Test: Histologic evaluation.