Evaluating Skin Barrier Dysfunction in Infants at High Risk of Atopy
Atopic Dermatitis, Eczema, Food Allergy
About this trial
This is an interventional diagnostic trial for Atopic Dermatitis focused on measuring Prevention, Predictors
Eligibility Criteria
Inclusion Criteria:
- Women with physician confirmed pregnancy at a gestational age of ≥ 34 weeks. Infants at high risk for atopy will have one or both parents affected by an allergic disease. Infants at low risk for atopy will have no parent or sibling affected by allergic disease. Biologic parent(s) of infants at high risk of atopy will also be enrolled in the study.
Exclusion Criteria:
- Pregnancy loss or delivery prior to a gestational age of ≥ 34 weeks, a history of substance or alcohol abuse, psychiatric and developmental co-morbidities that would render a subject unable to provide informed consent or perform study-related procedures, AIDS and HIV infection, or a fetus with chromosomal or congenital abnormalities.
Sites / Locations
- National Jewish Health
Arms of the Study
Arm 1
Arm 2
Other
Other
High Risk Atopic Infants
Atopic Adults
Infants, who are at high risk of atopy, which will be determined by a validated questionnaire, will be enrolled. Infants will undergo skin tape stripping (STS), transepidermal water loss assessment (TEWL), bacterial swabs, and parental questionnaires at each visit (3 visits total). At the latter 2 visits, infants will also undergo skin prick testing to evaluate for food sensitization.
Parents of infants enrolled in the study will undergo skin tape stripping (STS), transepidermal water loss assessment (TEWL), and complete questionnaires at the first visit.