Back to resultsEvaluation of Antioxidant and Skin Beauty Effects of Cherry Collagen Drink
Primary Purpose
Skin Condition
Status
Completed
Phase
Not Applicable
Locations
Taiwan
Study Type
Interventional
Intervention
Cherry collagen drink
Placebo drink
Sponsored by
About this trial
This is an interventional other trial for Skin Condition
Eligibility Criteria
Inclusion Criteria:
- Healthy adults aged above 20 years old
Exclusion Criteria:
- Subject who is not willing to participate in this study.
- Patients with diseases of the skin, liver, kidney.
- Subjects who have known cosmetic, drug or food allergies, difficulty in digestive tract absorption or disorder.
- Female who is pregnant or nursing or planning to become pregnant during the course of the study.
- Received facial laser therapy, chemical peeling or UV overexposure (> 3 hr/week) in the past 4 weeks.
- Constant drug use
- Students who are currently taking courses taught by the principal investigator of this trial.
- Body weight < 50 kg.
Sites / Locations
- Chia Nan University of Pharmacy & Science
Arms of the Study
Arm 1
Arm 2
Arm Type
Placebo Comparator
Experimental
Arm Label
Placebo drink
Cherry collagen drink
Arm Description
Outcomes
Primary Outcome Measures
The change of skin wrinkles
VISIA Complexion Analysis System was utilized to measure skin wrinkles. Units: arbitrary units
The change of skin texture
VISIA Complexion Analysis System was utilized to measure skin texture. Units: arbitrary units
The change of skin collagen density
DermaLab® Series SkinLab Combo was utilized to measure skin pores. Units: arbitrary units
The change of skin elasticity
Soft Plus was utilized to measure skin elasticity. Units: arbitrary units
Secondary Outcome Measures
The change of skin melanin index
Soft Plus was utilized to measure skin melanin index. Units: arbitrary units
The change of skin L* value
Chroma Meter MM500 was utilized to measure skin L* value. Units: arbitrary units, 0-100
The change of skin moisture
Corneometer® CM825 was utilized to measure skin moisture. Units: arbitrary Corneometer® units 0-120
The change of skin spots
VISIA Complexion Analysis System was utilized to measure skin spots. Units: arbitrary units
The change of skin UV spots
VISIA Complexion Analysis System was utilized to measure skin UV spots. Units: arbitrary units
The change of skin brown spots
VISIA Complexion Analysis System was utilized to measure skin brown spots. Units: arbitrary units
The change of SOD-RBC of blood
Venous blood was sampled to measure SOD-RBC
The change of t-GSH of blood
Venous blood was sampled to measure t-GSH
The change of GST-RBC of blood
Venous blood was sampled to measure GST-RBC
The change of blood total antioxidant capacity (TAC)
Venous blood was sampled to measure concentrations of TAC
The change of desmosine of blood
Venous blood was sampled to measure concentrations of desmosine
The change of TNF-alpha of blood
Venous blood was sampled to measure concentrations of TNF-alpha
The change of transepidermal water loss (TEWL)
Tewameter® TM300 was utilized to measure TEWL. Units: g/hm²
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT05376657
Brief Title
Evaluation of Antioxidant and Skin Beauty Effects of Cherry Collagen Drink
Official Title
Evaluation of Antioxidant and Skin Beauty Effects of Cherry Collagen Drink
Study Type
Interventional
2. Study Status
Record Verification Date
September 2022
Overall Recruitment Status
Completed
Study Start Date
April 1, 2022 (Actual)
Primary Completion Date
July 20, 2022 (Actual)
Study Completion Date
September 3, 2022 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
TCI Co., Ltd.
4. Oversight
Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
5. Study Description
Brief Summary
To assess cherry collagen drink on skin condition improvement
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Skin Condition
7. Study Design
Primary Purpose
Other
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
ParticipantInvestigator
Allocation
Randomized
Enrollment
60 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Placebo drink
Arm Type
Placebo Comparator
Arm Title
Cherry collagen drink
Arm Type
Experimental
Intervention Type
Dietary Supplement
Intervention Name(s)
Cherry collagen drink
Other Intervention Name(s)
YOUNIQUE DAILY YOU liquid collagen shot
Intervention Description
consume 1 sachet per day
Intervention Type
Dietary Supplement
Intervention Name(s)
Placebo drink
Intervention Description
consume 1 sachet per day
Primary Outcome Measure Information:
Title
The change of skin wrinkles
Description
VISIA Complexion Analysis System was utilized to measure skin wrinkles. Units: arbitrary units
Time Frame
Change from Baseline skin wrinkles at 8 weeks
Title
The change of skin texture
Description
VISIA Complexion Analysis System was utilized to measure skin texture. Units: arbitrary units
Time Frame
Change from Baseline skin texture at 8 weeks
Title
The change of skin collagen density
Description
DermaLab® Series SkinLab Combo was utilized to measure skin pores. Units: arbitrary units
Time Frame
Change from Baseline skin collagen density at 8 weeks
Title
The change of skin elasticity
Description
Soft Plus was utilized to measure skin elasticity. Units: arbitrary units
Time Frame
Change from Baseline skin elasticity at 8 weeks
Secondary Outcome Measure Information:
Title
The change of skin melanin index
Description
Soft Plus was utilized to measure skin melanin index. Units: arbitrary units
Time Frame
Change from Baseline skin melanin index at 8 weeks
Title
The change of skin L* value
Description
Chroma Meter MM500 was utilized to measure skin L* value. Units: arbitrary units, 0-100
Time Frame
Change from Baseline L* value at 8 weeks
Title
The change of skin moisture
Description
Corneometer® CM825 was utilized to measure skin moisture. Units: arbitrary Corneometer® units 0-120
Time Frame
Change from Baseline skin moisture at 8 weeks
Title
The change of skin spots
Description
VISIA Complexion Analysis System was utilized to measure skin spots. Units: arbitrary units
Time Frame
Change from Baseline skin spots at 8 weeks
Title
The change of skin UV spots
Description
VISIA Complexion Analysis System was utilized to measure skin UV spots. Units: arbitrary units
Time Frame
Change from Baseline skin UV spots at 8 weeks
Title
The change of skin brown spots
Description
VISIA Complexion Analysis System was utilized to measure skin brown spots. Units: arbitrary units
Time Frame
Change from Baseline skin brown spots at 8 weeks
Title
The change of SOD-RBC of blood
Description
Venous blood was sampled to measure SOD-RBC
Time Frame
Change from Baseline SOD-RBC at 8 weeks
Title
The change of t-GSH of blood
Description
Venous blood was sampled to measure t-GSH
Time Frame
Change from Baseline t-GSH at 8 weeks
Title
The change of GST-RBC of blood
Description
Venous blood was sampled to measure GST-RBC
Time Frame
Change from Baseline GST-RBC at 8 weeks
Title
The change of blood total antioxidant capacity (TAC)
Description
Venous blood was sampled to measure concentrations of TAC
Time Frame
Change from Baseline TAC at 8 weeks
Title
The change of desmosine of blood
Description
Venous blood was sampled to measure concentrations of desmosine
Time Frame
Change from Baseline desmosine at 8 weeks
Title
The change of TNF-alpha of blood
Description
Venous blood was sampled to measure concentrations of TNF-alpha
Time Frame
Change from Baseline TNF-alpha at 8 weeks
Title
The change of transepidermal water loss (TEWL)
Description
Tewameter® TM300 was utilized to measure TEWL. Units: g/hm²
Time Frame
Change from Baseline TEWL at 8 weeks
Other Pre-specified Outcome Measures:
Title
The change of liver function biomarkers (AST, ALT) of blood
Description
Venous blood was sampled to measure liver function biomarkers
Time Frame
Change from Baseline liver function biomarkers at 8 weeks
Title
The change of renal function biomarkers (creatinine, BUN) of blood
Description
Venous blood was sampled to measure renal function biomarkers
Time Frame
Change from Baseline renal function biomarkers at 8 weeks
Title
The change of self-assessment skin condition
Description
A self-assessment questionnaire was collected to evaluate skin condition
Time Frame
Change from Baseline skin condition at 8 weeks
10. Eligibility
Sex
All
Minimum Age & Unit of Time
20 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
Healthy adults aged above 20 years old
Exclusion Criteria:
Subject who is not willing to participate in this study.
Patients with diseases of the skin, liver, kidney.
Subjects who have known cosmetic, drug or food allergies, difficulty in digestive tract absorption or disorder.
Female who is pregnant or nursing or planning to become pregnant during the course of the study.
Received facial laser therapy, chemical peeling or UV overexposure (> 3 hr/week) in the past 4 weeks.
Constant drug use
Students who are currently taking courses taught by the principal investigator of this trial.
Body weight < 50 kg.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Chia-Hua Liang
Organizational Affiliation
Chia Nan University of Pharmacy ＆ Science
Official's Role
Principal Investigator
Facility Information:
Facility Name
Chia Nan University of Pharmacy & Science
City
Tainan City
ZIP/Postal Code
71710
Country
Taiwan
12. IPD Sharing Statement
Learn more about this trial
Evaluation of Antioxidant and Skin Beauty Effects of Cherry Collagen Drink
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