Evaluation of CTCA in Assessing Plaque Pathology and Physiology
Coronary Artery Disease
About this trial
This is an interventional diagnostic trial for Coronary Artery Disease focused on measuring Near Infrared Spectroscopy, Computed Tomography Coronary Angiography, Atherosclerosis, Endothelial Shear Stress
Eligibility Criteria
Inclusion Criteria:
Patients with typical angina symptoms who had elective coronary angiography showing at least one lesion that requires further evaluation with intravascular coronary imaging or fractional flow reserve or it is considered suitable for percutaneous coronary intervention (PCI) under IVUS guidance will be included in the study
Exclusion Criteria:
- age >75 years
- ACS within <3 months
- eGFR <60ml/min/1.73m²
- previous coronary artery bypass surgery
- decompensated heart failure, or left ventricular ejection fraction ≤30%
- intravenous contrast allergy or inability to receive treatment with aspirin, heparin, or thienopyridines
- anticipated life expectancy <1 year
- history of heart transplantation
- patient that requires surgical revascularization
- extensive coronary artery disease (i.e., multiple chronic total occlusions) or tortuous coronary anatomy that does not allow assessment of the coronary arteries with NIRS-IVUS imaging
Sites / Locations
- Barts Health NHS Trust
Arms of the Study
Arm 1
Other
Single arm study
70 patients with coronary artery disease will have CTCA imaging and 3 vessel intravascular imaging with NIRS-IVUS during percutaneous coronary intervention and the obtained imaging data will be used to assess the efficacy of CTCA in detecting plaque morphology and shear stress distribution.