Evaluation of Emerging New Treatments for Infection Prevention in Total Joint Replacement (PREVENT-IT)
Periprosthetic Joint Infection, Draining Wound
About this trial
This is an interventional prevention trial for Periprosthetic Joint Infection
Eligibility Criteria
Inclusion Criteria:
- Patients 18 years of age or older.
- Undergoing primary or revision TJR.
- Informed consent obtained.
Exclusion Criteria:
- Received antibiotics for any reason in the two weeks prior to their TJR.
- Chronic or acute infection at or near the TJR site.
- Prior history of PJI.
- Undergoing surgery for a diagnosis of a fracture.
- Open wounds on affected limb.
- Undergoing bilateral TJR.
- Medical contraindication to povidone-iodine.
- Medical contraindication to chlorhexidine.
- Medical contraindication to vancomycin.
- Current or anticipated incarceration.
- Terminal illness with expected survival less than 90 days.
- Currently enrolled in a study that does not permit co-enrollment.
- Unable to obtain informed consent due to language barriers.
- Problems, in the judgment of study personnel, with maintaining follow-up with the patient.
- Prior enrollment in the trial.
- Other reason to exclude the patient, as approved by the Methods Centre.
Sites / Locations
- St. Joseph's Healthcare
- Hamilton Health Sciences- Juravinkski Hospital
- Montreal General Hospital
- St. Mary's Hospital
- Hospital Clinic Barcelona
- Vall d'Hebron University HospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Experimental
Experimental
Experimental
Experimental
Experimental
Active Comparator
Povidone-iodine Lavage and Local Antibiotics
Chlorhexidine Lavage and Local Antibiotics
Normal Saline Lavage and Local Antibiotics
Povidone-iodine Lavage Solution with no Local Antibiotics
Chlorhexidine Lavage Solution with no Local Antibiotics
Normal Saline Lavage with no Local Antibiotics
1 litre of 0.35% povidone-iodine lavage solution will be used. 2 grams of Vancomycin antibiotic powder will be applied to the deep joint (deep to fascia) following lavage solution and immediately prior to closure.
1 litre of 0.05% chlorhexidine lavage solution will be used. 2 grams of Vancomycin antibiotic powder will be applied to the deep joint (deep to fascia) following lavage solution and immediately prior to closure.
1 litre of sterile isotonic saline solution will be used. 2 grams of Vancomycin antibiotic powder will be applied to the deep joint (deep to fascia) following lavage solution and immediately prior to closure.
1 litre of 0.35% povidone-iodine lavage solution will be used immediately prior to closure.
1 litre of 0.05% chlorhexidine lavage solution will be used immediately prior to closure.
1 litre of sterile isotonic saline solution will be used immediately prior to closure.