Evaluation of Fructose Ingestion and the Renin Angiotensin System in Humans
Chronic Kidney Disease
About this trial
This is an interventional other trial for Chronic Kidney Disease focused on measuring human, fructose, dextrose, renin angiotensin system, kidney, renal hemodynamics
Eligibility Criteria
Inclusion Criteria:
- age≥18 years,
- able to comprehend study and comply with high-salt diet
- kidney disease (on the approval of their nephrologist)
- on an oral birth control pill and non oral birth control and those not on birth control
Exclusion Criteria:
- cardiovascular disease (symptoms consistent with myocardial ischemia, previously documented myocardial ischemia, cardiac arrhythmias or valve abnormalities, or abnormal ECG at screening)
- cerebrovascular disease (transient ischemic attacks or stroke)
- hypertension (BP>140/90 or use of antihypertensive medications)
- diabetes mellitus (defined by history, use of hypoglycemic agents or a fasting glucose >7mmol/L)
- hyperlipidemia (LDL >4.5mmol/L or use of lipid-lowering agents)
- pregnancy
Sites / Locations
- University of Calgary
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Fructose First
Dextrose First
Study Day 1 - measurement of renal hemodynamics and blood pressure Subjects will ingest fructose 200g daily x 14d Study Day 2 - measurement of renal hemodynamics Minimum 1 week "washout" period Subjects will ingest dextrose 200g daily x 14d Study Day 3 - measurement of renal hemodynamics and blood pressure
Study Day 1 - measurement of renal hemodynamics and blood pressure Subjects will ingest dextrose 200g daily x 14d Study Day 2 - measurement of renal hemodynamics Minimum 1 week "washout" period Subjects will ingest fructose 200g daily x 14d Study Day 3 - measurement of renal hemodynamics and blood pressure