Evaluation of Intravenous Levosimendan Efficacy in the Short Term Treatment of Decompensated Chronic Heart Failure.
Heart Failure, Congestive
About this trial
This is an interventional treatment trial for Heart Failure, Congestive focused on measuring Decompensated chronic heart failure
Eligibility Criteria
Inclusion Criteria: A written informed consent must be obtained for hospitalized male or female patients over 18 years old of age. The eligible patients must be diagnosed with worsening heart failure as evidenced by dyspnea at rest, poor ejection fraction and have been treated with IV diuretics. It is allowable for the patients to be treated with IV inotropes and vasodilators. Exclusion Criteria: The following criteria would exclude the patient from study: invasive cardiac procedure (e.g. cardiac surgery, LVAD, cardioversion, cardiac re-synchronization), rhythm disorders (e.g. earlier Torsades de Pointes, increased heart rate), severe ventricular outflow obstruction, angina, hypotension, uncorrected hypokalemia, CNS (e.g. stroke, TIA), respiratory (e.g. COPD, intubated patients, oral, intravenous or intramuscular steroids), renal insufficiency (e.g. increased serum creatinine, dialysis), hepatic impairment (e.g. significant increase in liver enzymes), decompensation from active infection and acute bleeding (e.g. severe anemia). Female patients of child bearing potential must have a negative pregnancy test and use adequate contraceptive precautions. Also excluded is the use of amrinone and milrinone prior to randomization, a history of hypersensitivity to levosimendan or any of the excipients and previous participation in a clinical trial with any experimental treatment within the last 30 days.
Sites / Locations
- Cardiovascular Associates/Office of Clinical Research
- Cardiology, P.C. Research
- University Alabama at Birmingham
- Oracle Research-The Heart Center
- Providence Hospital Heart Failure Clinic
- Arizona Heart Institute
- Sarver Heart Center - University of Arizona Health Science
- Central Arkansas Veterans Healthcare System
- University of Arkansas for Medical Sciences
- Central Cardiology Medical Center
- Cardiovascular Medical Group & Research Institute
- San Diego Cardiovascular Research
- Apex Cardiology Consultants, Inc.
- Loma Linda University Medical Center
- Los Angeles County/USC Medical Center
- Cedars-Sinai Medical Center
- VA Greater Los Angeles Healthcare System
- Merced Heart Associates
- A.R.I. Clinical Trials, Inc.
- Sacramento Heart and Vascular Research Center
- UCSD Medical Center, University of California
- San Diego Cardiac Center
- VA San Diego Healthcare System
- VA Hospital of San Francisco
- Denver Health Medical Center
- University of Connecticut Health Center
- Yale University School of Medicine/Heart Failure Center
- Hospital of Saint Raphael
- Christiana Care Health System
- Washington Hospital Center - Cardiac Surgery Department
- George Washington University
- University of Florida
- Jacksonville Heart Center PA-Baptist Office
- Jacksonville Heart Center,PA
- Watson Clinic Center for Research
- MIMA Century Research Associates
- Jackson Memorial Hospital
- Miami Research & Education Foundation
- The Ford Research Institute PA/NW Florida Heart Group PA
- Victor Howard M.D., P.A. Heart Research Center
- Heart & Vascular Institute of Florida
- Florida Cardiovascular Institute
- Augusta Cardiology Clinic, P.C.
- Memorial Health University Medical Center Research Center
- Northwestern Memorial Hospital/Heart Failure Program
- Rush-Presbyterian-St. Luke's Medical Center
- Elgin Cardiology Associates
- Midwest Heart Research Foundation
- Heart Care Midwest
- Clarian Health - Methodist Research Institute Inc.
- Iowa Heart Center
- University Hospital, Iowa City
- Via Christi Research Inc. dba PriVia
- Gill Heart Institute/University of Kentucky
- Louisiana Heart Center
- New Orleans Clinical Trial Management, Inc.
- Tulane University Health Sciences Center
- Cardiac Centers of Louisiana, LLC
- Medical Research Institute
- University of Maryland Hospital
- John Hopkins Bayview Medical Center
- The Johns Hopkins Hospital
- Boston Medical Center
- Baystate Medical Center
- University of Michigan Medical Center, CACR
- Wayne State University
- Henry Ford Health System
- Nisus Research/Northern Michigan Hospital
- William Beaumont Hospital
- Michigan Heart P.C.
- Hennepin County Medical Center
- VA Medical Center - Cardiology Department
- University of Minnesota
- St. Paul Clinic
- University Hospitals Clinic
- Saint Louis University Hospital
- International Heart Institute Montana Foundation
- Alegent Health Heart and Vascular Institute
- The Creighton Cardiac Center
- Dartmouth-Hitchcock Medical Center
- Hackensack University Medical Center
- Heart Failure & Transplantation Program
- Heart Hospital of New Mexico - NW Heart Institute
- Jack D. Weiler Hospital/Albert Einstein Hospital
- Montefiore Medical Center/Cardiology Department
- Beth Israel Medical Center NY/Phillips Ambulatory Care Center
- St. Vincent's Hospital
- Columbia-Presbyterian Medical Center
- University Of North Carolina
- The Lindner Center
- University of Cincinnati Medical Center
- University Hospitals of Cleveland
- Cleveland Clinic Foundation/Department of Cardiology
- OSU Medical Center-Center Wellness & Prevention
- The Toledo Clinic & Outpatient Surgery
- Toledo Clinic & Outpatient Surgery/Department of Cardiology
- Oklahoma Foundation-Cardiovascular
- University Health Science Center/Cardio Section
- Hillsboro Cardiology, PC
- Oregon Health & Science University
- Providence Portland Medical Center/Heart Failure Clinic
- Geisinger Health System
- The Milton S. Hershey Medical Center
- Heart Group
- Hahnemann University Hospital/HF and Transplant Center
- Universtiy of PA Health System
- Jefferson Heart Institute
- University of Pittsburgh
- Buxmont Cardiology Associates
- Cardiology Associates of West Reading
- Rhode Island Hospital/University Cardiology
- Baptist Clinical Research Center
- Cardiology Group, P.C.
- Austin-Cardiovascular Associates
- Dallas VA Medical Center
- Cardiopulmonary Research Science & Technology Institute
- Cardiovascular Research Institute of Dallas
- Baylor College of Medicine
- Houston VA Medical Center
- St. Luke's Episcopal Hospital/Texas Heart Institute
- Heart Specialists
- University of Texas Health Sciences
- UTHCT/Center for Clinical Research
- Sentara Norfolk General Hospital
- Carilion Department of Clinical Research
- DUCCS Research of South Boston
- Overlake Hospital Medical Center
- University of Washington
- Inland Cardiology Associates
- Southwest Washington Medical Center
- Beloit Clinic, SC
- St. Luke's Medical Center
- Canberra Hospital/Cardiology Department
- Royal Prince Alfred Hospital/Department of Cardiology
- Concord Hospital - Heart Failure Clinic/Department of Cardiology
- Gosford Hospital
- Liverpool Hospital - Cardiology Research
- Prince of Wales Hospital
- Royal North Shore Hospital - Cardiology Department
- St. George Hospital/Cardiology Department
- Royal Brisbane Hospital - Cardiology Department
- The Princess Alexandra Hospital
- Flinders Medical Centre - Cardiac Research Department
- Queen Elizabeth Hospital/Cardiology Department
- Royal Hobart Hospital
- Launceston General Hospital/Cardiac Research Unit
- Box Hill Hospital - Coronary Care Unit
- St. Vincent's Hospital - Cardiology Investigational Unit
- Karinia House/Geelong Hospital
- Level 2, Cardiology Department/Royal Melbourne Hospital
- Heart Research Institute/Sir Charles Gairdner Hospital
- University of Calgary
- Rockyview Hospital, Heart Health Institute
- University of Alberta Hospitals
- University of Ottawa Health Institute
- Neureka Research, Willet Green Niller Centre
- Center Hospital University of Sherbrooke
- University of Saskatchewan
- Barzilai Medical Center
- Hillel Yaffe Medical Center
- Wolfson Medical Center
- Heart Institute, Hadassah MC
- EMMS Nazareth Hospital
- Kaplan Medical Center
- Sieff Medical Center
- Assaf Harofe Medical Center