Evaluation of the Effect of Repetitive Transcranial Magnetic Stimulation in Pain Perception in Parkinson's Disease (rTMS)
Parkinson's Disease
About this trial
This is an interventional basic science trial for Parkinson's Disease focused on measuring Repetitive Transcranial Magnetic Stimulation, pain threshold, Parkinson's disease, Pain threshold in Parkinson's disease
Eligibility Criteria
Inclusion Criteria:
For patients:
- Patients with clinical diagnosis of Parkinson's disease according to the criteria of the UKPDSBB
- Parkinson's disease patients with a score≤3 on the Hoehn and Year scale
- Patients treated with dopaminergic antiparkinsonian drugs (L-DOPA, dopamine agonists,ICOMT…)
- Patients with or without neuropathic pain induced by Parkinson's disease
- Patients without personal or familial epilepsy episode history
- Patients from 50 to 80 years old (male or female)
- Patients affiliated to a social protection program
- Patient with an informed consent given
For Healthy volunteers
- Subjects from 50 to 80 years old (male or female)
- Subjects without any serious evolutionary pathology or any clinical significant treatment
- Subjects without chronic pain or disease which can induce neuropathic pain
- Subjects without personal or familial epilepsy episode history
- Subjects affiliated to a social protection program
- Subjects with an informed consent given
Exclusion Criteria:
For patients:
- Patients suffering from an other pathology causing chronic pain (rheumatic disease, traumatic or orthopaedic pathologies…)
- Parkinson's disease patients with a score>3 on the Hoehn and Yahr scale
- Patients with important tremors during a OFF conditions
- Patients suffering from a cancer
- Patients with a neuroleptic treatment
- Patients under tutelage, curatella or law protection
- Patients included in an other clinical study
- Patients unable to fulfil scales of the study
- Patients with personal or familial epilepsy episode history
- Contraindication of IRM
- Pregnant women
For Healthy volunteers:
- Subjects with serious evolutionary pathology or any clinical significant treatment
- Subjects with chronic pain or disease which can induce neuropathic pain
- Subjects with personal or familial epilepsy episode history
- Contraindication of IRM
- Pregnant women
- Subjects under tutelage, curatella or law protection
- Subjects included in an other clinical study
Sites / Locations
- Purpan Hospital
Arms of the Study
Arm 1
Arm 2
Arm 3
Other
Other
Other
healthy volunteers
painful Parkinson's disease patients
painless Parkinson's disease patients
All the patients and healthy volunteers will receive high frequency Repetitive Transcranial Magnetic Stimulation and placebo stimulation
All the patients and healthy volunteers will receive high frequency Repetitive Transcranial Magnetic Stimulation and placebo stimulation
All the patients and healthy volunteers will receive high frequency Repetitive Transcranial Magnetic Stimulation and placebo stimulation