Evaluation of the Efficacy of 3M Dry Mouth Moisturizing Spray
Primary Purpose
Xerostomia
Status
Completed
Phase
Not Applicable
Locations
United States
Study Type
Interventional
Intervention
3M Dry Mouth Moisturizing Spray to Biotene Moisturizing Mouth Spray
Biotene Moisturizing Mouth Spray to 3M Dry Mouth Moisturizing Spray
Sponsored by
About this trial
This is an interventional treatment trial for Xerostomia
Eligibility Criteria
Inclusion Criteria:
Screening - Start of Wash-In Visit
- Subject who is ≥18 years of age and complains of dry mouth
- Only 1 subject per household is allowed into study
- Subject with a Challacombe scale score of 1 or higher
- Subject agrees to refrain from eating spicy foods and foods containing garlic beginning 48-hours prior to all study visits
- Subject agrees to eat a meal prior to all study visits that include sample evaluation in the clinic
- Subject agrees to not eat, drink, chew tobacco, chew gum, smoke, brush or floss teeth for 2-hours prior to sample evaluation study visits
- Subject agree to not use any oral care products and any type of breath mint or lozenges for 2-hours prior to sample evaluation study visits
- Subject agrees to refrain from any food and liquid during the 5-hour study visits except for what is provided by the study research staff (e.g., water and treatments A and B during evaluation periods)
- Subject agrees to only use those clinical oral care supplies provided during the entire study
- Able to understand and willing to sign the Informed Consent Form
Water Only Evaluation Visit
- Subject has successfully completed a ≥ 2-day wash-in period
- Subject has Challacombe scale score of 1 or higher
- Subject has refrained from eating spicy foods and foods containing garlic beginning 48-hours prior to the sample evaluation visits
- Subject ate a meal prior to sample evaluation study visits
- Subject has not eaten, drank, chewed tobacco, chewed gum, smoked, brushed or flossed teeth for 2-hours prior to sample evaluation study visits
- Subject has not used any oral care products, any type of breath mint or lozenges for 2-hours prior to sample evaluation study visits
- Subject agrees to refrain from any food and liquid during the 5-hour study visits except for what is provided by the study research staff (e.g., water and treatments A and B during evaluation periods)
- Subject has used only those clinical oral care supplies provided during study
Baseline Period 1/Randomization Visit
- Subject has successfully completed a ≥ 2-day wash-in period
- Subject has a Challacombe Scale score of 1 or higher
- Subject has refrained from eating spicy foods and foods containing garlic beginning 48-hours prior to sample evaluation study visits
- Subject ate a meal prior to sample evaluation study visits
- Subject has not eaten, drank, chewed tobacco, chewed gum, smoked, brushed or flossed teeth for 2-hours prior to sample evaluation study visits
- Subject has not used any oral care products and any type of breath mint or lozenges for 2-hours prior to sample evaluation study visits
- Subject agrees to refrain from any food and liquid during the 5-hour study visits except for what is provided by the study research staff (e.g., water and treatments A and B during evaluation periods)
- Subject has used only those clinical oral care supplies provided during study
Exclusion Criteria:
Subject Exclusion Criteria for Start of Wash-In, Water Only Evaluation and Baseline Period 1 (Randomization Visit)
- Subject has active mouth sores (e.g., cold sores, cuts, burns, canker sores)
- Subject has a life-threatening pathological condition
- Subject is participating in another clinical trial at the time of the study
- Subject has profound marginal periodontal disease (purulent exudate, tooth mobility, and/or extensive alveolar bone loss)
- Medical and oral conditions that, in the investigator's judgment, may compromise the subject's safety or interfere with the conduct and outcome of the study
- Difficult to be compliant with recalls, such as extensive travel commitments, lack of transportation etc.
Sites / Locations
- Loma Linda University, School of Dentistry
Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Active Comparator
Arm Label
3M Dry Mouth Moisturizing Spray
Biotene Moisturizing Mouth Spray
Arm Description
Dry mouth agent
Dry mouth agent
Outcomes
Primary Outcome Measures
10 cm Mouth Dryness Visual Analog Score
Primary endpoint will be paired-difference in Visual Analog Scale (VAS) between experimental and active control product. On the scale 0 represents normal and 10 represents worst imaginable dry mouth symptoms.
Secondary Outcome Measures
10 cm Mean Mouth Dryness Visual Analog Score
Mean Visual Analog Scale (VAS) on the scale 0 represents normal and 10 represents worst imaginable dry mouth symptoms
10 cm Mouth Dryness Visual Analog Score
Paired-difference Visual Analog Scale (VAS) between both experimental and active control against water control. The range of possible values is -10 to +10. A negative value means is a better outcome than water. A positive value means is a worse outcome than water.
10 cm Mean Mouth Dryness Visual Analog Score
Mean Visual Analog Scale (VAS) on the scale 0 represents normal and 10 represents worst imaginable dry mouth symptoms
10 cm Mean Mouth Dryness Visual Analog Scale
Mean Visual Analog Scale (VAS) on the scale 0 represents normal and 10 represents worst imaginable dry mouth symptoms
10 cm Mean Mouth Dryness Visual Analog Scale
Mean Visual Analog Scale (VAS) on the scale 0 represents normal and 10 represents worst imaginable dry mouth symptoms
10 cm Mean Mouth Dryness Visual Analog Scale
Mean Visual Analog Scale (VAS) on the scale 0 represents normal and 10 represents worst imaginable dry mouth symptoms
10 cm Mouth Dryness Visual Analog Scale
Paired-difference Visual Analog Scale (VAS) between both experimental and active control against water control. The range of possible values is -10 to +10. A negative value means is a better outcome than water. A positive value means is a worse outcome than water.
10 cm Mouth Dryness Visual Analog Scale
Paired-difference Visual Analog Scale (VAS) between both experimental and active control against water control. The range of possible values is -10 to +10. A negative value means is a better outcome than water. A positive value means is a worse outcome than water.
10 cm Mouth Dryness Visual Analog Scale
Paired-difference Visual Analog Scale (VAS) between both experimental and active control against water control. The range of possible values is -10 to +10. A negative value means is a better outcome than water. A positive value means is a worse outcome than water.
10 cm Mouth Dryness Visual Analog Score
Paired-difference Visual Analog Scale (VAS) between both experimental and active control against water control. The range of possible values is -10 to +10. A negative value means is a better outcome than water. A positive value means is a worse outcome than water.
10 cm Mouth Dryness Visual Analog Score
Paired-difference Visual Analog Scale (VAS) between both experimental and active control against water control. The range of possible values is -10 to +10. A negative value means is a better outcome than water. A positive value means is a worse outcome than water.
Response on Dry Mouth Relief
Count of each category of the ordinal scale 0 = No Relief and 4 = Significant/Excellent
Response on Dry Mouth Relief
Count of each category of the ordinal scale 0 = No Relief and 4 = Significant/Excellent
Response on Dry Mouth Relief
Count of each category of the ordinal scale 0 = No Relief and 4 = Significant/Excellent
Response on Dry Mouth Relief
Count of each category of the ordinal scale 0 = No Relief and 4 = Significant/Excellent
Response on Dry Mouth Relief
Count of each category of the ordinal scale 0 = No Relief and 4 = Significant/Excellent
Response on Dry Mouth Relief
Count of each category of the ordinal scale 0 = No Relief and 4 = Significant/Excellent
Response to Effectively Lubricates the Mouth
5 point ordinal scale 1 = Poor and 5 = Excellent
Response to Effectively Lubricates the Mouth
5 point ordinal scale 1 = Poor and 5 = Excellent
Response to Effectively Lubricates the Mouth
5 point ordinal scale 1 = Poor and 5 = Excellent
Response to Effectively Lubricates the Mouth
5 point ordinal scale 1 = Poor and 5 = Excellent
Response to Effectively Lubricates the Mouth
5 point ordinal scale 1 = Poor and 5 = Excellent
Response to Effectively Lubricates the Mouth
5 point ordinal scale 1 = Poor and 5 = Excellent
Response to Feel Comfortable in the Mouth
5 point ordinal scale 1 = Poor and 5 = Excellent
Response to Feel Comfortable in the Mouth
5 point ordinal scale 1 = Poor and 5 = Excellent
Response to Feel Comfortable in the Mouth
5 point ordinal scale 1 = Poor and 5 = Excellent
Response to Feel Comfortable in the Mouth
5 point ordinal scale 1 = Poor and 5 = Excellent
Response to Feel Comfortable in the Mouth
5 point ordinal scale 1 = Poor and 5 = Excellent
Response to Feel Comfortable in the Mouth
5 point ordinal scale 1 = Poor and 5 = Excellent
Response to Soothing in the Mouth
5 point ordinal scale 1 = Poor and 5 = Excellent
Response to Soothing in the Mouth
5 point ordinal scale 1 = Poor and 5 = Excellent
Response to Soothing in the Mouth
5 point ordinal scale 1 = Poor and 5 = Excellent
Response to Soothing in the Mouth
5 point ordinal scale 1 = Poor and 5 = Excellent
Response to Soothing in the Mouth
5 point ordinal scale 1 = Poor and 5 = Excellent
Response to Soothing in the Mouth
5 point ordinal scale 1 = Poor and 5 = Excellent
Response to Effectively Moistens the Mouth
5 point ordinal scale 1 = Poor and 5 = Excellent
Response to Effectively Moistens the Mouth
5 point ordinal scale 1 = Poor and 5 = Excellent
Response to Effectively Moistens the Mouth
5 point ordinal scale 1 = Poor and 5 = Excellent
Response to Effectively Moistens the Mouth
5 point ordinal scale 1 = Poor and 5 = Excellent
Response to Effectively Moistens the Mouth
5 point ordinal scale 1 = Poor and 5 = Excellent
Response to Effectively Moistens the Mouth
5 point ordinal scale 1 = Poor and 5 = Excellent
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT04186806
Brief Title
Evaluation of the Efficacy of 3M Dry Mouth Moisturizing Spray
Official Title
An Evaluation of the Efficacy of 3M Dry Mouth Moisturizing Spray on the Relief of Dry Mouth Symptoms
Study Type
Interventional
2. Study Status
Record Verification Date
November 2020
Overall Recruitment Status
Completed
Study Start Date
November 2, 2019 (Actual)
Primary Completion Date
December 13, 2019 (Actual)
Study Completion Date
December 13, 2019 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
3M
4. Oversight
Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
Yes
Device Product Not Approved or Cleared by U.S. FDA
Yes
Product Manufactured in and Exported from the U.S.
No
Data Monitoring Committee
No
5. Study Description
Brief Summary
The purpose of the clinical trial is to evaluate and validate the performance of the experimental mouth spray when used by persons with mild to severe dry mouth symptoms.
Detailed Description
The purpose of this study is to investigate the efficacy of 3M Dry Mouth Moisturizing Spray to reduce symptoms of dry mouth for up to 4 hours and after 7 days of use. In addition, this study aims to support comparative claims.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Xerostomia
7. Study Design
Primary Purpose
Treatment
Study Phase
Not Applicable
Interventional Study Model
Crossover Assignment
Model Description
All subjects completing the wash-in procedures and meeting inclusion/exclusion criteria will undergo a pre-study 5-hour visit (the day before randomization) to assess the effect of water on their dry mouth symptoms. The subjects will return the next day for confirmation that inclusion/exclusion criteria and the wash-in procedures continue to be met or followed. Eligible subjects will be randomized at this baseline visit in a 1:1 ratio to one of two treatment orders: A->B (AB) or B->A (BA).
Masking
Outcomes Assessor
Allocation
Randomized
Enrollment
40 (Actual)
8. Arms, Groups, and Interventions
Arm Title
3M Dry Mouth Moisturizing Spray
Arm Type
Experimental
Arm Description
Dry mouth agent
Arm Title
Biotene Moisturizing Mouth Spray
Arm Type
Active Comparator
Arm Description
Dry mouth agent
Intervention Type
Device
Intervention Name(s)
3M Dry Mouth Moisturizing Spray to Biotene Moisturizing Mouth Spray
Intervention Description
20 ml bottle
Intervention Type
Device
Intervention Name(s)
Biotene Moisturizing Mouth Spray to 3M Dry Mouth Moisturizing Spray
Intervention Description
44.3 ml bottle
Primary Outcome Measure Information:
Title
10 cm Mouth Dryness Visual Analog Score
Description
Primary endpoint will be paired-difference in Visual Analog Scale (VAS) between experimental and active control product. On the scale 0 represents normal and 10 represents worst imaginable dry mouth symptoms.
Time Frame
15 minutes post dose
Secondary Outcome Measure Information:
Title
10 cm Mean Mouth Dryness Visual Analog Score
Description
Mean Visual Analog Scale (VAS) on the scale 0 represents normal and 10 represents worst imaginable dry mouth symptoms
Time Frame
240 minutes post dose
Title
10 cm Mouth Dryness Visual Analog Score
Description
Paired-difference Visual Analog Scale (VAS) between both experimental and active control against water control. The range of possible values is -10 to +10. A negative value means is a better outcome than water. A positive value means is a worse outcome than water.
Time Frame
240 minutes
Title
10 cm Mean Mouth Dryness Visual Analog Score
Description
Mean Visual Analog Scale (VAS) on the scale 0 represents normal and 10 represents worst imaginable dry mouth symptoms
Time Frame
5 minutes
Title
10 cm Mean Mouth Dryness Visual Analog Scale
Description
Mean Visual Analog Scale (VAS) on the scale 0 represents normal and 10 represents worst imaginable dry mouth symptoms
Time Frame
30 minutes
Title
10 cm Mean Mouth Dryness Visual Analog Scale
Description
Mean Visual Analog Scale (VAS) on the scale 0 represents normal and 10 represents worst imaginable dry mouth symptoms
Time Frame
60 minutes
Title
10 cm Mean Mouth Dryness Visual Analog Scale
Description
Mean Visual Analog Scale (VAS) on the scale 0 represents normal and 10 represents worst imaginable dry mouth symptoms
Time Frame
120 minutes
Title
10 cm Mouth Dryness Visual Analog Scale
Description
Paired-difference Visual Analog Scale (VAS) between both experimental and active control against water control. The range of possible values is -10 to +10. A negative value means is a better outcome than water. A positive value means is a worse outcome than water.
Time Frame
5 minutes
Title
10 cm Mouth Dryness Visual Analog Scale
Description
Paired-difference Visual Analog Scale (VAS) between both experimental and active control against water control. The range of possible values is -10 to +10. A negative value means is a better outcome than water. A positive value means is a worse outcome than water.
Time Frame
15 minutes
Title
10 cm Mouth Dryness Visual Analog Scale
Description
Paired-difference Visual Analog Scale (VAS) between both experimental and active control against water control. The range of possible values is -10 to +10. A negative value means is a better outcome than water. A positive value means is a worse outcome than water.
Time Frame
30 minutes
Title
10 cm Mouth Dryness Visual Analog Score
Description
Paired-difference Visual Analog Scale (VAS) between both experimental and active control against water control. The range of possible values is -10 to +10. A negative value means is a better outcome than water. A positive value means is a worse outcome than water.
Time Frame
60 minutes
Title
10 cm Mouth Dryness Visual Analog Score
Description
Paired-difference Visual Analog Scale (VAS) between both experimental and active control against water control. The range of possible values is -10 to +10. A negative value means is a better outcome than water. A positive value means is a worse outcome than water.
Time Frame
120 minutes
Title
Response on Dry Mouth Relief
Description
Count of each category of the ordinal scale 0 = No Relief and 4 = Significant/Excellent
Time Frame
5 minutes
Title
Response on Dry Mouth Relief
Description
Count of each category of the ordinal scale 0 = No Relief and 4 = Significant/Excellent
Time Frame
15 minutes
Title
Response on Dry Mouth Relief
Description
Count of each category of the ordinal scale 0 = No Relief and 4 = Significant/Excellent
Time Frame
30 minutes
Title
Response on Dry Mouth Relief
Description
Count of each category of the ordinal scale 0 = No Relief and 4 = Significant/Excellent
Time Frame
60 minutes
Title
Response on Dry Mouth Relief
Description
Count of each category of the ordinal scale 0 = No Relief and 4 = Significant/Excellent
Time Frame
120 minutes
Title
Response on Dry Mouth Relief
Description
Count of each category of the ordinal scale 0 = No Relief and 4 = Significant/Excellent
Time Frame
240 minutes
Title
Response to Effectively Lubricates the Mouth
Description
5 point ordinal scale 1 = Poor and 5 = Excellent
Time Frame
5 minutes
Title
Response to Effectively Lubricates the Mouth
Description
5 point ordinal scale 1 = Poor and 5 = Excellent
Time Frame
15 minutes
Title
Response to Effectively Lubricates the Mouth
Description
5 point ordinal scale 1 = Poor and 5 = Excellent
Time Frame
30 minutes
Title
Response to Effectively Lubricates the Mouth
Description
5 point ordinal scale 1 = Poor and 5 = Excellent
Time Frame
60 minutes
Title
Response to Effectively Lubricates the Mouth
Description
5 point ordinal scale 1 = Poor and 5 = Excellent
Time Frame
120 minutes
Title
Response to Effectively Lubricates the Mouth
Description
5 point ordinal scale 1 = Poor and 5 = Excellent
Time Frame
240 minutes
Title
Response to Feel Comfortable in the Mouth
Description
5 point ordinal scale 1 = Poor and 5 = Excellent
Time Frame
5 minutes
Title
Response to Feel Comfortable in the Mouth
Description
5 point ordinal scale 1 = Poor and 5 = Excellent
Time Frame
15 minutes
Title
Response to Feel Comfortable in the Mouth
Description
5 point ordinal scale 1 = Poor and 5 = Excellent
Time Frame
30 minutes
Title
Response to Feel Comfortable in the Mouth
Description
5 point ordinal scale 1 = Poor and 5 = Excellent
Time Frame
60 minutes
Title
Response to Feel Comfortable in the Mouth
Description
5 point ordinal scale 1 = Poor and 5 = Excellent
Time Frame
120 minutes
Title
Response to Feel Comfortable in the Mouth
Description
5 point ordinal scale 1 = Poor and 5 = Excellent
Time Frame
240 minutes
Title
Response to Soothing in the Mouth
Description
5 point ordinal scale 1 = Poor and 5 = Excellent
Time Frame
5 minutes
Title
Response to Soothing in the Mouth
Description
5 point ordinal scale 1 = Poor and 5 = Excellent
Time Frame
15 minutes
Title
Response to Soothing in the Mouth
Description
5 point ordinal scale 1 = Poor and 5 = Excellent
Time Frame
30 minutes
Title
Response to Soothing in the Mouth
Description
5 point ordinal scale 1 = Poor and 5 = Excellent
Time Frame
60 minutes
Title
Response to Soothing in the Mouth
Description
5 point ordinal scale 1 = Poor and 5 = Excellent
Time Frame
120 minutes
Title
Response to Soothing in the Mouth
Description
5 point ordinal scale 1 = Poor and 5 = Excellent
Time Frame
240 minutes
Title
Response to Effectively Moistens the Mouth
Description
5 point ordinal scale 1 = Poor and 5 = Excellent
Time Frame
5 minutes
Title
Response to Effectively Moistens the Mouth
Description
5 point ordinal scale 1 = Poor and 5 = Excellent
Time Frame
15 minutes
Title
Response to Effectively Moistens the Mouth
Description
5 point ordinal scale 1 = Poor and 5 = Excellent
Time Frame
30 minutes
Title
Response to Effectively Moistens the Mouth
Description
5 point ordinal scale 1 = Poor and 5 = Excellent
Time Frame
60 minutes
Title
Response to Effectively Moistens the Mouth
Description
5 point ordinal scale 1 = Poor and 5 = Excellent
Time Frame
120 minutes
Title
Response to Effectively Moistens the Mouth
Description
5 point ordinal scale 1 = Poor and 5 = Excellent
Time Frame
240 minutes
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
Screening - Start of Wash-In Visit
Subject who is ≥18 years of age and complains of dry mouth
Only 1 subject per household is allowed into study
Subject with a Challacombe scale score of 1 or higher
Subject agrees to refrain from eating spicy foods and foods containing garlic beginning 48-hours prior to all study visits
Subject agrees to eat a meal prior to all study visits that include sample evaluation in the clinic
Subject agrees to not eat, drink, chew tobacco, chew gum, smoke, brush or floss teeth for 2-hours prior to sample evaluation study visits
Subject agree to not use any oral care products and any type of breath mint or lozenges for 2-hours prior to sample evaluation study visits
Subject agrees to refrain from any food and liquid during the 5-hour study visits except for what is provided by the study research staff (e.g., water and treatments A and B during evaluation periods)
Subject agrees to only use those clinical oral care supplies provided during the entire study
Able to understand and willing to sign the Informed Consent Form
Water Only Evaluation Visit
Subject has successfully completed a ≥ 2-day wash-in period
Subject has Challacombe scale score of 1 or higher
Subject has refrained from eating spicy foods and foods containing garlic beginning 48-hours prior to the sample evaluation visits
Subject ate a meal prior to sample evaluation study visits
Subject has not eaten, drank, chewed tobacco, chewed gum, smoked, brushed or flossed teeth for 2-hours prior to sample evaluation study visits
Subject has not used any oral care products, any type of breath mint or lozenges for 2-hours prior to sample evaluation study visits
Subject agrees to refrain from any food and liquid during the 5-hour study visits except for what is provided by the study research staff (e.g., water and treatments A and B during evaluation periods)
Subject has used only those clinical oral care supplies provided during study
Baseline Period 1/Randomization Visit
Subject has successfully completed a ≥ 2-day wash-in period
Subject has a Challacombe Scale score of 1 or higher
Subject has refrained from eating spicy foods and foods containing garlic beginning 48-hours prior to sample evaluation study visits
Subject ate a meal prior to sample evaluation study visits
Subject has not eaten, drank, chewed tobacco, chewed gum, smoked, brushed or flossed teeth for 2-hours prior to sample evaluation study visits
Subject has not used any oral care products and any type of breath mint or lozenges for 2-hours prior to sample evaluation study visits
Subject agrees to refrain from any food and liquid during the 5-hour study visits except for what is provided by the study research staff (e.g., water and treatments A and B during evaluation periods)
Subject has used only those clinical oral care supplies provided during study
Exclusion Criteria:
Subject Exclusion Criteria for Start of Wash-In, Water Only Evaluation and Baseline Period 1 (Randomization Visit)
Subject has active mouth sores (e.g., cold sores, cuts, burns, canker sores)
Subject has a life-threatening pathological condition
Subject is participating in another clinical trial at the time of the study
Subject has profound marginal periodontal disease (purulent exudate, tooth mobility, and/or extensive alveolar bone loss)
Medical and oral conditions that, in the investigator's judgment, may compromise the subject's safety or interfere with the conduct and outcome of the study
Difficult to be compliant with recalls, such as extensive travel commitments, lack of transportation etc.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Yiming Li, DDS,MSD,PhD
Organizational Affiliation
Loma Linda University, School of Dentistry
Official's Role
Principal Investigator
Facility Information:
Facility Name
Loma Linda University, School of Dentistry
City
Loma Linda
State/Province
California
ZIP/Postal Code
92350
Country
United States
12. IPD Sharing Statement
Plan to Share IPD
No
Citations:
PubMed Identifier
8626175
Citation
Locker D. Xerostomia in older adults: a longitudinal study. Gerodontology. 1995 Jul;12(1):18-25. doi: 10.1111/j.1741-2358.1995.tb00125.x.
Results Reference
background
PubMed Identifier
9344281
Citation
Fox PC. Management of dry mouth. Dent Clin North Am. 1997 Oct;41(4):863-75.
Results Reference
background
PubMed Identifier
11488135
Citation
Guijarro Guijarro B, Lopez Sanchez AF, Hernandez Vallejo G. Treatment of xerostomia. A review. Med Oral. 2001 Jan-Feb;6(1):7-18. English, Spanish.
Results Reference
background
PubMed Identifier
15765951
Citation
Fontana M, Zunt S, Eckert GJ, Zero D. A screening test for unstimulated salivary flow measurement. Oper Dent. 2005 Jan-Feb;30(1):3-8.
Results Reference
background
PubMed Identifier
8626174
Citation
Andersson G, Johansson G, Attstrom R, Edwardsson S, Glantz PO, Larsson K. Comparison of the effect of the linseed extract Salinum and a methyl cellulose preparation on the symptoms of dry mouth. Gerodontology. 1995 Jul;12(1):12-7. doi: 10.1111/j.1741-2358.1995.tb00124.x.
Results Reference
background
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Evaluation of the Efficacy of 3M Dry Mouth Moisturizing Spray
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