Excision of Strip of Deep Fascia to Reduce Seroma Formation and Extrusion of Tissue Expanders
Primary Purpose
Seroma
Status
Completed
Phase
Not Applicable
Locations
Egypt
Study Type
Interventional
Intervention
Excision of strip of deep fascia
Sponsored by
About this trial
This is an interventional prevention trial for Seroma focused on measuring Tissue expander, seroma, extrusion, lymphatics, deep fascia, Rate of seroma formation after excision of strip of deep fascia
Eligibility Criteria
Inclusion Criteria:
- Tissue expanders in neck and limbs.
Exclusion Criteria:
- Tissue expanders in other parts of the body.
Sites / Locations
- Cairo University
Arms of the Study
Arm 1
Arm Type
Other
Arm Label
Rate of seroma formation
Arm Description
Excision of strip of deep fascia was assessed regarding the rate of seroma formation with tissue expander insertion
Outcomes
Primary Outcome Measures
Reduction of seroma formation
Secondary Outcome Measures
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT00968318
Brief Title
Excision of Strip of Deep Fascia to Reduce Seroma Formation and Extrusion of Tissue Expanders
Official Title
Excision of Strip of Deep Fascia to Reduce Seroma Formation and Extrusion of Tissue Expanders
Study Type
Interventional
2. Study Status
Record Verification Date
August 2009
Overall Recruitment Status
Completed
Study Start Date
May 2006 (undefined)
Primary Completion Date
September 2008 (Actual)
Study Completion Date
November 2008 (Actual)
3. Sponsor/Collaborators
Name of the Sponsor
Cairo University
4. Oversight
Data Monitoring Committee
No
5. Study Description
Brief Summary
Tissue expansion has enjoyed a wide range of applications since the technique was popularized in the latter quarter of the last century. During the expansion process, subcutaneous fat liquefies, skin becomes thinner, muscles atrophy, blood inflow increases, and lymphatics get occluded. All these factors predispose to seroma formation and implant extrusion.
A similar problem occurred with lymphoedema patients, and one of the lines of treatment was creation of a connection to the deep lymphatics to facilitate absorption of accumulated fluid. The same principle is to be extrapolated to patients having tissue expanders inserted in the neck and limbs and its effect is to be noted on the incidence of seroma .
Detailed Description
The techniques of tissue expansion have been used for many years to expand normal skin adjacent to the site of a defect. Initially described by Neuman in 1953, it gained widespread popularity in the eighth decade of the last century after the work of Radovan, and has been progressively popular since.
The physiology of prolonged tissue expansion was not just a matter of stretching skin, but the actual formation of additional new skin which had all the attributes of the original tissue. Austad et al. postulated that tissue expansion caused a decrease in cell density in the basal layer of the skin and that cell density might regulate skin mitotic activity. A lower cell density resulted in a greater cell proliferation, resulting in growth of additional skin. Inflation of the tissue expander was found to cause a threefold elevation of epidermal mitotic activity within 24 hours, followed by a gradual return to normal baseline over 2 to 5 days. Conversely, deflation of the expander caused a transient decrease in epidermal mitotic activity. The increase in mitosis returned to normal 4 weeks after expansion.
The dermis and subcutaneous tissues were thinned as a result of tissue expansion leading to an overall decrease in tensile strength of the expanded skin (5-7) and this persisted 36 weeks after expansion. The subcutaneous layer of fat was intolerant to stretching causing significant thinning. With faster expansion, fat necrosis could be seen. Pressure necrosis on subcutaneous fat led to liquefaction and seroma formation. With progression of expansion compression of superficial lymphatics resulted in their occlusion and lymph accumulation. Furthermore, the muscle layer in pigs, which was similar to the platysmal layer in humans, tended to atrophy with maximal expansion. As expansion proceeded, there was an increase in the number and size of the blood vessels within flaps supplied by random-pattern vessels and, if present, axial vessels. These changes corresponded to the demonstrated increase in blood flow to expanded flaps. In the study by Saxby this lead to surviving lengths after expansion being 50 percent greater than the delayed controls, and nearly 150 percent greater than comparable flaps raised acutely.
These histologic and physiologic findings would explain the high incidence of seroma formation with tissue expanders especially those inserted in areas rich in subcutaneous fat, such as the neck and limbs. During the expansion process, subcutaneous fat liquefies, skin becomes thinner, muscles atrophy, blood inflow increases, and lymphatics get occluded. All these factors when coupled with the fact that mere presence of a foreign body incites fluid exudation would be a frank invitation for seroma formation and implant extrusion.
Reported rates of seroma varied in the literature between 5-18%. Its effect ranged from minor complications that that did not interrupt the expansion process or require any operative intervention (32%) up to major complications that required additional operative intervention (12%).
Opinions differed between authors regarding seroma prevention. Several authors omit use of drainage procedures to prevent infection. Others use closed suction drains but there was an increased risk of infection; and seromas tended to occur following their removal.
External filling ports might drain seromas through the entry port, but at the risk of increased infection rates (19). Over inflation of the expanders to obliterate any dead space came with the risk of overlying skin ischemia and necrosis.
As a projection to the hypothesis of Thompson on lymphoedema management, this study was performed to find the effect of opening new drainage channels between the superficial and deep lymphatics on the incidence of seroma formation.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Seroma
Keywords
Tissue expander, seroma, extrusion, lymphatics, deep fascia, Rate of seroma formation after excision of strip of deep fascia
7. Study Design
Primary Purpose
Prevention
Study Phase
Not Applicable
Interventional Study Model
Single Group Assignment
Masking
None (Open Label)
Allocation
N/A
Enrollment
56 (Actual)
8. Arms, Groups, and Interventions
Arm Title
Rate of seroma formation
Arm Type
Other
Arm Description
Excision of strip of deep fascia was assessed regarding the rate of seroma formation with tissue expander insertion
Intervention Type
Procedure
Intervention Name(s)
Excision of strip of deep fascia
Intervention Description
operative technique to excise deep fascia.
Primary Outcome Measure Information:
Title
Reduction of seroma formation
Time Frame
6 months
10. Eligibility
Sex
All
Minimum Age & Unit of Time
12 Years
Maximum Age & Unit of Time
55 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
Tissue expanders in neck and limbs.
Exclusion Criteria:
Tissue expanders in other parts of the body.
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Adel Wilson, MD
Organizational Affiliation
Cairo University
Official's Role
Principal Investigator
Facility Information:
Facility Name
Cairo University
City
Cairo
Country
Egypt
12. IPD Sharing Statement
Citations:
PubMed Identifier
19644263
Citation
Adler N, Dorafshar AH, Bauer BS, Hoadley S, Tournell M. Tissue expander infections in pediatric patients: management and outcomes. Plast Reconstr Surg. 2009 Aug;124(2):484-489. doi: 10.1097/PRS.0b013e3181adcf20.
Results Reference
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Excision of Strip of Deep Fascia to Reduce Seroma Formation and Extrusion of Tissue Expanders
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