Exercise and Disease Progression in Amyotrophic Lateral Sclerosis Patients
Amyotrophic Lateral Sclerosis
About this trial
This is an interventional supportive care trial for Amyotrophic Lateral Sclerosis focused on measuring Amyotrophic Lateral Sclerosis, aerobic exercise, functional outcome, non-invasive ventilation, oxygen uptake
Eligibility Criteria
Inclusion Criteria:
- Consecutive patients diagnosed with definite, probable, or probable laboratory supported ALS
- Disease duration from first symptoms between 6-24 months to exclude slow and fast progression
- ALSFRS-R ≥ 30
- FVC (%predicted) ≥ 70%
Exclusion Criteria:
- Other medical conditions, like cardiac insufficiency and lung disorders or others conditions limiting exercise training;
- Heavy smoking habits with laboratorial evidence of significant bronchial constriction;
- Signs of associated dementia or psychiatric disorders.
Note: None of the patients were on tube feeding, invasive or non-invasive mechanical ventilation at admission of study protocol (T1).
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
moderate exercise + standard care
Standard care
This group performed a moderate exercise protocol with training zone determined by Cardiopulmonary Exercise testing added to standard care program based on American Academy of Neurology guidelines.
This group performed a standard care program based on American Academy of Neurology guidelines, without exercise intensity control.