Exercise and Neutrophil Function in COPD
Chronic Obstructive Airway Disease, Neutrophil Function Disorder
About this trial
This is an interventional supportive care trial for Chronic Obstructive Airway Disease focused on measuring Neutrophil, Exercise, COPD, Pulmonary Rehabilitation
Eligibility Criteria
Inclusion Criteria:
- COPD group - 15 Participants who have been diagnosed with any severity of COPD (according to BTS criteria, i.e. >10 pack-year smoking history and post-bronchodilator spirometry FEV1/FVC ratio <0.70 and FEV<80%) and have completed at least 12 from 18 sessions of a pulmonary rehabilitation programme.
- Age 50-80 years.
- Current non-smoker.
- Control group - 15 Participants who will act as Controls, without COPD or cardiovascular disease
- Age 50-80 years (ideally of similar gender distribution)
- Current non-smoker.
- Spirometry: FEV1/FVC>0.7 and FEV>80% predicted
Exclusion Criteria:
- Known asthma or allergic rhinitis or other respiratory disease (bronchiectasis, pulmonary fibrosis).
- A change in any medications within 4 weeks or during the study.
- Require domiciliary oxygen.
- Acute exacerbation of COPD within 4 weeks of study entry.
- Any infection or illness within 4 weeks of study entry.
- Other active inflammatory conditions e.g. rheumatoid arthritis, cancer, unstable cardiac conditions.
- Receiving oral steroids or other immunomodulating drugs.
- Currently undergoing exercise training (including Pulmonary Rehabilitation).
- Any previous cardiovascular contraindications to exercise (e.g. unstable angina).
- Inability to complete the 6MWT due to physical or mental impairment.
- Exhaled CO>10ppm or smoked any cigarettes within 6 months.
- Inability or unwillingness to sign informed consent.
Sites / Locations
- Prince Philip Hospital
Arms of the Study
Arm 1
Experimental
Interval Exercise
Subjects will undertake an interval exercise session (on a harnessed treadmill) (HP Cosmos Mercury 4.0, HP Cosmos Sports and Medical Gmbh, Nussdorf-Traustein,Germany) based on the average speed calculated from the 6 minute walk test (6MWT). Intervals are based on the work previously done by Mador et al., 2009 who used intervals of 150% (for 1 minute) followed by intervals of 75% (for 2 minutes) based on 80% average speed from the 6 minute walk test. This study repeated these intervals 7 times with a duration of 23 minutes in total for the exercise intervention with the 75% intervals at the start and at the end of the exercise session. No warm up was undertaken for this method as it was a walking exercise test and the risk of injury was minimised with use of the harnessed treadmill.