Exercise in Health and Chronic Obstructive Pulmonary Disease
Chronic Obstructive Pulmonary Disease
About this trial
This is an interventional basic science trial for Chronic Obstructive Pulmonary Disease
Eligibility Criteria
Inclusion Criteria:
- Chronic Obstructive Pulmonary Disease (COPD) patients (over 18 years old) and
- age-matched healthy controls (over 18 years old)
Exclusion Criteria:
- Severe Chronic Obstructive Pulmonary Disease (volume exhaled at the end of the first section of forced expiration is predicted to be under 30 percent),
- Severe Heart Failure
Sites / Locations
- Veterans Affairs Salt Lake City Heath Care System
Arms of the Study
Arm 1
Arm 2
Experimental
Experimental
Healthy volunteers
COPD patients
Healthy volunteers will undergo one or more exercise interventions: knee-extensor exercise test; exercise test with restricting/releasing blood flow; exercise test with variable oxygen concentration and MRI; or exercise test with oral antioxidant or placebo cocktail.
Patients with Chronic Obstructive Pulmonary Disease (COPD) will undergo one or more exercise interventions: knee-extensor exercise test; exercise test with restricting/releasing blood flow; exercise test with variable oxygen concentration and MRI; or exercise test with oral antioxidant or placebo cocktail.