Exercise Training and Cognitive Function in Kidney Disease
Cognitive Function, Preclinical, Chronic Kidney Diseases, Older Adults
About this trial
This is an interventional treatment trial for Cognitive Function, Preclinical focused on measuring Cognitive function, Kidney Disease, Exercise, Older adults
Eligibility Criteria
Inclusion Criteria:
- English speaking men and women
- diagnosed stage 3-5 CKD (eGFR<60 to 15 ml/min);
- 60-80 years of age,
- self-experienced persistent decline in cognitive capacity determined as self-reported cognitive complaint (i.e., answering "yes" to the question: "Do you feel like your memory or thinking skills have gotten worse recently?" (before any clinical impairment of cognition has occurred)
- ability to undergo an MRI;
- no history of major head trauma.
Exclusion Criteria:
• current/past diagnosis of neurological/psychiatric disorders;
- any medications to improve cognition or mood;
- Diagnosed Dementia or a score of <2 on the mini-cog assessment
- Ischemic ulcerations or gangrene on the feet or legs;
- Participating in a supervised exercise program with intent to increase fitness levels 3 days/week,
- Requires assistive ambulation;
Limited exercise capacity due to conditions other than claudication
- unstable angina,
- Claudication
- severe arthritis,
- extreme dyspnea on exertion,
- unstable coronary artery disease;
- Class III-IV heart failure;
- Current uncontrolled sustained arrhythmias,
- severe/symptomatic aortic or mitral stenosis,
- hypertrophic obstructive cardiomyopathy,
- severe pulmonary hypertension,
- active myocarditis/pericarditis,
- thrombophlebitis,
- recent systemic/pulmonary embolus (within 3 months);
- Resting systolic BP >200 mmHg or resting diastolic BP >110 mmHg;
- Revascularization procedures within the previous 6 months;
- Any unforeseen illness or disability that would preclude exercise testing or training based on patient provider opinion;
- Pregnancy
- No diagnosis of CKD
One or more contraindication for MRI
- cardiac pacemaker,
- aneurysm clip,
- cochlear implants,
- shrapnel,
- history of metal fragments in eyes,
- neurostimulators,
- diagnosed claustrophobia.
Sites / Locations
- University of Illinois at Chicago
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Home-based walking exercise
Control
Home-based exercise program: The exercise training group will participate in an educational session on exercise for CKD. Participants will receive a packet of information with an exercise prescription and a heart rate monitor that monitors the exercise. Participants will be asked to exercise (a brisk walk) at home, 3 times per week, for 30-60 minutes for 24 weeks. Participants will be contacted via phone biweekly or more frequently if they are behind the exercise routine, and the investigators will meet with them monthly to provide encouragement and progression of exercise, and to download the heart rate monitor.
The control group will receive standard instructions on exercise for patients with kidney disease similar to what is commonly done in clinical practice. The control group will not receive an exercise prescription or heart rate monitor. Participants will be contacted via phone biweekly to answer any questions and ensure continued study participation. The control group will not meet with the investigators monthly.