Expectation of Unpleasant Events in Anxiety Disorders

INCLUSION CRITERIA: Inclusion criteria for both patients and healthy controls All subjects must be able to give written informed consent prior to participation in this study. PATIENTS ONLY: May have DSM-IV-TR diagnoses of an anxiety disorder (GAD; SAD; Panic disorder; specific phobia) or mood disorder (MDD; BP). PATIENTS ONLY: May be taking the mood stabilizers, Depakote or Lithium Carbonate. Speaks English fluently EXCLUSION CRITERIA: Exclusion criteria for healthy subjects Female subjects who are currently pregnant Subjects who meet DSM-IV criteria for current alcohol or substance abuse Subjects with a history of alcohol or substance dependence within 6 months prior to screening Current Axis I psychiatric disorders as identified with the Structured Clinical Interview for DSM-IV-TR axis disorders, non-patient edition (SCID-np). Past history of any psychotic disorder or bipolar disorder. I-Q<80 Medical illnesses (such as diabetes or hypertension) or neurological illnesses (such as carpal tunnel syndrome for shocks to be delivered on affected arm; organic brain impairment; seizure disorder) likely to interfere with the study. Subjects who are on a medication that may interfere with the study. Employee of NIMH or an immediate family member who is a NIMH employee. Exclusion criteria for patients Patients who would be unable to comply with study procedures or assessments; Female patients who are currently pregnant; Patients who meet DSM-IV criteria for current alcohol or substance abuse Subjects with a history of alcohol or substance dependence within 6 months prior to screening; Patients who are on a medication (other than mood stabilizers lithium carbonate or Depakote) that may interfere with the study Medical illnesses (such as diabetes or hypertension) or neurological illnesses (such as carpal tunnel syndrome; organic brain impairment; seizure disorder) likely to interfere with the study. Patients will be excluded if they have a current or past history of, delirium, dementia, amnestic disorder, any of the pervasive developmental disorders; or cognitive impairment. Current Axis I psychiatric disorders as identified with the Structured Clinical Interview for DSM-IV-TR axis disorders, non-patient edition (SCID) with the exception of the mood and anxiety disorders. Past history of any psychotic disorder or bipolar disorder.. IQ<80 Employee of NIMH or an immediate family member who is an NIMH employee. Additional exclusion criteria for the active avoidance task Color blindness