Expectation of Unpleasant Events in Anxiety Disorders
Anxiety Disorders

About this trial
This is an interventional basic science trial for Anxiety Disorders focused on measuring Anxiety Disorder, Psychophysiology, Shock Threat, Context Conditioning, Agoraphobia, Panic Disorder, Generalized Anxiety Disorder, GAD, Healthy Volunteer, HV
Eligibility Criteria
INCLUSION CRITERIA: Inclusion criteria for both patients and healthy controls All subjects must be able to give written informed consent prior to participation in this study. PATIENTS ONLY: May have DSM-IV-TR diagnoses of an anxiety disorder (GAD; SAD; Panic disorder; specific phobia) or mood disorder (MDD; BP). PATIENTS ONLY: May be taking the mood stabilizers, Depakote or Lithium Carbonate. Speaks English fluently EXCLUSION CRITERIA: Exclusion criteria for healthy subjects Female subjects who are currently pregnant Subjects who meet DSM-IV criteria for current alcohol or substance abuse Subjects with a history of alcohol or substance dependence within 6 months prior to screening Current Axis I psychiatric disorders as identified with the Structured Clinical Interview for DSM-IV-TR axis disorders, non-patient edition (SCID-np). Past history of any psychotic disorder or bipolar disorder. I-Q<80 Medical illnesses (such as diabetes or hypertension) or neurological illnesses (such as carpal tunnel syndrome for shocks to be delivered on affected arm; organic brain impairment; seizure disorder) likely to interfere with the study. Subjects who are on a medication that may interfere with the study. Employee of NIMH or an immediate family member who is a NIMH employee. Exclusion criteria for patients Patients who would be unable to comply with study procedures or assessments; Female patients who are currently pregnant; Patients who meet DSM-IV criteria for current alcohol or substance abuse Subjects with a history of alcohol or substance dependence within 6 months prior to screening; Patients who are on a medication (other than mood stabilizers lithium carbonate or Depakote) that may interfere with the study Medical illnesses (such as diabetes or hypertension) or neurological illnesses (such as carpal tunnel syndrome; organic brain impairment; seizure disorder) likely to interfere with the study. Patients will be excluded if they have a current or past history of, delirium, dementia, amnestic disorder, any of the pervasive developmental disorders; or cognitive impairment. Current Axis I psychiatric disorders as identified with the Structured Clinical Interview for DSM-IV-TR axis disorders, non-patient edition (SCID) with the exception of the mood and anxiety disorders. Past history of any psychotic disorder or bipolar disorder.. IQ<80 Employee of NIMH or an immediate family member who is an NIMH employee. Additional exclusion criteria for the active avoidance task Color blindness
Sites / Locations
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Arms of the Study
Arm 1
Experimental
Threat conditions
acoustic startle and shock device