Back to resultsExpression of IRAK1 Gene rs1059703-related Single- Nucleotide Polymorphisms in Egyptian Patient With Rheumatoid Arthritis
Primary Purpose
Rheumatoid Arthritis (RA)
Status
Recruiting
Phase
Not Applicable
Locations
Egypt
Study Type
Interventional
Intervention
PCR polymorphism
Sponsored by
About this trial
This is an interventional diagnostic trial for Rheumatoid Arthritis (RA)
Eligibility Criteria
Inclusion Criteria:
- approval to sign an informed written consent, patient diagnosed rheumatoid arthritis, patient age range 17-85 year and both sexes are included.
Exclusion Criteria:
- Refusal to sign an informed written consent and patient with other autoimmune disease.
Sites / Locations
- Sohag university hospitalRecruiting
Arms of the Study
Arm 1
Arm 2
Arm Type
Active Comparator
Active Comparator
Arm Label
Group 1
Group 2
Arm Description
Normal control
Diagnosed Rhomatoid arthritis patients
Outcomes
Primary Outcome Measures
rs1059703 PCR polymorphism in rhomatoid arthritis patients
PCR polymorphism
Secondary Outcome Measures
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT05588817
Brief Title
Expression of IRAK1 Gene rs1059703-related Single- Nucleotide Polymorphisms in Egyptian Patient With Rheumatoid Arthritis
Official Title
Expression of IRAK1 Gene rs1059703-related Single- Nucleotide Polymorphisms in Egyptian Patient With Rheumatoid Arthritis
Study Type
Interventional
2. Study Status
Record Verification Date
October 2022
Overall Recruitment Status
Recruiting
Study Start Date
December 30, 2022 (Anticipated)
Primary Completion Date
December 1, 2023 (Anticipated)
Study Completion Date
December 1, 2023 (Anticipated)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Principal Investigator
Name of the Sponsor
Sohag University
4. Oversight
Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No
5. Study Description
Brief Summary
Rheumatoid arthritis (RA) is known as a long-lasting inflammatory autoimmune disease affecting the diarthrodial joints, which is diagnosed by inflammation and hyperplasia in synovium, generation of RF and anti-citrullinated protein antibody (ACPA), deformity of cartilage and bone, systemic injuries involving cardiovascular, pulmonary, psychological, and skeletal disorders (McInnes and Schett., 2011).
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Rheumatoid Arthritis (RA)
7. Study Design
Primary Purpose
Diagnostic
Study Phase
Not Applicable
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
90 (Anticipated)
8. Arms, Groups, and Interventions
Arm Title
Group 1
Arm Type
Active Comparator
Arm Description
Normal control
Arm Title
Group 2
Arm Type
Active Comparator
Arm Description
Diagnosed Rhomatoid arthritis patients
Intervention Type
Genetic
Intervention Name(s)
PCR polymorphism
Intervention Description
PCR polymorphism in Rhomatoid arthritis patients in Egypt
Primary Outcome Measure Information:
Title
rs1059703 PCR polymorphism in rhomatoid arthritis patients
Description
PCR polymorphism
Time Frame
1 year
10. Eligibility
Sex
Female
Minimum Age & Unit of Time
17 Years
Maximum Age & Unit of Time
85 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria:
approval to sign an informed written consent, patient diagnosed rheumatoid arthritis, patient age range 17-85 year and both sexes are included.
Exclusion Criteria:
Refusal to sign an informed written consent and patient with other autoimmune disease.
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
Alaa A Abdel salam, Assistant lecturer
Phone
01099058889
Email
alaa.eisa@med.sohag.edu.eg
First Name & Middle Initial & Last Name or Official Title & Degree
Esam M Abulfadl, Professor
Facility Information:
Facility Name
Sohag university hospital
City
Sohag
Country
Egypt
Individual Site Status
Recruiting
Facility Contact:
First Name & Middle Initial & Last Name & Degree
Magdy M Amin, Professor
12. IPD Sharing Statement
Plan to Share IPD
Yes
Learn more about this trial
Expression of IRAK1 Gene rs1059703-related Single- Nucleotide Polymorphisms in Egyptian Patient With Rheumatoid Arthritis
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