Extended Access of Momelotinib in Adults With Myelofibrosis
Neoplasms, Post-polycythemia Vera Myelofibrosis (Post-PV MF), Primary Myelofibrosis (PMF)
About this trial
This is an interventional treatment trial for Neoplasms
Eligibility Criteria
Key Inclusion Criteria:
- Currently enrolled in Studies GS-US-352-0101, GS-US-352-1214, GS-US-352-1154, or SRA-MMB-301
- Able to comprehend and willing to sign the informed consent form
Key Exclusion Criteria:
- Known hypersensitivity to MMB, its metabolites, or formulation excipients
NOTE: Other protocol defined Inclusion/ Exclusion criteria may apply.
Sites / Locations
- IC Irvine Health
- GSK Investigational Site
- Stanford Hospital and Clinics
- GSK Investigational Site
- University of Colorado Cancer Center
- GSK Investigational Site
- Mayo Clinic Florida
- GSK Investigational Site
- Moffitt Cancer Center
- GSK Investigational Site
- Winship Cancer Institute, Emory University
- Northwest Oncology & Hematology - Rolling Meadows
- GSK Investigational Site
- Saint Agnes Hospital
- Dana-Farber Cancer Institute (DFCI)
- GSK Investigational Site
- GSK Investigational Site
- Mayo Clinic - Department of Hematology
- Washington University School of Medicine Siteman Cancer Center
- GSK Investigational Site
- GSK Investigational Site
- Hackensack University Medical Center
- GSK Investigational Site
- Montefiore Medical Center
- Cleveland Clinic Foundation
- GSK Investigational Site
- GSK Investigational Site
- GSK Investigational Site
- Mayo Clinic Building - Phoenix
- Icon Cancer Care Wesley
- GSK Investigational Site
- Flinders Medical Centre
- GSK Investigational Site
- GSK Investigational Site
- Frankston Hospital
- GSK Investigational Site
- The Alfred Hospital
- GSK Investigational Site
- Peter MacCallum Cancer Centre
- GSK Investigational Site
- Royal Perth Hospital
- Ordensklinikum Linz Elisabethinen
- Medizinische Universität Wien
- GSK Investigational Site
- GSK Investigational Site
- Algemeen Ziekenhuis Sint-Jan Brugge-Oostende - Campus Sint-Jan
- GSK Investigational Site
- Ziekenhuis Netwerk Antwerpen Stuivenberg
- GSK Investigational Site
- GSK Investigational Site
- Universitaire Ziekenhuis Leuven
- Centre Hospitalier Universitaire de Liège Site Sart Tilman
- GSK Investigational Site
- GSK Investigational Site
- UMHAT Dr. Georgi Stranski EAD
- GSK Investigational Site
- Multiprofile Hospital for Active Treatment Ruse
- GSK Investigational Site
- National Specialized Hospital for Active Treatment of Haematologic Diseases
- University Multiprofile Hospital for Active Treatment St. Ivan Rilski
- GSK Investigational Site
- GSK Investigational Site
- GSK Investigational Site
- GSK Investigational Site
- Research Institute of the McGill University Health Centre
- Sir Mortimer B. Davis Jewish General Hospital
- Princess Margaret Cancer Centre
- Aalborg University Hospital
- Gentofte Hospital
- GSK Investigational Site
- GSK Investigational Site
- Hopital Saint-Louis
- Centre Hospitalier Le Mans
- GSK Investigational Site
- CHRU Huriez Lille
- GSK Investigational Site
- Institut Paoli Calmettes
- GSK Investigational Site
- GSK Investigational Site
- Hôpital Haut-Lévêque
- Centre Hospitalier Lyon Sud
- GSK Investigational Site
- GSK Investigational Site
- Institut Universitaire du Cancer
- GSK Investigational Site
- GSK Investigational Site
- Universitätsklinikum Aachen
- GSK Investigational Site
- GSK Investigational Site
- GSK Investigational Site
- Universitätsklinikum Halle
- GSK Investigational Site
- GSK Investigational Site
- Universitätsklinikum Schleswig-Holstein - Campus Lübeck
- University Hospital of Cologne
- Universitätsklinikum Dresden
- Universitätsklinikum Leipzig
- Johannes Gutenberg-Universität Mainz
- Petz Aladár Egyetemi Oktató Kórház - Győr
- Szent Borbála Kórház
- Dél-pesti Centrumkórház - Országos Hematológiai és Infektológiai Intézet
- Szabolcs-Szatmár-Bereg Megyei Kórházak És Egyetemi Oktatókórház
- GSK Investigational Site
- Semmelweis Egyetem I. sz. Belgyogyaszati Klinika, Hematologia
- GSK Investigational Site
- Debreceni Egyetem Klinikai Kozpont, Belgyogyaszati Klinika, Haematologiai Tanszek
- GSK Investigational Site
- GSK Investigational Site
- GSK Investigational Site
- Somogy Megyei Kaposi Mor Oktató Kórház
- GSK Investigational Site
- GSK Investigational Site
- GSK Investigational Site
- Emek Medical Center
- Barzilai Medical Center, Hematology Institute
- GSK Investigational Site
- Carmel Medical Center
- GSK Investigational Site
- GSK Investigational Site
- Hadassh Medical Organization
- Meir Medical Center
- GSK Investigational Site
- GSK Investigational Site
- GSK Investigational Site
- GSK Investigational Site
- Azienda Ospedaliero - Universitaria Careggi
- GSK Investigational Site
- GSK Investigational Site
- GSK Investigational Site
- Azienda Socio Sanitaria Territoriale Monza - Ospedale San Gerardo
- Azienda Ospedaliera Ospedali Riuniti Marche Nord
- GSK Investigational Site
- GSK Investigational Site
- GSK Investigational Site
- Azienda Ospedaliero-Universitaria Citta della Salute e della Scienza di Torino
- Azienda Ospedaliera Ordine Mauriziano di Torino
- GSK Investigational Site
- Azienda Ospedaliero Universitaria di Bologna Policlinico Sant'Orsola-Malpighi
- Azienda Ospedaliera Universitaria San Martino
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Azienda Ospedaliera Universitaria Federico II
- GSK Investigational Site
- IRCCS Centro di Riferimento Oncologico di Basilicata
- GSK Investigational Site
- Umberto I - Policlinico di Roma
- Ospedale Policlinico Giambattista Rossi Borgo Roma
- Inje University Haeundae Paik Hospital
- Kyungpook National University Hospital
- Severance Hospital
- GSK Investigational Site
- GSK Investigational Site
- GSK Investigational Site
- GSK Investigational Site
- Samsung Medical Center
- Catholic University of Korea Seoul Saint Mary's Hospital
- GSK Investigational Site
- GSK Investigational Site
- Seoul National University Hospital
- Maastricht University Medical Centre
- GSK Investigational Site
- Szpital Wojewódzki w Opolu
- Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im. Ks. B. Markiewicza
- Uniwersyteckie Centrum Kliniczne
- GSK Investigational Site
- GSK Investigational Site
- Samodzielny Publiczny Zaklad Opieki Zdrowotnej Zespól Szpitali Miejskich
- GSK Investigational Site
- GSK Investigational Site
- GSK Investigational Site
- Samodzielny Publiczny Szpital Kliniczny nr 1 w Lub
- Szpital Uniwersytecki w Krakowie, Oddzial Kliniczny Hematologii
- GSK Investigational Site
- GSK Investigational Site
- Samodzielny Publiczny Zaklad Opieki Zdrowotnej MSWiA w Poznaniu im. Ledwika Bierkowskiego
- GSK Investigational Site
- Policlinica de Diagnostic Rapid SA
- GSK Investigational Site
- GSK Investigational Site
- Spitalul Clinic Coltea
- Institutul Clinic Fundeni
- GSK Investigational Site
- Institutul Oncologic Prof. Dr. Ion Chiricuţă
- GSK Investigational Site
- Spitalul Clinic Municipal Filantropia Craiova
- GSK Investigational Site
- Institutul Regional De Oncologie IASI
- GSK Investigational Site
- Singapore General Hospital
- GSK Investigational Site
- Raffles Hospital
- Hospital Germans Trias i Pujol
- GSK Investigational Site
- Institut Hospital del Mar d'Investigacions Mèdiques
- GSK Investigational Site
- GSK Investigational Site
- Hospital Universitari Vall d'Hebron
- GSK Investigational Site
- Hospital Universitario Ramón y Cajal
- GSK Investigational Site
- Hospital Universitario 12 de Octubre
- Hospital Universitario Puerta de Hierro Majadahonda
- GSK Investigational Site
- Clínica Universidad de Navarra
- GSK Investigational Site
- GSK Investigational Site
- Hospital de Día Quirónsalud Zaragoza
- GSK Investigational Site
- Kaohsiung Medical University Chung-Ho Memorial Hospital
- GSK Investigational Site
- Kaohsiung Chang Gung Memorial Hospital
- GSK Investigational Site
- National Taiwan University Hospital
- Chang Gung Memorial Hospital - Linkou Branch
- GSK Investigational Site
- University Hospitals Bristol and Weston NHS Foundation Trust
- GSK Investigational Site
- NHS Lanarkshire
- GSK Investigational Site
- GSK Investigational Site
- University Hospital of Wales
- GSK Investigational Site
- Imperial College Healthcare NHS Trust
- GSK Investigational Site
- Oxford University Hospitals NHS Trust
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Other
Other
Other
Other
Cohort 1: Study GS-US-352-0101
Cohort 2: Study GS-US-352-1214
Cohort 3: Study GS-US-352-1154
Cohort 4: Study SRA-MMB-301
Participants will continue to receive the same dosage regimen as in the previous MMB study GS-US-352-0101 until MMB receives regulatory approval and is commercially available, or development of the product ceases.
Participants will continue to receive the same dosage regimen as in the previous MMB study GS-US-352-1214 until MMB receives regulatory approval and is commercially available, or development of the product ceases.
Participants will continue to receive the same dosage regimen as in the previous MMB study GS-US-352-1154 until MMB receives regulatory approval and is commercially available, or development of the product ceases..
Participants will continue to receive the same dosage regimen as in the previous MMB study SRA-MMB-301 until MMB receives regulatory approval and is commercially available, or development of the product ceases.