Fatigue and Skeletal Muscle Impact in Severe Axial Spondylarthritis (Famuspa)
Spondylarthritis, Fatigue, Exercise Capacity
About this trial
This is an interventional other trial for Spondylarthritis focused on measuring Axial spondylarthritis, tired, Anti-TNF alpha, exercises capacity, sacoprnia
Eligibility Criteria
Inclusion criteria:
-- Axial SA according to the ASAS criteria;
- Indication to start a biotherapy;
- ≥ 18 years old, no upper age limit;
- Subject affiliated to a social health insurance reimbursement;
- Subject having signed a dated and informed consent;
- Woman in childbearing age: negative beta-HCG test and effective contraception;
- Sufficient understanding of French to follow the protocol.
Exclusion criteria:
- Biologic treatments (ongoing or or taken during the 6 months preceding the study),
- Associated extramuscular inflammatory disease (s) (excluding ocular and cutaneous involvement) eg chronic inflammatory bowel disease
- Contraindication to the use of a biologic
- Associated fibromyalgia (Questionnaire score FiRST ≥5) achieved during the V0 visit
- History of coronary artery disease: exercise angina, acute coronary syndrome and / or coronary angioplasty,
- History of lower extremity arterial disease: vascular claudication and / or lower extremity angioplasty
- COPD
- Neuromuscular pathology
- Insufficiency of organ (renal, hepatic pulmonary heart)
- Sleep apnea
- Impossibility of giving the subject informed information (subject in emergency situation, difficulties in understanding the subject, etc.)
- Subject under the protection of justice
- Subject under guardianship or curatorship
- Breastfeeding
- Pregnancy
- Subject in exclusion period defined by another clinical study or participating in a study likely to impact the results of the research
- Corticosteroids in the 15
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Other
Other
anti-TNFα treatment and severe fatigue (FSS)
anti-TNFα treatment and with mild fatigue (FSS <4)
See bellow (section "Interventions") the full description for Measurement of aerobic exercise on cycloergometer Measurement of muscle mass by two-photon absorptiometry: specific study Measurement of Isometric Muscle Strength Blood sampling for measurement of cytokine levels in the blood Measurement of sedentarity Psychological impact Fatigue mesurement Needle muscle of the vastus lateralis (This act will be limited to patients in care at Strasbourg University Hospital n=30)
See bellow (section "Interventions") the full description for Measurement of aerobic exercise on cycloergometer Measurement of muscle mass by two-photon absorptiometry: specific study Measurement of Isometric Muscle Strength Blood sampling for measurement of cytokine levels in the blood Measurement of sedentarity Psychological impact Fatigue measurement Needle muscle of the vastus lateralis (This act will be limited to patients in care at Strasbourg University Hospital n=30)